The HLA system: an update and relevance to patient-donor matching strategies in clinical transplantation.

abstract：BACKGROUND AND OBJECTIVES:Plasma transfusions are a frequent treatment worldwide, but many studies have reported a wide variation in the indications to transfuse. Recently, an international paediatric study also showed wide variation in frequency in the use of plasma transfusions: 25% of the centres transfused plasma t...

journal_title：Vox sanguinis

authors： Karam O,Demaret P,Duhamel A,Shefler A,Spinella PC,Tucci M,Leteurtre S,Stanworth SJ,PlasmaTV investigators.

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In previous studies, we found that platelet microparticles (PMPs) bind to cord blood (CB) CD34+ cells and transfer adhesion molecules to them, which enhances their engraftment. Before applying this phenomenon in actual transplants, we investigated the effect of PMPs on cryopreserved CD34+ cell...

journal_title：Vox sanguinis

authors： Liu B,Chen JS,Cao M,Gu SL,Liao C,Li DZ,Zhong HZ

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:This report describes a method for estimating the risk of transfusion-transmitted HBV infection attributable to blood components from donors with occult hepatitis B virus infection (OBI) applicable where universal anti-HBc screening is not performed. MATERIALS AND METHODS:In the context of pa...

journal_title：Vox sanguinis

authors： Seed CR,Kiely P

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:One of the challenges surrounding blood component administration is the determination of an appropriate rate of infusion. There are very few evidence-based guidelines available to guide healthcare providers looking for a 'standard' infusion rate for red blood cells (RBCs), plasma or platelets ...

journal_title：Vox sanguinis

authors： Gehrie EA,Hendrickson JE,Tormey CA

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Autoantibodies to CD36, a platelet glycoprotein, have been found in patients with thrombotic thrombocytopenic purpura, and in those with lupus-like anticoagulant with thrombotic complications. MATERIALS AND METHODS:Conventional hematologic and laboratory methods were used. The patient was a p...

journal_title：Vox sanguinis

authors： Borzini P,Riva M,Nembri P,Rossi E,Pagliaro P,Vergani P,Greppi P,Tantardini P

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:White blood cell (WBC) fragments may cause human leucocyte antigen (HLA) immunization in recipients. We investigated the occurrence and production of WBC fragments in platelet concentrates (PCs) and plasma units, during storage and filtration, by using real-time polymerase chain reaction (PCR)...

journal_title：Vox sanguinis

authors： Dijkstra-Tiekstra MJ,van der Schoot CE,Pietersz RN,Huijgens PC,van der Meer PF,Reesink HW

更新日期：2004-11-01 00:00:00

abstract：:Low-dose immune tolerance protocols use doses of factor VIII of less than 50 IU/kg/day to induce immune tolerance. Such protocols are chosen for a variety of reasons including cost, patient acceptability and ease of administration. Early published reports of low-dose protocols appeared in 1981, described small numbers...

journal_title：Vox sanguinis

authors： Sultan Y

更新日期：1999-01-01 00:00:00

abstract：:Prothrombin complex concentrates prepared for clinical use are reviewed with emphasis on frequently observed adverse reactions such as viral hepatitis and thromboembolic complications. Preparation procedures and quality control are described briefly, and the use of these concentrates in the treatment of hemophilia A p...

journal_title：Vox sanguinis

authors： Chandra S,Brummelhuis HG

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:GB virus C (GBV-C)/hepatitis G virus (HGV) is a recently recognized parenterally and sexually transmitted agent. The prevalence of GBV-C/HGV markers in Canadian blood donors has not been previously studied and was therefore determined. MATERIALS AND METHODS:Blood donors [identity unlinked (IU...

journal_title：Vox sanguinis

authors： Giulivi A,Slinger R,Tepper M,Sher G,Scalia V,Kessler G,Gill P

更新日期：2000-01-01 00:00:00

abstract：:Manual plasmapheresis is done worldwide on both paid donors, and to a much smaller extent on volunteer donors in order to generate source plasma to be fractionated into albumin, clotting factor concentrates, and gamma globulin. Automated technology has now been developed utilizing both centrifugal, and membrane separa...

journal_title：Vox sanguinis

authors： Gilcher RO

更新日期：1986-01-01 00:00:00

abstract：:This study reports the adaptation of an electronic particle-counting method for the enumeration of T cell and B cell rosettes of human lymphocytes. This method and the conventional hemocytometer method were compared in parallel on seventeen T cell and seven B cell rosette enumerations in a blind study design. All data...

