Safety of leucodepleted salvaged blood in oncological surgery: an in vitro model.

Abstract:

:Intra-operative blood cell salvage (IOCS) is mainly avoided in onco surgery due to the suspicion that it could increase metastasis' risk. We simulated IOCS followed by leucodepletion: HCT116 (human colorectal cancer) cells were inoculated into packed red blood cells units, and their distribution was evaluated, step-by-step, by flow cytometry and immunohistochemistry. Most of HCT116 cells were lost during washing, and almost completely removed after filtration. IOCS plus leucodepletion could be of great advantage for oncological patients, where allogenic blood transfusion could influence tumour progression.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Marraccini C,Merolle L,Berni P,Boito K,Tamagnini I,Kuhn E,Ragazzi M,Baricchi R,Pertinhez TA

doi

10.1111/vox.12565

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

803-805

issue

8

eissn

0042-9007

issn

1423-0410

journal_volume

112

pub_type

杂志文章
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    abstract:BACKGROUND AND OBJECTIVES:To demonstrate the application of leukocyte removal filters made of a new type of filter material - superfine glass fiber - for depleting leukocytes in SAGM red cell suspensions and preventing nonhemolytic transfusion reactions. MATERIALS AND METHODS:The extent of leukocyte depletion and red ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1159/000031015

    authors: Zou Y,Sun Q,Li A,Yao F,Hu Z,Li Z L,Ma W

    更新日期:1999-01-01 00:00:00

  • Photosensitized inactivation of Plasmodium falciparum- and Babesia divergens-infected erythrocytes in whole blood by lipophilic pheophorbide derivatives.

    abstract:BACKGROUND AND OBJECTIVES:Blood transfusions can transmit parasitic infections, such as those caused by Plasmodium (malaria), Trypanosoma cruzi (Chagas' disease), and Babesia (babesiosis). A higher degree of blood transfusion safety would be reached if methods were available for inactivating such parasites. MATERIALS ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1997.7240211.x

    authors: Grellier P,Santus R,Mouray E,Agmon V,Mazière JC,Rigomier D,Dagan A,Gatt S,Schrével J

    更新日期:1997-01-01 00:00:00

  • Biochemical studies on McLeod phenotype erythrocytes.

    abstract::Red cells of the McLeod phenotype in the Kell blood group system have an acanthocytic morphology. The membrane protein composition analyzed on sodium dodecyl-sulfate-polyacrylamide gel electrophoresis, the ATP level and the activities of a large number of intracellular enzymes appear to be normal. Membranes prepared f...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1981.tb00664.x

    authors: Tang LL,Redman CM,Williams D,Marsh WL

    更新日期:1981-01-01 00:00:00

  • Assessment of methods for cytomegalovirus antibody testing of blood donations.

    abstract::As part of a programme to establish a panel of individuals with high titres of anticytomegalovirus (CMV) IgG for the production of CMV Ig, the CMV serostatus of 139 normal blood donors was determined by indirect haemagglutination assay, enzyme immunoassay, and complement fixation. The indirect haemagglutination assay ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb04137.x

    authors: Chung A,Chang W,Leung MK,Ofosu FA,Moore BP

    更新日期:1984-01-01 00:00:00

  • Rh haplotypes that make e but not hrB usually make VS.

    abstract:BACKGROUND AND OBJECTIVES:The Rh phenotypes hrB- and VS+ are both rare in Whites but more common in Blacks. The high-incidence antigen hrB is present on most red cells that are e+. The presence of VS on red cells is associated with an aberrant expression of e, often called eS. MATERIALS AND METHODS:Using conventional ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1997.00041.x

    authors: Reid ME,Storry JR,Issitt PD,Combs MR,Beal CL,Mallory DA,Blancher A

    更新日期:1997-01-01 00:00:00

  • An analysis of autologous blood donor motivational factors.

    abstract::Little is known about the patient's reasons for participating in an autologous blood (AUB) collection program. We surveyed 110 AUB donors in our hospital-based collection program. Although fear of infection from an allogeneic blood transfusion was cited by 20% of AUB donors, 68.2% indicated that their physician's reco...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1995.tb01679.x

    authors: Domen RE,Ribicki LA,Hoeltge GA

    更新日期:1995-01-01 00:00:00

  • Azapropazone-associated antibodies.

