The role of HIV infectivity and composition of factor VIII concentrates on the immunity of haemophiliacs positive for HIV antibodies.

Abstract:

:Forty-six subjects (44 HIV antibody-positive) with some degree of immune deficiency (at least TH/TS ratio below 1) were randomly distributed into 4 treatment groups. Each group was assigned to 1 of 4 products to be used exclusively for a 1-year period: 1 concentrate was of intermediate purity and not heat-treated, and 3 were heat-treated in order to inactivate HIV, 2 of them being of higher purity. At 4-6-month intervals, check-ups, including as markers clinical examination, platelet, lymphocyte and T cell subset counts, IgG levels and delayed hypersensitivity test, were carried out. At entry as well as at the end of the study, groups were not statistically distinguishable. No intra- nor inter-group differences were demonstrable for any of the markers. In contrast, using a scoring system for each marker and the results of check-up at entry as reference, significant differences between groups appeared on subsequent check-ups. Patients receiving intermediate-purity factor VIII, whether heat-treated or not, were mostly steady, while groups receiving heat-treated concentrates of a higher purity significantly worsened. This surprising outcome was no related to differences in anti-HIV titers or specificities. From this study, the potential long-term predictive value of this scoring system could not be established.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Allain JP,Frommel D,Bosser C,Gazengel C,Larrieu MJ,Sultan Y

doi

10.1111/j.1423-0410.1987.tb04911.x

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

37-43

issue

1

eissn

0042-9007

issn

1423-0410

journal_volume

53

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::A Du variant negro woman developed, during pregnancy, an anti-D that was unusual in that it bound complement. The Rh groups of the propositus and other members of her family were also unusual. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1978.tb02878.x

    authors: Ayland J,Horton MA,Tippett P,Waters AH

    更新日期:1978-01-01 00:00:00

  • Patient-specific transfusion-related acute lung injury.

    abstract::Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusion-associated mortality. The inadvertent transfusion of neutrophil antibodies can cause pulmonary transfusion reactions and TRALI. However, not all patients transfused with neutrophil antibodies experience transfusion reactions. A 2...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2007.00982.x

    authors: Muniz M,Sheldon S,Schuller RM,Young NS,Klein HG,Leitman SF,Stroncek DF

    更新日期:2008-01-01 00:00:00

  • Analbuminemia: report of a case and review of the literature.

    abstract::Idiopathic analbuminemia was fortuitously detected in a 30-year-old Italian woman. No associated disease condition could be revealed in this patient, the only consistent finding being a slight tendency to develop ankle edema. Asthenia and a moderate hypotension were also recorded. Trace amounts (5.2 mg/100 ml) of seru...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1980.tb01851.x

    authors: Dammacco F,Miglietta A,D'Addabbo A,Fratello A,Moschetta R,Bonomo L

    更新日期:1980-09-01 00:00:00

  • Flow cytometry immunophenotyping and polymerase chain reaction-site-specific primers genotyping for HPA-1 alloantigens in an Italian blood donor population.

    abstract:BACKGROUND AND OBJECTIVES:There is increasing interest in the development of rapid and reliable techniques for human platelet alloantigen (HPA) typing. This study investigates the reliability of flow cytometry for large-scale immunophenotyping of platelet alloantigens. MATERIALS AND METHODS:We used flow cytometry and ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: Tazzari PL,Cirillo D,Bontadini A,Ricci F,Masi R,Conte R

    更新日期:1998-01-01 00:00:00

  • Application of the OCR-B symbol in the data-processing system of the Finnish Red Cross Blood Transfusion Service.

    abstract::We have used the Optical Character Recognition system B (OCR-B) for automatic identification of blood samples on the Groupamatic 360 and in connection with computerized donor file management and control of blood product processing. For the Groupamatic system a device was constructed that lifts that samples, and during...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: Haahti E,Leikola J,Ruikka S

    更新日期:1981-03-01 00:00:00

  • Biofilm-associated accumulation-associated protein (Aap): A contributing factor to the predominant growth of Staphylococcus epidermidis in platelet concentrates.

