Factors influencing plasma transfusion practices in paediatric intensive care units around the world.


BACKGROUND AND OBJECTIVES:Plasma transfusions are a frequent treatment worldwide, but many studies have reported a wide variation in the indications to transfuse. Recently, an international paediatric study also showed wide variation in frequency in the use of plasma transfusions: 25% of the centres transfused plasma to >5% of their patients, whereas another 25% transfused plasma to <1% of their patients. The objective of this study was to explore the factors associated with different plasma transfusion practices in these centres. MATERIALS AND METHODS:Online survey sent to the local investigators of the 101 participating centres, in February 2016. Four areas were explored: beliefs regarding plasma transfusion, patients' case-mix in each unit, unit's characteristics, and local blood product transfusion policies and processes. RESULTS:The response rate was 82% (83/101). 43% of the respondents believed that plasma transfusions can arrest bleeding, whereas 27% believe that plasma transfusion can prevent bleeding. Centres with the highest plasma transfusion rate were more likely to think that hypovolaemia and mildly abnormal coagulation tests are appropriate indications for plasma transfusions (P = 0·02 and P = 0·04, respectively). Case-mix, centre characteristics or local transfusion services were not identified as significant relevant factors. CONCLUSION:Factors influencing plasma transfusion practices reflect beliefs about indications and the efficacy of transfusion in the prevention and management of bleeding as well as effects on coagulation tests. Educational and other initiatives to target these beliefs should be the focus of research.


Vox Sang


Vox sanguinis


Karam O,Demaret P,Duhamel A,Shefler A,Spinella PC,Tucci M,Leteurtre S,Stanworth SJ,PlasmaTV investigators.




Has Abstract


2017-02-01 00:00:00












  • Oversight and monitoring of blood safety in the United States.

    abstract::The US blood safety vigilance system is composed of a network of interwoven programs, now organized under a formal structure, with the Assistant Secretary of Health and DHHS Blood Safety Committee bearing overall responsibility. It takes advantage of the breadth of expertise and close collaborative relationship of tra...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审


    authors: Busch M,Chamberland M,Epstein J,Kleinman S,Khabbaz R,Nemo G

    更新日期:1999-01-01 00:00:00

  • Necrotizing enterocolitis in haemolytic disease of the newborn: a retrospective cohort study.

    abstract:BACKGROUND AND OBJECTIVES:Necrotizing enterocolitis (NEC) is a common and often severe gastrointestinal emergency in newborn infants. While usually affecting (very) premature infants, an association between NEC and haemolytic disease of the foetus and newborn (HDFN) has been suggested. HDFN may be an additional risk fa...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Ree IMC,de Grauw AM,Bekker V,de Haas M,Te Pas AB,Oepkes D,Middeldorp AJM,Lopriore E

    更新日期:2020-02-01 00:00:00

  • Polymorphism of the second component of human complement (C2). Observation of the rare phenotype (C2 2 (= C2 B) and data on the localization of the C2 locus in the HLA region.

    abstract::The polymorphism of the second component of human complement was studied by means of isoelectric focusing in polyacrylamide gels with subsequent complement-dependent lysis of sensitized sheep erythrocytes in an agarose overlay containing C2-deficient or normal human serum. In a material of 289 unrelated individuals th...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Dewald G,Rittner C

    更新日期:1979-01-01 00:00:00

  • Supernatants of stored polymorphonuclear neutrophils exhibit growth-promoting activity in several cell lines: perforin expression in polymorphonuclear neutrophils and its role in down-regulation of growth-promoting activity.

    abstract:BACKGROUND AND OBJECTIVES:Polymorphonuclear neutrophils (PMNs) play important roles in the host immune defence. This study was performed to identify roles of PMNs other than those already known. MATERIALS AND METHODS:PMNs were separated from the peripheral blood of healthy individuals and stored in vitro for 24 h in t...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Nishimura M,Mitsunaga S,Juji T

    更新日期:2002-04-01 00:00:00

  • Platelet function abnormalities in qualified whole-blood donors: effects of medication and recent food intake.

    abstract:BACKGROUND AND OBJECTIVES:Platelet function abnormalities have been reported in blood donors who have not consumed aspirin. Our objective was to identify factors other than aspirin that may contribute to impaired platelet function in qualified volunteer blood donors. MATERIALS AND METHODS:Blood samples were obtained f...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Paglieroni TG,Janatpour K,Gosselin R,Crocker V,Dwyre DM,MacKenzie MR,Holland PV,Larkin EC

    更新日期:2004-01-01 00:00:00

  • Autoimmune haemolytic anaemia due to anti-phospholipid antibodies.

    abstract::The clinical course and laboratory findings of a patient with autoimmune haemolytic anaemia due to anti-phospholipid antibodies and secondary to a systemic lupus erythematosus-like syndrome are described. IgG and IgM with anti-phospholipid activity coexisted in both sera and acid eluates prepared from the patient's re...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Arvieux J,Schweizer B,Roussel B,Colomb MG

    更新日期:1991-01-01 00:00:00

  • pH, temperature and lactate production in human red blood cells: implications for blood storage and glycolytic control.

