CD4+ lymphocyte depletion in HIV-infected patients is associated with gp120-immunoglobulin-complement attachment to CD4+ cells.

Abstract:

:The mechanism of CD4+ lymphocyte depletion, which is the main immunological feature in HIV-infected patients, is unclear. We investigated whether gp120-immunoglobulin-complement complexes on the surface of CD4+ cells might be involved in the elimination of CD4+ lymphocytes. The results obtained in 63 HIV-infected patients show that gp120 is attached to a variable degree to CD4+ cells. Importantly, the percentage of CD4+gp120+ lymphocytes is inversely associated with CD4+ lymphocyte counts in the peripheral blood (p = 0.0004). CD4+gp120+ blood lymphocytes bind IgM (p = 0.0027) and IgG antibodies (p = 0.0001) and complement (p = 0.0005). These results suggest that immune complex-mediated cell elimination is an important mechanism of CD4+ cell depletion in patients with AIDS.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Daniel V,Süsal C,Prodeus AP,Weimer R,Zimmermann R,Huth-Kühne A,Opelz G

doi

10.1111/j.1423-0410.1993.tb02511.x

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

31-6

issue

1

eissn

0042-9007

issn

1423-0410

journal_volume

64

pub_type

杂志文章
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