    abstract:BACKGROUND AND OBJECTIVES:Staphylococcus epidermidis is a predominant contaminant of platelet concentrates (PCs), outcompeting other skin flora bacteria such as Staphylococcus capitis. The accumulation-associated protein (Aap), encoded by the aap gene, is involved in formation of bacterial aggregates (biofilms) in S. e...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12729

    authors: Alabdullatif M,Ramirez-Arcos S

    更新日期:2019-01-01 00:00:00

  • Evaluation of the de-selection of men who have had sex with men from blood donation in England.

    abstract:BACKGROUND AND OBJECTIVES:The Blood Services of the UK permanently de-select men who have had sex with men (MSM) from donating blood. The rationale for this has been questioned. This article attempts to evaluate whether this selection criterion does contribute to blood safety. MATERIALS AND METHODS:Data about transfus...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2003.00295.x

    authors: Soldan K,Sinka K

    更新日期:2003-05-01 00:00:00

  • Peroxidative events in stored platelet concentrates.

    abstract::Changes in metabolic and functional activity of platelets stored as platelet concentrates in plastic bags highly permeable to gases were investigated. The following parameters were measured daily: pH, pO2, pCO2, HCO3, glucose, lactic acid, lactic dehydrogenase, cellular ATP and platelet aggregation induced by differen...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1989.tb03043.x

    authors: Fagiolo E,Lippa S,Mores N,Oradei A,Aureli V

    更新日期:1989-01-01 00:00:00

  • The nature of human blood group A3 erythrocytes.

    abstract::A population of human erythrocytes (free A3 cells) which was entirely unagglutinable with anti-A hemagglutinins was successfully separated from human blood group A3 erythrocytes by affinity chromatography on a column of lima bean anti-A hemagglutinin (LBH)-Sepharose. The hemagglutinating and the binding properties of ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1978.tb02877.x

    authors: Oguchi Y,Kawaguchi T,Suzuta T,Osawa T

    更新日期:1978-01-01 00:00:00

  • Re-evaluating the residual risk of transfusion-transmitted Ross River virus infection.

    abstract:BACKGROUND AND OBJECTIVES:Ross River virus (RRV) is an enveloped, RNA alphavirus in the same antigenic group as chikungunya virus. Australia records an annual average of 5000 laboratory-confirmed RRV infections. While RRV is currently geographically restricted to the Western Pacific, the capacity of arboviruses for rap...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12372

    authors: Seed CR,Hoad VC,Faddy HM,Kiely P,Keller AJ,Pink J

    更新日期:2016-05-01 00:00:00

  • Leukocyte-poor platelet concentrates at the bedside by filtration through Sepacell-PL.

    abstract::We developed a new filter, 'Sepacell-PL', consisting of a blood administration set for the preparation of leukocyte-poor platelet concentrates at the patient's bedside. This filter is packed with 1.8 microns polyester fibers coated with a new polymer, and has a volume of 14 ml. Sepacell-PL removed more than 99% of the...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1989.tb00815.x

    authors: Miyamoto M,Sasakawa S,Ishikawa Y,Ogawa A,Nishimura T,Kuroda T

    更新日期:1989-01-01 00:00:00

  • Partial separation of blood clotting factors, albumin, and IgG by continuous free film electrophoresis.

    abstract::Blood plasma and factor VIII concentrate have been fractionated by continuous free film electrophoresis in an apparatus which was designed to overcome the problems of overheating usually inherent in this technique. Results show that complete separation of plasma proteins is unlikely to be obtained by a single passage ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1983.tb01877.x

    authors: Austen DE,Cartwright T,Dickerson CH

    更新日期:1983-03-01 00:00:00

  • Validation of a haemoglobin dilution method for estimation of blood loss.

    abstract:BACKGROUND AND OBJECTIVES:Analysis of haemoglobin (Hb) dilution after bleeding is a simple, inexpensive and non-invasive method to estimate blood loss. Blood volume is estimated, taking sex, weight and height into account. The Hb concentration before and after blood loss is analysed and, from the difference, the blood ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2008.01071.x

    authors: Meunier A,Petersson A,Good L,Berlin G

    更新日期:2008-08-01 00:00:00

  • Model for the Rh blood group system based on discontinuous gene structure.

