ABO alleles are linked with haplotypes of an erythroid cell-specific regulatory element in intron 1 with a few exceptions attributable to genetic recombination.

Abstract:

:Recent investigation of transcriptional regulation of the ABO genes has identified a candidate erythroid cell-specific regulatory element, named the +5·8-kb site, in the first intron of ABO. Six haplotypes of the site have been reported previously. The present genetic population study demonstrated that each haplotype was mostly linked with specific ABO alleles with a few exceptions, possibly as a result of hybrid formation between common ABO alleles. Thus, investigation of these haplotypes could provide a clue to further elucidation of ABO alleles.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Nakajima T,Sano R,Takahashi Y,Watanabe K,Kubo R,Kobayashi M,Takahashi K,Takeshita H,Kominato Y

doi

10.1111/vox.12312

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

90-2

issue

1

eissn

0042-9007

issn

1423-0410

journal_volume

110

pub_type

杂志文章
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