    abstract::2 patients on the drug azapropazone developed positive antiglobulin tests. Their sera were each found to contain two distinct antibodies. One was an IgG antibody, probably a drug-dependent autoantibody of the alpha-methyldopa type, but could have been related to the disease. The other was certainly a drug-dependent an...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb00095.x

    authors: Bird GW,Wingham J,Babb RG,Bacon P,Wood D

    更新日期:1984-01-01 00:00:00

  • Sensitivity of assays for the detection of HPA-1a antibodies: results of an international workshop demonstrating the impact of cation chelation from integrin αIIbβ3 on three widely used assays.

    abstract:BACKGROUND AND OBJECTIVES:HPA-1a antibodies account for 70-80% of cases of fetal-neonatal alloimmune thrombocytopenia (FNAIT) in Caucasians. However, numerous workshops have demonstrated variability in their detection. We recently showed that exposure of αIIbβ3 to ethylene diamine tetraacetic acid (EDTA) affected bindi...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12043

    authors: Allen DL,Metcalfe P,Kaplan C,Kekomaki R,de Haas M,Yusuf R,Ouwehand WH

    更新日期:2013-08-01 00:00:00

  • Validation of a haemoglobin dilution method for estimation of blood loss.

    abstract:BACKGROUND AND OBJECTIVES:Analysis of haemoglobin (Hb) dilution after bleeding is a simple, inexpensive and non-invasive method to estimate blood loss. Blood volume is estimated, taking sex, weight and height into account. The Hb concentration before and after blood loss is analysed and, from the difference, the blood ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2008.01071.x

    authors: Meunier A,Petersson A,Good L,Berlin G

    更新日期:2008-08-01 00:00:00

  • Effect of rate and delay of cooling during initial cooling process: in vitro effect on red cells.

    abstract:BACKGROUND:Whole blood is stored at room temperature (RT) until processing into components. After separation and filtration, the RCC has to be cooled from RT to +2 - 6°C. Different start times of the cooling process and different cooling rates can be encountered in daily routine. The effect of these parameters of the i...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2010.01458.x

    authors: Bontekoe IJ,van der Meer PF,de Korte D

    更新日期:2011-07-01 00:00:00

  • Molecular bases of the ABO blood groups of Indians from the Brazilian Amazon region.

    abstract::Phenotype studies of ABO blood groups in most Amerindian populations revealed the exclusive presence of group O. Since group O is the result of the absence of glycosyltransferase activity, its molecular bases may be heterogeneous. We carried out ABO blood group genotyping by analysis of DNA of 30 Indians from 2 Amazon...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1994.tb01255.x

    authors: Franco RF,Simões BP,Guerreiro JF,Santos SE,Zago MA

    更新日期:1994-01-01 00:00:00

  • Blood donations indeterminate in HIV-1 western blot analysed by IgM immunoblot and polymerase chain reaction.

    abstract::The presence of IgM antibodies to human immunodeficiency virus 1 (HIV-1) was investigated in blood donor sera which were indeterminate in anti-HIV-1 IgG Western blot testing. In 7 of 173 instances out of approximately 1,000,000 blood donation sera with an isolated anti-p24 IgG produced an anti-gp41-45 IgM immunoblot r...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1993.tb02524.x

    authors: Knüver-Hopf J,Heinze H,Lambrecht B,Mohr H,Beyer J,Schmitt H

    更新日期:1993-01-01 00:00:00

  • A private red cell antigen, Jones, causing haemolytic disease of the newborn.

    abstract::Two previously unpublished low-incidence antigens, Jones and Hol., are identical. The antigen is a dominant, autosomally inherited character that segregates independently from the loci for the ABO, MNS, Duffy and Yt blood group systems and is different from previously published infrequent antigens. The antigen is appa...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1989.tb04989.x

    authors: Reid M,Fischer ML,Green C,Rowe GP,Pfister M,Poole J,Lewis M

    更新日期:1989-01-01 00:00:00

  • Total quality management in blood transfusion.

    abstract::Quality management is an ongoing development resulting in consistency products and services and ever increasing customer satisfaction. The ultimum is Total Quality Management. Quality systems and quality management in transfusion medicine have gained considerable attention since the outbreak of the AIDS epidemic. Wher...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:

    authors: Smit-Sibinga CT

    更新日期:2000-01-01 00:00:00

  • A microtiter modification of granulocyte immunofluorescence.

