Opsonic and complement-dependent bactericidal activities of various immunoglobulin preparations for intravenous use.

Abstract:

:Some effector functions of various immunoglobulin (IgG) preparations have been compared. Tests for opsonic activity were performed in vitro with human peripheral blood leukocytes and in vivo with mice. The augmentation effects on luminol-dependent chemiluminescence were investigated with human leukocytes. The complement-dependent bactericidal activities were tested with Escherichia coli. Five IgG preparations: pH 4-treated preparation (IG-100), polyethyleneglycol-treated preparation (PEG-G), sulfonated preparation (S-G), pepsin-treated preparation (Pep-G) and a preparation for intramuscular use (GGN) were studied. The results were as follows: (1) IG-100 and PEG-G exhibited strong activities in all test systems; (2) GGN showed a strong opsonic activity; (3) S-G showed relatively weak activities in all test systems, but the revertant S-G preparation exhibited somewhat stronger activities in all systems, and (4) Pep-G showed weak or no activity in all systems. These results suggest that the IgG molecules in IG-100 and PEG-G preparations have satisfactory effector functions. On the other hand, IgG molecules in S-G and Pep-G preparation may have significant deficiencies in their biological functions.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Yasuda H,Yajima T,Tanii T,Ashiba T,Iwata M

doi

10.1111/j.1423-0410.1986.tb01968.x

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

270-7

issue

4

eissn

0042-9007

issn

1423-0410

journal_volume

51

pub_type

杂志文章
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  • HLA-DR: serology versus restriction fragment length polymorphism.

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1991.tb00928.x

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  • Selective depression of blood group antigens associated with hereditary ovalocytosis among melanesians.

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    doi:10.1111/j.1423-0410.1977.tb00612.x

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  • A multi-centre study on the performance of the molecular genotyping platform ID RHD XT for resolving serological weak RhD phenotype in routine clinical practice.

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    pub_type: 杂志文章,多中心研究

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  • Transfusion history, T cell subsets and natural killer cytotoxicity in patients with colorectal cancer.

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1989.tb04954.x

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  • Separable anti-T and anti-Tk lectins from the seeds of Vicia hyrcanica.

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1988.tb03909.x

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    pub_type: 杂志文章

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    doi:10.1111/j.1423-0410.1977.tb04469.x

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    doi:10.1111/j.1423-0410.1980.tb02367.x

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  • Red-blood-cell alloimmunization and female sex predict the presence of HLA antibodies in patients undergoing liver transplant.

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    doi:10.1111/j.1423-0410.2010.01347.x

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  • Maternal-fetal hemorrhage: a reappraisal.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1996.7120103.x

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  • A comparative study of platelets stored in polyvinyl chloride containers plasticised with butyryl trihexyl citrate or triethylhexyl trimellitate.

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  • Removal of hepatitis B virus infectivity from human gamma-globulin prepared by ion-exchange chromatography.

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb01130.x

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  • 'One step closer': Acceptability of a programme of plasma donation for fractionation from men who have sex with men.

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  • Autoimmune haemolytic anaemia due to anti-phospholipid antibodies.

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1991.tb00945.x

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  • Rosette formation by sensitized human red cells- effects of source of peripheral leukocyte monolayers.

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1977.tb02245.x

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  • Donor selection in Japan: a trial of new criteria with predonation haemoglobin testing.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb04137.x

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  • Epitope specificity and inactivation mechanisms of factor VIII inhibitor antibodies.

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1992.tb01194.x

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  • Riboflavin and amotosalen photochemical treatments of platelet concentrates reduce thrombus formation kinetics in vitro.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb00046.x

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