    abstract::A model of the Rh blood group system is proposed which is based on discontinuous gene structure. The R29 control subregion consists of a single exon flanked by introns. Following the R29 subregion, the R1 subregion exists as seven exon structures which alternate with introns. The expression of each exon is controlled ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1981.tb01022.x

    authors: Giorno R

    更新日期:1981-01-01 00:00:00

  • Automated screening of blood donations for hepatitis C virus RNA using the Qiagen BioRobot 9604 and the Roche COBAS HCV Amplicor assay.

    abstract:BACKGROUND AND OBJECTIVES:In order to reduce the potential for transmission of hepatitis C virus (HCV) from an RNA-positive, anti-HCV-negative blood donation, the National Blood Service (NBS) introduced nucleic acid amplification technology (NAT) testing for HCV in England and Wales. The objective of this study was to ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2002.00177.x

    authors: Grant PR,Sims CM,Krieg-Schneider F,Love EM,Eglin R,Tedder RS

    更新日期:2002-05-01 00:00:00

  • Immunochemical characterization of the Rh CW antigen using human monoclonal antibodies.

    abstract:BACKGROUND AND OBJECTIVES:Human monoclonal antibodies have been produced against various Rh antigens. We report here the production of another one against Rh C and the first such antibody against Rh CW. MATERIALS AND METHODS:Two heterohybridomas secreting IgG human monoclonal antibodies against Rh CW and Rh C (MS-353 ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1997.7330174.x

    authors: Thorpe SJ,Boult CE,Thompson KM

    更新日期:1997-01-01 00:00:00

  • Lactated Ringer's solution versus hydroxyethyl starch for volume replacement in autologous blood donors with cardiovascular disease: a controlled, randomized trial.

    abstract:BACKGROUND AND OBJECTIVES:The study was designed to evaluate whether volume replacement following blood donation can prevent arterial hypotension in autologous blood donors with cardiovascular disease. MATERIALS AND METHODS:One hundred nineteen autologous blood donors with known cardiovascular disease were randomly al...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kasper SM,Dahlmann H,Mellinghoff H,Ellering J,Baumann M,Buzello W

    更新日期:1998-01-01 00:00:00

  • Safety of leucodepleted salvaged blood in oncological surgery: an in vitro model.

    abstract::Intra-operative blood cell salvage (IOCS) is mainly avoided in onco surgery due to the suspicion that it could increase metastasis' risk. We simulated IOCS followed by leucodepletion: HCT116 (human colorectal cancer) cells were inoculated into packed red blood cells units, and their distribution was evaluated, step-by...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12565

    authors: Marraccini C,Merolle L,Berni P,Boito K,Tamagnini I,Kuhn E,Ragazzi M,Baricchi R,Pertinhez TA

    更新日期:2017-11-01 00:00:00

  • Designing the blood supply chain: how much, how and where?

    abstract:BACKGROUND:The topology of the blood supply chain network can take different forms in different settings, depending on geography, politics, costs, etc. Many developed countries are moving towards centralized networks. The goal for all blood distribution networks, regardless of topology, remains the same: to satisfy dem...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12706

    authors: Osorio AF,Brailsford SC,Smith HK,Blake J

    更新日期:2018-11-01 00:00:00

  • World Health Organization collaborative study to calibrate the 3rd International Standard for Hepatitis C virus RNA nucleic acid amplification technology (NAT)-based assays.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1423-0410.2010.01434.x

    authors: Baylis SA,Heath AB,Collaborative Study Group.

    更新日期:2011-05-01 00:00:00

  • White-blood-cell-containing allogeneic blood transfusion, postoperative infection and mortality: a meta-analysis of observational 'before-and-after' studies.

    abstract:BACKGROUND AND OBJECTIVES:An association of white blood cell (WBC) reduction with decreased mortality was reported by one observational, before-and-after study. A meta-analysis was undertaken to examine whether this finding is supported by all the evidence currently available from before-and-after studies, and whether ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.0042-9007.2004.00394.x

    authors: Vamvakas EC

    更新日期:2004-02-01 00:00:00

  • Feasibility of reducing the maximum shelf life of red blood cells stored in additive solution: a dynamic simulation study involving a large regional blood system.

