Abstract:
:Utilizing a kinetic enzyme-linked antiglobulin binding assay, eight examples of anti-Lea were detected in individuals whose Lewis phenotype is Le(a-b+). These antibodies were not detectable by routine hemagglutination techniques, but were indistinguishable from anti-Lea made by Le(a-b-) individuals in terms of their immunologic fine specificity. However, unlike most anti-Lea antibodies from Le(a-b-) individuals, none of the anti-Lea antibodies had an IgG component. Anti-Lea antibodies in Le(a-b+) individuals may represent immune responses on the continuum between autoimmunity and alloimmunity.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Cowles JW,Spitalnik SL,Blumberg Ndoi
10.1111/j.1423-0410.1986.tb04871.xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
164-8issue
3eissn
0042-9007issn
1423-0410journal_volume
50pub_type
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