Effect of rate and delay of cooling during initial cooling process: in vitro effect on red cells.

Abstract:

BACKGROUND:Whole blood is stored at room temperature (RT) until processing into components. After separation and filtration, the RCC has to be cooled from RT to +2 - 6°C. Different start times of the cooling process and different cooling rates can be encountered in daily routine. The effect of these parameters of the initial cooling of leucoreduced red cell concentrates (LR-RCC) on in vitro quality is not known. METHODS:In paired experiments (n=12), LR-RCCs in SAGM were cooled immediately after preparation from RT to +2 to +6°C either 'fast' (within 2½ h) or 'slow' (within 10-24 h) or 'slow' after a holding period of 6, 12, 18 or 24 h. Units were then stored at +2-6°C for 42 days and sampled at regular intervals for in vitro analysis. RESULTS:Irrespective of the start time and cooling rate during the initial cooling process, all units maintained good in vitro quality up to Day 42 with haemolysis <0·8%. Adenosine triphosphate (ATP) levels remained >2·7 μmol/g Hb in 99% of all units up to Day 35. Differences in pH, ATP content and 2,3-DPG content between the groups were largest at Day 2 or 3 but generally disappeared during storage. CONCLUSION:Start time and cooling rate of the initial cooling process had minor effects on in vitro quality of red cells. LR-RCCs can be stored up to 24 h before cooling down to +2-6°C without deleterious effects on in vitro parameters during 42-day storage.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Bontekoe IJ,van der Meer PF,de Korte D

doi

10.1111/j.1423-0410.2010.01458.x

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

16-20

issue

1

eissn

0042-9007

issn

1423-0410

journal_volume

101

pub_type

杂志文章
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    doi:10.1111/j.1423-0410.2006.00867.x

    authors: Sazama K

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  • The HLA system: an update and relevance to patient-donor matching strategies in clinical transplantation.

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    doi:10.1046/j.1423-0410.1996.7110006.x

    authors: Howell WM,Navarrete C

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  • Detection of a new weak A blood-group allele (Aw11).

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    doi:10.1111/j.1423-0410.2006.00752.x

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1983.tb01897.x

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  • Persistent aggregates in apheresis platelet concentrates.

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  • Molecular genetic analysis of para-Bombay phenotypes in Chinese: a novel non-functional FUT1 allele is identified.

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    authors: Yip SP,Chee KY,Chan PY,Chow EY,Wong HF

    更新日期:2002-10-01 00:00:00

  • The influence of platelet glycoprotein polymorphisms on receptor function and risk for thrombosis.

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    doi:10.1111/j.1423-0410.2002.tb05274.x

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  • A multi-centre study on the performance of the molecular genotyping platform ID RHD XT for resolving serological weak RhD phenotype in routine clinical practice.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章,多中心研究

    doi:10.1111/vox.12886

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12312

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  • Severe intravascular haemolysis in a renal transplant recipient due to anti-B of donor origin.

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1990.tb00853.x

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  • What would encourage blood donation in Ireland?

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2007.00893.x

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  • Factors influencing plasma transfusion practices in paediatric intensive care units around the world.

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    pub_type: 杂志文章

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  • Preparation of improved cryoprecipitated factor VIII concentrate. A controlled study of three variables affecting the yield.

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    doi:10.1111/j.1423-0410.1980.tb02358.x

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  • Prospective evaluation of immune haemolysis in liver transplantation.

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1987.tb04915.x

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    journal_title:Vox sanguinis

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.0042-9007.2004.00394.x

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  • Successful treatment of bleeding with tranexamic acid in a series of 12 patients with immune thrombocytopenia.

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12549

    authors: Mayer B,Salama A

    更新日期:2017-11-01 00:00:00

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    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1994.tb04541.x

    authors: McCullough J

    更新日期:1994-01-01 00:00:00

  • Stabilization of human albumin by caprylate and acetyltryptophanate.

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb01558.x

    authors: Yu MW,Finlayson JS

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  • Systematic use of leukocyte-free blood components to prevent alloimmunization and platelet refractoriness in multitransfused children with cancer.

    abstract::A major drawback in the use of platelet transfusions is the development of platelet refractoriness that is usually caused by alloimmunization provoked by leukocytes present in the blood products. We evaluated the development of alloimmunization both by serological demonstration of HLA antibodies and by clinical demons...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章

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    更新日期:1993-01-01 00:00:00

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    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1983.tb01876.x

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    更新日期:1983-03-01 00:00:00

  • Lactated Ringer's solution versus hydroxyethyl starch for volume replacement in autologous blood donors with cardiovascular disease: a controlled, randomized trial.

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

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    更新日期:1998-01-01 00:00:00

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    doi:10.1111/j.1423-0410.2007.01009.x

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    更新日期:2008-02-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00808.x

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1978.tb02889.x

    authors: Abu-Sin AY,Ayoub M,Abdelrazig H

    更新日期:1978-01-01 00:00:00

  • The D antigen characteristic of RoHar is a partial D antigen.

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    doi:10.1111/j.1423-0410.1996.tb01317.x

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    更新日期:1996-01-01 00:00:00