Detection of anti-Lea in Le(a-b+) individuals by kinetic ELISA.

Abstract:

:Utilizing a kinetic enzyme-linked antiglobulin binding assay, eight examples of anti-Lea were detected in individuals whose Lewis phenotype is Le(a-b+). These antibodies were not detectable by routine hemagglutination techniques, but were indistinguishable from anti-Lea made by Le(a-b-) individuals in terms of their immunologic fine specificity. However, unlike most anti-Lea antibodies from Le(a-b-) individuals, none of the anti-Lea antibodies had an IgG component. Anti-Lea antibodies in Le(a-b+) individuals may represent immune responses on the continuum between autoimmunity and alloimmunity.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Cowles JW,Spitalnik SL,Blumberg N

doi

10.1111/j.1423-0410.1986.tb04871.x

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

164-8

issue

3

eissn

0042-9007

issn

1423-0410

journal_volume

50

pub_type

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