Abstract:
:The stabilization of human immunoglobulin (IgG) by chemically modified gelatins (Haemaccel and Gelofusine) was investigated. The gelatins prevented IgG from aggregation induced by exposure to interfaces and lyophilization. The stabilization effects of the gelatins were significantly larger than those of amino acids or sugars. These investigations led to the large-scale production of an immunoglobulin preparation for intravenous use in the clinic. The clinical product meets the Japanese minimum requirements for immunoglobulin preparations for intravenous use, and the long-term preservation of this new freeze-dried preparation has demonstrated its stability.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Tomono T,Ikeda K,Suzuki Tdoi
10.1111/j.1423-0410.1986.tb00219.xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
81-6issue
2eissn
0042-9007issn
1423-0410journal_volume
51pub_type
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