Abstract:
:The mechanism of CD4+ lymphocyte depletion, which is the main immunological feature in HIV-infected patients, is unclear. We investigated whether gp120-immunoglobulin-complement complexes on the surface of CD4+ cells might be involved in the elimination of CD4+ lymphocytes. The results obtained in 63 HIV-infected patients show that gp120 is attached to a variable degree to CD4+ cells. Importantly, the percentage of CD4+gp120+ lymphocytes is inversely associated with CD4+ lymphocyte counts in the peripheral blood (p = 0.0004). CD4+gp120+ blood lymphocytes bind IgM (p = 0.0027) and IgG antibodies (p = 0.0001) and complement (p = 0.0005). These results suggest that immune complex-mediated cell elimination is an important mechanism of CD4+ cell depletion in patients with AIDS.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Daniel V,Süsal C,Prodeus AP,Weimer R,Zimmermann R,Huth-Kühne A,Opelz Gdoi
10.1111/j.1423-0410.1993.tb02511.xsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
31-6issue
1eissn
0042-9007issn
1423-0410journal_volume
64pub_type
杂志文章相关文献
VOX SANGUINIS文献大全abstract::Prothrombin complex concentrates prepared for clinical use are reviewed with emphasis on frequently observed adverse reactions such as viral hepatitis and thromboembolic complications. Preparation procedures and quality control are described briefly, and the use of these concentrates in the treatment of hemophilia A p...
journal_title:Vox sanguinis
pub_type: 杂志文章,评审
doi:10.1111/j.1423-0410.1981.tb01048.x
更新日期:1981-11-01 00:00:00
abstract::IgG subclasses differ not only in their biochemical and biologic properties, but also in their occurrence as selective deficiencies, alone and in combination. The normal range of IgG subclass concentrations in children and adults is compared with deficiencies found in individuals with repeated respiratory tract infect...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1986.tb02008.x
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Variant RHD genes associated with the weak D phenotype can result in complete or partial D-epitope expression on the red cell. This study examines the genetic classification in Australian blood donors with a weak D phenotype and correlates RHD variants associated with the weak D phenotype agai...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12488
更新日期:2017-04-01 00:00:00
abstract::Idiopathic analbuminemia was fortuitously detected in a 30-year-old Italian woman. No associated disease condition could be revealed in this patient, the only consistent finding being a slight tendency to develop ankle edema. Asthenia and a moderate hypotension were also recorded. Trace amounts (5.2 mg/100 ml) of seru...
journal_title:Vox sanguinis
pub_type: 杂志文章,评审
doi:10.1111/j.1423-0410.1980.tb01851.x
更新日期:1980-09-01 00:00:00
abstract::Separable anti-T and anti-Tk lectins can be extracted from the seeds of Vicia hyrcanica. The anti-T lectin is similar to that of the peanut, Arachis hypogaea; the anti-Tk lectin compares favourably with that of Griffonia simplicifolia II. ...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1988.tb03909.x
更新日期:1988-01-01 00:00:00
abstract::The following substances were tested for their influence on granulocyte function: 8 sera that contained human granulocyte-specific alloantibodies against the antigens NA1, NA2 and NB1, two HLA antisera, and the monoclonal antibodies W6/32 and CLB-FcR-gran 1. The effects examined included spontaneous and directed migra...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1993.tb03059.x
更新日期:1993-01-01 00:00:00
abstract::We here report 2 patients who have acquired two consecutive episodes each of acute hepatitis, within 6 months after blood transfusion. The clinical and biochemical course was typical of recurrent acute viral hepatitis, and the patients recovered completely after each episode. The first infection was probably caused by...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1980.tb01859.x
更新日期:1980-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Repeated isometric muscle tension (applied tension) during blood donation reduces vasovagal symptoms in many donors. Experiencing vasovagal symptoms has been found to reduce blood donor return. However, does practicing applied tension improve blood donor return? Follow-up results from a random...