    abstract::The granulocyte immunofluorescence test (GIFT) is valuable for detecting allogeneic and autologous granulocyte antibodies. However, the original tube technique (macro GIFT) requires 50-100 microliters of serum and 10(6) granulocytes with time-consuming washing steps which cause cell loss. We report a modification (mic...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00777.x

    authors: Press C,Kline WE,Clay ME,McCullough J

    更新日期:1985-01-01 00:00:00

  • Progression to AIDS in relation to clinical factors and clotting product consumption. A 14-year follow-up of a cohort of 52 Dutch HIV-1-infected haemophilic patients.

    abstract:OBJECTIVE:In order to describe the progression of HIV disease in a cohort of Dutch HIV-1-infected patients with haemophilia and to study the influence of clinical and clotting factors, we performed a 15-year longitudinal clinical and laboratory study. METHODS:The progression to AIDS in relation to type of haemophilia,...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章

    doi:

    authors: Roosendaal G,van der Schouw Y,Mauser-Bunschoten E,Borleffs J,van den Berg H

    更新日期:1998-01-01 00:00:00

  • Plasmapheresis technology.

    abstract::Manual plasmapheresis is done worldwide on both paid donors, and to a much smaller extent on volunteer donors in order to generate source plasma to be fractionated into albumin, clotting factor concentrates, and gamma globulin. Automated technology has now been developed utilizing both centrifugal, and membrane separa...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb01992.x

    authors: Gilcher RO

    更新日期:1986-01-01 00:00:00

  • Influence of granulocyte antibodies on granulocyte function.

    abstract::The following substances were tested for their influence on granulocyte function: 8 sera that contained human granulocyte-specific alloantibodies against the antigens NA1, NA2 and NB1, two HLA antisera, and the monoclonal antibodies W6/32 and CLB-FcR-gran 1. The effects examined included spontaneous and directed migra...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1993.tb03059.x

    authors: Bux J,Dickmann JO,Stockert U,Mueller-Eckhardt C

    更新日期:1993-01-01 00:00:00

  • Clinical tolerance of methylene blue virus-inactivated plasma. A randomized crossover trial in 12 healthy human volunteers.

    abstract:OBJECTIVES:Baxter's methylene blue (MB) photoinactivation of fresh frozen plasma (FFP) is a method that effectively removes any intracellular potentially infectious agent, such as prions, by filtration combined with an improved photochemical virus inactivation on a single unit of FFP. The purpose of this study was to d...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000031129

    authors: Simonsen AC,Sørensen H

    更新日期:1999-01-01 00:00:00

  • CD36 autoantibodies and thrombotic diathesis, thrombocytopenia and repeated early fetal losses.

    abstract:BACKGROUND AND OBJECTIVES:Autoantibodies to CD36, a platelet glycoprotein, have been found in patients with thrombotic thrombocytopenic purpura, and in those with lupus-like anticoagulant with thrombotic complications. MATERIALS AND METHODS:Conventional hematologic and laboratory methods were used. The patient was a p...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1997.7310046.x

    authors: Borzini P,Riva M,Nembri P,Rossi E,Pagliaro P,Vergani P,Greppi P,Tantardini P

    更新日期:1997-01-01 00:00:00

  • A new intact immunoglobulin for intravenous use stabilized by chemically modified gelatin derivatives.

    abstract::The stabilization of human immunoglobulin (IgG) by chemically modified gelatins (Haemaccel and Gelofusine) was investigated. The gelatins prevented IgG from aggregation induced by exposure to interfaces and lyophilization. The stabilization effects of the gelatins were significantly larger than those of amino acids or...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb00219.x

    authors: Tomono T,Ikeda K,Suzuki T

    更新日期:1986-01-01 00:00:00

  • Molecular basis of red cell protein antigen deficiencies.

    abstract::Blood group antigens reside on cell surface molecules of wide structural and functional diversity. Although all are serologically detectable on red blood cells, most are also expressed in non erythroid tissues, but with a few exceptions their biological role on erythrocytes and tissues often remains elusive. Deficienc...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:

    authors: Cartron JP

    更新日期:2000-01-01 00:00:00

  • Preparation of 131I-asialo-alpha1-acid glycoprotein.