    abstract::The interaction of temperature and pH in biological systems comprises two components. Temperature change may perturb the pH of solutions, and it may change the pKa of some ionizable groups that are involved in enzyme catalysis. The pH optima of single reactions and whole pathways are therefore temperature sensitive. T...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Guppy M,Attwood PV,Hansen IA,Sabaratnam R,Frisina J,Whisson ME

    更新日期:1992-01-01 00:00:00

  • Platelet transfusions in haematologic malignancies in the last six months of life.

    abstract:BACKGROUND AND OBJECTIVES:Practices in end-of-life platelet transfusions in haematologic malignancies are variable. Our aim was to describe the platelet transfusion burden and parameters linked to this indication in such a setting and thereby contribute to defining optimal practices. MATERIALS AND METHODS:From July 20...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Moracchini J,Seigeot A,Angelot-Delettre F,Vienot A,Aubry R,Daguindau É,Deconinck E,Frache S,Tiberghien P

    更新日期:2020-08-13 00:00:00

  • Detection of anti-Lea in Le(a-b+) individuals by kinetic ELISA.

    abstract::Utilizing a kinetic enzyme-linked antiglobulin binding assay, eight examples of anti-Lea were detected in individuals whose Lewis phenotype is Le(a-b+). These antibodies were not detectable by routine hemagglutination techniques, but were indistinguishable from anti-Lea made by Le(a-b-) individuals in terms of their i...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Cowles JW,Spitalnik SL,Blumberg N

    更新日期:1986-01-01 00:00:00

  • Evaluation of a new microporous filtration membrane system for therapeutic plasma exchange.

    abstract::A new therapeutic plasma exchange device developed by Sarns Inc./3M was evaluated in plasmapheresis of 20 healthy volunteers and in a multicenter clinical study of therapeutic plasma exchange that included 49 patients. Safety and efficacy of plasma separation from whole blood were assessed for a module that contains D...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Kurtz SR,Carey PM,McGill M,Pineda AA,Zaroulis CG,Case MT

    更新日期:1987-01-01 00:00:00

  • Hemostasis testing during massive blood replacement. A study of 172 cases.

    abstract::A 24-hours service was organized to study changes in the hemostatic system in surgical patients undergoing massive transfusion for excessive bleeding during operation or in the early postoperative period. Hemostasis tests gave normal results in only 12(7%) of the 172 patients, while in the remaining 160(93%) one or mo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Mannucci PM,Federici AB,Sirchia G

    更新日期:1982-03-01 00:00:00

  • Rationale for randomized controlled trials and for intention-to-treat analysis in transfusion medicine: are they one and the same?

    abstract::Articles on the appropriateness of intention-to-treat (ITT) vs. as-treated (AT) analyses of randomized controlled trials (RCTs) have highlighted issues relevant to drug trials, such as approaches suitable for 'explanatory' vs. 'pragmatic' RCTs. These considerations are less relevant to transfusion medicine RCTs, espec...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审


    authors: Vamvakas EC

    更新日期:2008-10-01 00:00:00

  • Management of fetal alloimmune thrombocytopenia by weekly in utero platelet transfusions.

    abstract::Alloimmune neonatal thrombocytopenia (ANT) may cause intracranial haemorrhage in utero as well as at delivery. Recent management has concentrated on attempts to minimise fetal thrombocytopenia and prevent its complications. This report describes further experience with the use of repeated intravascular transfusions of...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Murphy MF,Pullon HW,Metcalfe P,Chapman JF,Jenkins E,Waters AH,Nicolaides KH,Mibashan RS

    更新日期:1990-01-01 00:00:00

  • Competition between ABO and Le gene specified enzymes. I. A Lewis related difference in the amount of A antigen in saliva of A1 and A2 secretors.

    abstract::Radioimmunoassays were prepared using two anti-A and one anti-B reagents. The specificity of the procedures was assessed with 13 artificial antigens. The amounts of A and B natural antigens in saliva of ABH secretors of known Lewis phenotype were measured with these assays. The results confirmed that the average amoun...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Le Pendu J,Lemieux RU,Dalix AM,Lambert F,Oriol R

    更新日期:1983-01-01 00:00:00

  • Expression of genetic markers of erythrocyte immunoglobulin G autoantibodies in autoimmune hemolytic anemia.

    abstract::The Gm allotype constitution of the autoantibody molecules and the serum Gm phenotypes were determined in 19 patients with autiommune hemolytic anemia of IgG type. The results showed that the known heterogeneity of the antierythrocyte autoantibodies in this disease concerns not only the immunoglobulin class and the is...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Le Petit JC,Rivat L,François N,Ropartz C,Brizard CP

    更新日期:1976-01-01 00:00:00

  • A Japanese multi-institutional collaborative study of antigen-positive red blood cell (RBC) transfusions in patients with corresponding RBC antibodies.