journal_title：Vox sanguinis

authors： Denny TN,Kinsley KM,Benson JW,Bull RW

更新日期：1979-01-01 00:00:00

abstract：:We studied 684 sera obtained from 20 hemophilia patients with AIDS/AIDS-related complex (ARC), 89 asymptomatic HIV+, 76 HIV- hemophilia patients and 151 healthy controls for antibodies against recombinant CD4 (rCD4). Twenty-two percent of AIDS/ARC patients, 10% of asymptomatic HIV+ patients, 17% of HIV-patients, and 1...

journal_title：Vox sanguinis

authors： Daniel V,Weimer R,Zettlmeissl G,Langner K,Zimmermann R,Opelz G

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Red-blood-cell (RBC) transfusion is associated with lung injury, which is further exacerbated by mechanical ventilation. Manufacturing methods of blood products differ globally and may play a role in the induction of pulmonary cell activation through alteration of the immunomodulatory property...

journal_title：Vox sanguinis

authors： Wirtz MR,Almizraq RJ,Weber NC,Norris PJ,Pandey S,Spinella PC,Muszynski JA,P Acker J,Juffermans NP

更新日期：2020-07-01 00:00:00

abstract：:A competitive inhibition assay for functional fibronectin (Fn), based on ELISA technology, is described. The assay measures Fn's physiologic ability to bind to denatured collagen (gelatin). Affinity-purified Fn inhibits the binding of alkaline phosphatase coupled Fn to gelatin-coated wells of a microtiter plate in a c...

journal_title：Vox sanguinis

authors： Doran JE,Callaway BD,Reese AC,Wynn JJ,Mansberger AR

更新日期：1983-01-01 00:00:00

abstract：:This report describes a case of persistent polyagglutinability restriced to the red blood cells, and associated with hemolytic anemia in a 20-year-old male. AIME WITH NORMAL INTERVALS. His red blood cells were weakly agglutinated by almost all adult sera. No autoagglutination was noted and the direct antihuman globuli...

journal_title：Vox sanguinis

authors： Graninger W,Rameis H,Fischer K,Poschmann A,Bird GW,Wingham J,Neumann E

更新日期：1977-01-01 00:00:00

abstract：:Experiments have shown that suitably diluted, unpurified IgA paraprotein sera can be substituted for chemically purified IgA proteins in the passive haemagglutination test for the detection of anti-IgA antibodies. The substitution of unpurified IgA paraprotein was made possible by the enhanced serological activity obt...

journal_title：Vox sanguinis

authors： Hunt A,Reed M

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Severe anaemia is an important cause of mortality in developing countries. However, few studies have explored the use of and possibilities for blood transfusion services. The aims of this study are to explore the use of blood transfusion services at a hospital in sub-Saharan Africa and to asse...

journal_title：Vox sanguinis

authors： Bugge HF,Karlsen NC,Oydna E,Rake MM,Wexels N,Bendabenda J,Roald B,Heier HE,Chisuwo L,Jourdan PM

更新日期：2013-01-01 00:00:00

abstract：:A Du variant negro woman developed, during pregnancy, an anti-D that was unusual in that it bound complement. The Rh groups of the propositus and other members of her family were also unusual. ...

journal_title：Vox sanguinis

authors： Ayland J,Horton MA,Tippett P,Waters AH

更新日期：1978-01-01 00:00:00

abstract：:A new competitive solid phase radioimmunoassay (CLB-RIA) has been developed for the detection of HBAg and HBAb in human serum and plasma. In the assay, sheep antibodies to HBAg, covalently linked to an insoluble carrier, highly purified 125-I labelled HBAg and the serum or plasma sample are incubated for 20 h at room ...

journal_title：Vox sanguinis

authors： Duimel WJ,Brummelhuis HG

更新日期：1975-01-01 00:00:00

abstract：:Native hemoglobin in the form of stroma-free hemoglobin cannot be used as blood substitute. Hemoglobin has to be modified either molecularly or encapsulated. First generation molecularly modified ultrapure hemoglobins are now in clinical trial--some in Phase III. There are a number of these. Polyhemoglobin is formed b...

