Serum IgE in polytransfused thalassemic patients.

Abstract:

:Serum IgE was determined by radioimmunoassay in 28 subjects affected by homozygous beta thalassemia (14 males and 14 females, aged 3-19 years, mean age 7 +/- 5.6 years). They were given transfusions with packed red cells and chelant therapy. Blood samples were taken just before a transfusion (basal value) and at 10-day intervals (2-3 times) between transfusions. Serum IgE values were significantly increased in the thalassemic patients as compared with the control group. There was no relation between IgE and age, sex, skin allergy, familial atopy and splenectomy. Serum IgE was significantly higher in 7 subjects with a history of febrile non-hemolytic transfusion reactions. In the intertransfusional period there was a further serum IgE increase, which was statistically significant only in the older patients.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

La Rosa M,Pavone L,Musumeci S,Mollica F,Ronchetti R

doi

10.1111/j.1423-0410.1983.tb01931.x

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

384-8

issue

5

eissn

0042-9007

issn

1423-0410

journal_volume

45

pub_type

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