journal_title:Vox sanguinis
pub_type: 杂志文章,随机对照试验
doi:10.1111/vox.12055
更新日期:2013-11-01 00:00:00
abstract::A family is reported in which the parents' mating is of the 'double back-cross' type with respect to the Sw, Lu and Se genes. The inheritance of these genes in the children shows, with reference to a possible linkage between Sw and the two other loci, four non-recombinants and three recombinants (or vice versa). The i...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1976.tb02221.x
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:New CD36 mutations are constantly being identified, although no study has specifically targeted a Taiwanese population. CD36 deficiency can result in dyslipid state and slow clearance of chylomicron. This could be linked to more frequent lipemic donations. STUDY DESIGN AND METHODS:We used flow cytometric me...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12356
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Cold-stored platelets may be an alternative to conventional room temperature (RT) storage. However, cold-stored platelets are cleared more rapidly from circulation, reducing their suitability for prophylactic transfusion. To minimise wastage, it may be beneficial to store platelets conventiona...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12649
更新日期:2018-04-06 00:00:00
abstract::The factors that impact upon successful bone marrow transplantation leading to immunologic reconstitution in severe combined immune deficiency (SCID). Wiskott-Aldrich syndrome, and in other lethal congenital immunodeficiencies are reviewed. Evidence is presented that graft-versus-host disease (GVHD) can be abrogated b...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1986.tb02013.x
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We compared three methods of isolating platelet-rich plasma (PRP) using the Haemonetics Cell Saver 5 and one method of isolating PRP by plateletpheresis using the Haemonetics MCS+. PRP contains both platelets and fibrinogen, which are used in the preparation of haemostatic agents. MATERIALS A...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1046/j.1423-0410.2001.00099.x
更新日期:2001-10-01 00:00:00
abstract::An attempt was made to confirm a previously reported association between HLA type B16 and resistance to infection with live attenuated influenza A virus vaccine. No differences were found either in the ability of influenza virus to attach to fractionated white blood cells from HLB B16 subjects compared to cells from s...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1979.tb02292.x
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:The risk of transmitting hepatitis C (HCV) by transfusion of anti-HCV-negative screened blood was estimated for the blood donor population of Baden-Württemberg (southwestern Germany). METHODS:The data from the blood donors screened for anti-HCV and for HBsAg during 1990-1995 were analyzed. RESULTS:The preva...
journal_title:Vox sanguinis
pub_type: 杂志文章,多中心研究
doi:
更新日期:1998-01-01 00:00:00
abstract::We have studied the IgE content of different lots of commercial intravenous IgG preparations used in our day hospital as replacement therapy for patients with agammaglobulinemia. Two enzymatic methods were used: Phadezym and FAST. The average amounts of IgE detected in Endobulin and Sandoglobulin lots were very high w...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1986.tb00220.x
更新日期:1986-01-01 00:00:00
abstract::Employing standardized IgG-coated 51Cr-labelled human red blood cells (RBC), variation in rosette formation among monolayers obtained from 10 healthy donors was defined, as well as variation among 24 sequential monolayers obtained from one healthy donor and 8 sequential monolayers from a second healthy donor over a 4-...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1977.tb02245.x
更新日期:1977-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Staphylococcus epidermidis is a predominant contaminant of platelet concentrates (PCs), outcompeting other skin flora bacteria such as Staphylococcus capitis. The accumulation-associated protein (Aap), encoded by the aap gene, is involved in formation of bacterial aggregates (biofilms) in S. e...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12729
更新日期:2019-01-01 00:00:00
abstract::Hepatitis E is considered an emerging disease that may be a threat in both developing and industrialized countries all over the world. The risk of chronic hepatitis E virus infection is higher among immunocompromised patients. This study aimed to assess the status of hepatitis E infection in patients with transfusion-...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12572
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:Reconstitution of hematopoiesis by means of peripheral blood stem cells is a valid alternative to autologous bone marrow transplantation. The aim of this investigation was to increase the efficiency of collection of circulating blood progenitor cells and to obtain a purer product for transplant. METHODS:We ...