    abstract:BACKGROUND AND OBJECTIVE:Recent studies suggest that transfusion of old red blood cell (RBC)s, mainly those close to the 42-day maximum shelf life (MSL), is associated with increased morbi-mortality. Although there is no formal proof supporting a causal relationship, the precautionary principle asks for corrective inte...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12224

    authors: Grasas A,Pereira A,Bosch MA,Ortiz P,Puig L

    更新日期:2015-04-01 00:00:00

  • External quality assessment of noninvasive fetal RHD genotyping.

    abstract:BACKGROUND AND OBJECTIVES:Fetal RHD genotyping of cell-free maternal plasma DNA from RhD negative pregnant women can be used to guide targeted antenatal and postnatal anti-D prophylaxis for the prevention of RhD immunization. To assure the quality of clinical testing, we conducted an external quality assessment worksho...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,多中心研究

    doi:10.1111/vox.12908

    authors: Clausen FB,Hellberg Å

    更新日期:2020-07-01 00:00:00

  • Cytomegalovirus (CMV) antibody in male homosexuals: a source for CMV immune globulin.

    abstract::Male homosexuals have been found to have an extraordinarily high prevalence, and high titers, of antibodies to cytomegalovirus (CMV), as determined by complement-fixation and passive hemagglutination tests. These findings support other data suggesting that CMV may be sexually transmitted. The high titers of CMV antibo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1983.tb01881.x

    authors: Ikram H,Prince AM,Baker LN

    更新日期:1983-03-01 00:00:00

  • Perioperative red cell transfusion: evidence, guidelines and practice.

    abstract::Although we still do not know enough about the influence of anaemia and transfusion on outcomes for the surgical patient, it is possible to develop a general consensus about many aspects of management. A quality programme to improve consistency of practice in these consensus areas is feasible. (Table 6) This should be...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1998.tb05393.x

    authors: McClelland B

    更新日期:1998-01-01 00:00:00

  • Maximising platelet availability by delaying cold storage.

    abstract:BACKGROUND AND OBJECTIVES:Cold-stored platelets may be an alternative to conventional room temperature (RT) storage. However, cold-stored platelets are cleared more rapidly from circulation, reducing their suitability for prophylactic transfusion. To minimise wastage, it may be beneficial to store platelets conventiona...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12649

    authors: Wood B,Johnson L,Hyland RA,Marks DC

    更新日期:2018-04-06 00:00:00

  • Use of the MAIEA technique to confirm the relationship between the Cromer antigens and decay-accelerating factor and to assign provisionally antigens to the short-consensus repeats.

    abstract::The MAIEA (monoclonal-antibody-specific immobilisation of erythrocyte antigens) assay has recently been developed for the assignment of red cell antigens, recognised by human alloantisera, to particular membrane components of the red cell membrane. This technique detects trimolecular complexes formed by the reaction o...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1993.tb02172.x

    authors: Petty AC,Daniels GL,Anstee DJ,Tippett P

    更新日期:1993-01-01 00:00:00

  • Reduced immune phagocytosis of monocytes from neonates whose mothers produce HLA antibodies.

    abstract::In vivo immune phagocytosis of neonatal monocytes was significantly correlated to the extent of maternal HLA immunization. Monocytes from all 15 neonates of mothers with HLA antibodies show reduced immune phagocytosis. In contrast, this holds true for monocytes from only 6 out of 13 neonates of mothers without detecta...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1988.tb03896.x

    authors: Neppert J,Mueller-Eckhardt G,Heine O

    更新日期:1988-01-01 00:00:00

  • Platelet storage media.

    abstract::Present platelet storage media often designated platelet additive solutions (PAS) basically contain acetate, citrate and phosphate and recently also potassium and magnesium. However, there seems to be an increasing interest in developing PASs that can be used also after further reduction of residual plasma content bel...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/vox.12172

    authors: Gulliksson H

    更新日期:2014-10-01 00:00:00

  • A new therapeutic antibody removal method using antigen-positive red cells. II. Application to a P-incompatible pregnant woman.

    abstract::Therapeutic antibody removal using antigen-positive red cells was applied to a pregnant woman who has high titered IgG anti-P and had lost all of 4 previous fetuses in P-incompatible pregnancy. The treatment was commenced at the 6th week of gestation and was intensively performed 93 times up to the 35th week. The volu...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb01589.x

    authors: Yoshida H,Ito K,Emi N,Kanzaki H,Matsuura S

    更新日期:1984-01-01 00:00:00