Transfusion history, T cell subsets and natural killer cytotoxicity in patients with colorectal cancer.

Abstract:

:Blood transfusions are associated with clinical phenomena which are attributable to immune suppression. Since suppression of immune function is associated with a high risk of spontaneous malignancies, we studied T cell subsets and natural killer (NK) cytotoxicity in colorectal cancer patients and correlated the results with patients' transfusion histories. Twelve percent (14) of the 115 patients had been transfused an average of 19 years previously. Recipients of blood transfusions had low levels of peripheral lymphocytes (p = 0.191), T cells (p = 0.015), helper cells (p = 0.016) and suppressor cells (p = 0.2651) compared to previously untransfused patients. NK cytotoxicity was also significantly reduced in transfusion recipients although NK cell numbers were comparable in both groups. These results support previous studies indicating that blood transfusions cause lifelong immune modulation in the recipient. Since blood transfusions have numerous beneficial effects and immune modulation is often beneficial, longitudinal studies are necessary to define the lifetime risks and benefits.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Tartter PI,Steinberg B,Barron DM,Martinelli G

doi

10.1111/j.1423-0410.1989.tb04954.x

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

80-4

issue

2

eissn

0042-9007

issn

1423-0410

journal_volume

56

pub_type

杂志文章
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  • Mouse monoclonal anti-HBs and its use in the screening of donated blood by Elisa.

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