Abstract:
:Phenotype studies of ABO blood groups in most Amerindian populations revealed the exclusive presence of group O. Since group O is the result of the absence of glycosyltransferase activity, its molecular bases may be heterogeneous. We carried out ABO blood group genotyping by analysis of DNA of 30 Indians from 2 Amazonian tribes (Yanomami and Arara), and compared the findings with other populations (Caucasians and Blacks). Two segments of the glycosyltransferase gene were amplified by PCR and digested with KpnI or AluI to detect deletion or base change at positions 258 and 700, respectively. For all subjects, the gene basis of blood group O is the deletion of a single nucleotide at position 258 of the glycosyltransferase A gene, similar to that observed in Caucasoids and Negroids. DNA sequencing of limited regions of the gene supports this conclusion. This finding does not exclude, however, that a heterogeneity of the O allele may be revealed by a more extensive analysis.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Franco RF,Simões BP,Guerreiro JF,Santos SE,Zago MAdoi
10.1111/j.1423-0410.1994.tb01255.xsubject
Has Abstractpub_date
1994-01-01 00:00:00pages
299-301issue
3eissn
0042-9007issn
1423-0410journal_volume
67pub_type
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