    abstract::Alpha1-Acid glycoprotein (orosomucoid) was prepared from a byproduct of the ethanol plasma fractionation by means of ion-exchange procedures. Immunoelectrophoresis suggested a high degree of purity; the purified protein contained 13.5% sialic acid and 17.8% hexose. The alpha1-acid glycoprotein was modified by removal ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb02846.x

    authors: van Rijk PP,Heinsius HL,van den Hamer CJ

    更新日期:1976-01-01 00:00:00

  • Allelic subdivisions of the HLA-B12-Bw21 complex: association with Bw4 and Bw6.

    abstract::Allelic subdeterminants (or splits) of the B12-Bw21 complex were characterized by the use of highly selected antisera and cell donors. The B12 antigen was separated into two major components, Bw44 and Bw45; and possibly a third. It was shown that Bw44 is primarily an antigen of whites, and Bw45 of blacks. Of the 68 pe...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1980.tb02363.x

    authors: Mittal KK

    更新日期:1980-01-01 00:00:00

  • A Japanese multi-institutional collaborative study of antigen-positive red blood cell (RBC) transfusions in patients with corresponding RBC antibodies.

    abstract:BACKGROUND AND OBJECTIVES:It is sometimes difficult to obtain antigen-negative red blood cells (RBCs) for patients with antibodies against RBCs. However, the frequency and severity of the adverse reactions have not been well elucidated. Here, we conducted a multi-institutional collaborative study to clarify the backgro...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/vox.12906

    authors: Yamada C,Takeshita A,Ohto H,Ishimaru K,Kawabata K,Nomaguchi Y,Haraguchi Y,Abe M,Sobue K,Takenouchi H,Takadate J,Kamimura M,Katai A,Kasai D,Minami Y,Sugimoto T,Michino J,Nagai K,Kumagai M,Hasegawa Y,Ishizuka K,Oh

    更新日期:2020-07-01 00:00:00

  • Platelet concentrates. Influence of different preparative protocols on the in vitro release reaction.

    abstract::To determine what effect different preparative protocols and different platelet storage bags have on in vitro release, platelet concentrates were prepared according to two different protocols (group I: 2,200 g for 3.5 min followed by 4,900 g for 5 min; group II: 1,000 g for 9 min and 3,000 g for 20 min). The storage b...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: Snyder EL,Koerner TA Jr,Hezzey A

    更新日期:1982-01-01 00:00:00

  • Effect of periodate oxidation on specific activities and carbohydrate components of human blood group N- and M-specific glycoproteins and glycopeptides.

    abstract::Mild as well as strong periodate oxidation of isolated erythrocyte N and M glycoproteins and glycopeptides gave extensive to complete destruction of N-specificities as measured with Vicia graminea extracts and of N- as well as M- activities determined with all but 1 of 8 animal anti-N and 13 anti-M sera. Results with ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1978.tb02931.x

    authors: Springer GF,Yang HJ

    更新日期:1978-01-01 00:00:00

  • HLA-DR: serology versus restriction fragment length polymorphism.

    abstract::The results of the serological typing and the patterns of restriction fragment length polymorphisms for the detection of HLA-DR gene products are compared. The data shown demonstrate that the use of DNA typing gives a clearer definition of the HLA-DR antigens and that the HLA-DR polymorphism is greater than detected b...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1991.tb00928.x

    authors: Nagy M,Mayr WR,Menzel GR

    更新日期:1991-01-01 00:00:00

  • Current problems and results in testing microaggregate filters.

    abstract::Most in vitro studies on microaggregate filters focus on the mechanical retention of microparticles. Data are based on bulk techniques such as differential dry weight and screen filtration pressure measurements or single-particle counting using resistance measurement (Coulter principle). Errors in measurements may res...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1979.tb02310.x

    authors: Eisert WG,Eckert G

    更新日期:1979-01-01 00:00:00

  • Another Kell-related antibody, anti-K19.

    abstract::A new high-frequency antigen related to the Kell system was defined by the serum of a patient, Mrs. Sub. The antigen was lacking from her cells and those of one of her three siblings. All random cells tested were incompatible with her serum as were bloods of other various "null" phenotypes, but Ko bloods were compatib...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1979.tb04406.x

    authors: Sabo B,McCreary J,Stroup M,Smith DE,Weidner JG

    更新日期:1979-01-01 00:00:00