Abstract:
:Recent investigation of transcriptional regulation of the ABO genes has identified a candidate erythroid cell-specific regulatory element, named the +5·8-kb site, in the first intron of ABO. Six haplotypes of the site have been reported previously. The present genetic population study demonstrated that each haplotype was mostly linked with specific ABO alleles with a few exceptions, possibly as a result of hybrid formation between common ABO alleles. Thus, investigation of these haplotypes could provide a clue to further elucidation of ABO alleles.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Nakajima T,Sano R,Takahashi Y,Watanabe K,Kubo R,Kobayashi M,Takahashi K,Takeshita H,Kominato Ydoi
10.1111/vox.12312subject
Has Abstractpub_date
2016-01-01 00:00:00pages
90-2issue
1eissn
0042-9007issn
1423-0410journal_volume
110pub_type
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