journal_title：Vox sanguinis

authors： Chang TM

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Fetal RHD genotyping of cell-free maternal plasma DNA from RhD negative pregnant women can be used to guide targeted antenatal and postnatal anti-D prophylaxis for the prevention of RhD immunization. To assure the quality of clinical testing, we conducted an external quality assessment worksho...

journal_title：Vox sanguinis

authors： Clausen FB,Hellberg Å

更新日期：2020-07-01 00:00:00

abstract：:Direct immunofluorescent staining of 31 specimens of platelets obtained from 13 cases of idiopathic thrombocytopenic purpura (ITP) revealed positive staining on the surface of platelets for both immunoglobulins (Igs) and human B1C globulin in 9 specimens, for only Igs in 1 specimen and for human B1C alone in 5 specime...

journal_title：Vox sanguinis

authors： Boonpucknavig S,Vuttivirojana O,Srichaikul T

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:In order to describe the progression of HIV disease in a cohort of Dutch HIV-1-infected patients with haemophilia and to study the influence of clinical and clotting factors, we performed a 15-year longitudinal clinical and laboratory study. METHODS:The progression to AIDS in relation to type of haemophilia,...

journal_title：Vox sanguinis

authors： Roosendaal G,van der Schouw Y,Mauser-Bunschoten E,Borleffs J,van den Berg H

更新日期：1998-01-01 00:00:00

abstract：:Immunoblotting with human anti-Sc1 and anti-Sc2 locates the Sc1 and Sc2 antigens to an erythrocyte membrane glycoprotein of apparent Mr 60,000. The antigens are destroyed by pronase, and require intact disulphide bonds for expression. A proportion of the molecules carrying the Sc1 and Sc2 antigens are associated with ...

journal_title：Vox sanguinis

authors： Spring FA,Herron R,Rowe G

更新日期：1990-01-01 00:00:00

abstract：:Hepatitis A virus (HAV) infections have been reported among hemophiliacs who received factor VIII concentrates which had been purified by ion-exchange chromatography and treated by the solvent detergent (SD) method. Since the virus inactivation procedure of our manufacturing process is heat treatment of the stabilized...

journal_title：Vox sanguinis

authors： Hilfenhaus J,Nowak T

更新日期：1994-01-01 00:00:00

abstract：:Recessively inherited ovalocytosis in coastal Melanesians is associated with widespread, but selective, depression of blood group antigens in homozygotes, who comprise about 15% of these populations. It is suggested that a membrane anomaly exists, and that the series of depressed determinants all depend, for their ful...

journal_title：Vox sanguinis

authors： Booth PB,Serjeantson S,Woodfield DG,Amato D

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:The Mirasol Pathogen Reduction Technology System (PRT) for Plasma (CaridianBCT) is based on a riboflavin and UV light treatment process resulting in pathogen inactivation due to irreversible, photochemically induced damage of nucleic acids. This study evaluated the in vitro protein quality of plasma products...

journal_title：Vox sanguinis

authors： Bihm DJ,Ettinger A,Buytaert-Hoefen KA,Hendrix BK,Maldonado-Codina G,Rock G,Giclas PC,Goodrich RP

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transfusion based on the Thrombelastograph (TEG) results reduces transfusion requirements in cardiac surgery and in liver transplantation. Taking the pivotal role of thrombin generation in the coagulation process into consideration, the clinical utility of the TEG may, in part, depend on its r...

journal_title：Vox sanguinis

authors： Johansson PI,Svendsen MS,Salado J,Bochsen L,Kristensen AT

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Antibodies to antigens in the Kell blood group system, especially anti-KEL1, are involved in both haemolytic disease of the newborn and foetus and haemolytic transfusion reactions. Correct typing results are important and discrepancies between serologic and genetic typing must be resolved. Her...

journal_title：Vox sanguinis

authors： Wester ES,Steffensen R,Ligthart PC,Vad J,de Haas M,Storry JR,Olsson ML

更新日期：2010-08-01 00:00:00

abstract：:Plasmodium falciparum malaria has long been a killer of the young, and has selected for polymorphisms affecting not only erythrocytes, but the immunogenetics of three histocompatibility systems: ABO, human leukocyte antigen (HLA), and CD36. The ABO system is important because the original allele, encoding glycosylatio...

journal_title：Vox sanguinis

authors： Cserti-Gazdewich CM,Mayr WR,Dzik WH

更新日期：2011-01-01 00:00:00