journal_title:Vox sanguinis
pub_type: 临床试验,杂志文章
doi:10.1046/j.1423-0410.1997.7340230.x
更新日期:1997-01-01 00:00:00
abstract::Serum IgE was determined by radioimmunoassay in 28 subjects affected by homozygous beta thalassemia (14 males and 14 females, aged 3-19 years, mean age 7 +/- 5.6 years). They were given transfusions with packed red cells and chelant therapy. Blood samples were taken just before a transfusion (basal value) and at 10-da...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1983.tb01931.x
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Intraoperative autologous blood recovery during radical retro pubic prostatectomy has the potential of contamination with tumour cells. Its safety is proved by similar survival rates between allogeneic and autologous transfusion to oncology patients without standardization. Silencing of the gen...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.2008.01109.x
更新日期:2008-11-01 00:00:00
abstract::Low-dose immune tolerance protocols use doses of factor VIII of less than 50 IU/kg/day to induce immune tolerance. Such protocols are chosen for a variety of reasons including cost, patient acceptability and ease of administration. Early published reports of low-dose protocols appeared in 1981, described small numbers...
journal_title:Vox sanguinis
pub_type: 杂志文章,评审
doi:10.1159/000056718
更新日期:1999-01-01 00:00:00
abstract::The successful cloning of a non-structural antigen from the genome of what is now designated as the 'hepatitis C virus' (HCV) has transformed an erstwhile diagnosis of exclusion for non-A, non-B hepatitis (NANBH). The assay has been validated against panels of known infectivity for NANBH and sera from haemophiliac pat...
journal_title:Vox sanguinis
pub_type: 杂志文章,评审
doi:10.1111/j.1423-0410.1991.tb00863.x
更新日期:1991-01-01 00:00:00
abstract::To maximize the availability of platelet concentrates (PC) and minimize their outdate, competing criteria, a computer simulation model of platelet production and distribution was developed. Based on 2 years of actual platelet orders placed with a regional blood center, the simulation program generated daily platelet o...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1983.tb04100.x
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:French Polynesia, where dengue virus (DENV) has been present for a long time, experienced two successive outbreaks of Zika (ZIKV) and chikungunya viruses (CHIKV) between 2013 and 2015. To avoid the transmission of these viruses by transfusion, nucleic acid testing (NAT) has been in place for D...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12855
更新日期:2020-02-01 00:00:00
abstract::This report describes the sensitisation of latex particles and the use of this reagent on the Autotape system to select blood donations containing greater than or equal to 4 IU/ml of tetanus toxoid antibody. Plasma containing tetanus toxoid antibodies is processed to provide immunoglobulin for passive protection again...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1978.tb02474.x
更新日期:1978-01-01 00:00:00
abstract::Recent investigation of transcriptional regulation of the ABO genes has identified a candidate erythroid cell-specific regulatory element, named the +5·8-kb site, in the first intron of ABO. Six haplotypes of the site have been reported previously. The present genetic population study demonstrated that each haplotype ...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12312
更新日期:2016-01-01 00:00:00
abstract::With regard to hemostasis and thrombosis, collagens are among the most important physiologic components of the extracellular matrix in their role as platelet activators. Differences in the rate of platelet activation markedly influence normal hemostasis and the pathological outcome of thrombosis. Thus, collagen recept...
journal_title:Vox sanguinis
pub_type: 杂志文章,评审
doi:10.1111/j.1423-0410.2002.tb05274.x
更新日期:2002-08-01 00:00:00
abstract::Two preparations of fresh frozen plasma were studied. The plasma from CPDA-1 whole blood units was either frozen within 6 h (FFP-I) or 18-20 h (FFP-II) of phlebotomy. Average activity for factor VIII for FFP-I (n = 6) and FFP-II (n = 19) was 102% and 55%, respectively (p less than 0.01). Average activity for factor V ...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1984.tb00046.x
更新日期:1984-01-01 00:00:00