    abstract:BACKGROUND AND OBJECTIVES:It is sometimes difficult to obtain antigen-negative red blood cells (RBCs) for patients with antibodies against RBCs. However, the frequency and severity of the adverse reactions have not been well elucidated. Here, we conducted a multi-institutional collaborative study to clarify the backgro...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Yamada C,Takeshita A,Ohto H,Ishimaru K,Kawabata K,Nomaguchi Y,Haraguchi Y,Abe M,Sobue K,Takenouchi H,Takadate J,Kamimura M,Katai A,Kasai D,Minami Y,Sugimoto T,Michino J,Nagai K,Kumagai M,Hasegawa Y,Ishizuka K,Oh

    更新日期:2020-07-01 00:00:00

  • Selective depression of blood group antigens associated with hereditary ovalocytosis among melanesians.

    abstract::Recessively inherited ovalocytosis in coastal Melanesians is associated with widespread, but selective, depression of blood group antigens in homozygotes, who comprise about 15% of these populations. It is suggested that a membrane anomaly exists, and that the series of depressed determinants all depend, for their ful...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Booth PB,Serjeantson S,Woodfield DG,Amato D

    更新日期:1977-01-01 00:00:00

  • The non-Mendelian inheritance of Lewis-c blood group substance, as demonstrated in the case of a Bombay, Le(a-b-c-) saliva.

    abstract::A Bombay, Le(a-b-) saliva was shown to lack Pneumococcus type XIV activity, an unusual situation, since this sample should be rich in this precursor to the ABO blood group substances. However, the sample was found to contain a new serological specificity, Le-c. It is argued that simple Mendelian inheritance does not o...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Savvas RS

    更新日期:1975-01-01 00:00:00

  • The contribution of von Willebrand factor-GPIbα interactions to persistent aggregate formation in apheresis platelet concentrates.

    abstract:BACKGROUND AND OBJECTIVES:Apheresis platelet concentrates sometimes contain persistent aggregates (PA). Because apheresis involves extracorporeal circulation, we hypothesized that interactions between GPIbα and von Willebrand factor (VWF) underlie their origin. MATERIALS AND METHODS:Platelets in donations with PA were...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Feys HB,Van Aelst B,Devloo R,Vandekerckhove P,Compernolle V

    更新日期:2016-05-01 00:00:00

  • Rare and transient anti-D antibody response in D(-) liver transplant recipients transfused with D(+) red blood cells.

    abstract::A retrospective analysis was conducted on 20 D(-) liver transplant (LT) recipients transfused with D(+) RBCs perioperatively and screened for RBC antibodies between 2 and 6 months later. None developed anti-D detectable by the indirect antiglobulin test. Two patients produced weak anti-D that reacted only with papain-...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Burin des Roziers N,Ibanez C,Samuel D,Francoz C,Idri S,François A,Mortelecque R,Bierling P,Pirenne F

    更新日期:2016-07-01 00:00:00

  • White blood cell fragments in platelet concentrates prepared by the platelet-rich plasma or buffy-coat methods.

    abstract:BACKGROUND AND OBJECTIVES:White blood cell (WBC) fragments in platelet concentrates (PCs) may induce allo-immunization in the recipient. MATERIALS AND METHODS:As the level of WBC fragments can differ between PCs produced using different methods, we compared PCs prepared by using the buffy-coat method (BC-PCs) in plasm...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Dijkstra-Tiekstra MJ,van der Schoot CE,Pietersz RN,Reesink HW

    更新日期:2005-05-01 00:00:00

  • Effect of periodate oxidation on specific activities and carbohydrate components of human blood group N- and M-specific glycoproteins and glycopeptides.

    abstract::Mild as well as strong periodate oxidation of isolated erythrocyte N and M glycoproteins and glycopeptides gave extensive to complete destruction of N-specificities as measured with Vicia graminea extracts and of N- as well as M- activities determined with all but 1 of 8 animal anti-N and 13 anti-M sera. Results with ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Springer GF,Yang HJ

    更新日期:1978-01-01 00:00:00

  • Hepatitis E in transfusion-dependent thalassaemia patients, in Greece: a single centre experience.

    abstract::Hepatitis E is considered an emerging disease that may be a threat in both developing and industrialized countries all over the world. The risk of chronic hepatitis E virus infection is higher among immunocompromised patients. This study aimed to assess the status of hepatitis E infection in patients with transfusion-...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Klonizakis P,Gioula G,Exindari M,Apostolou C,Kotsiafti A,Vlachaki E

    更新日期:2017-10-01 00:00:00

  • Use of capillary blood count parameters in adults.

    abstract:BACKGROUND AND OBJECTIVES:Capillary samples can provide blood for cell counts in haematologic patients and blood donors. However, some accept only values from venous blood. This study compares capillary and venous blood counts to verify the hypothesis that they are equivalent. MATERIALS AND METHODS:We analysed 463 cap...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Schalk E,Heim MU,Koenigsmann M,Jentsch-Ullrich K

    更新日期:2007-11-01 00:00:00

  • Donor selection in Japan: a trial of new criteria with predonation haemoglobin testing.

    abstract:BACKGROUND AND OBJECTIVES:In Japan, eligibility for blood donation depends on blood specific gravity, which does not directly measure blood haemoglobin. Additionally, the criteria are not based on normal values. Therefore, we investigated the feasibility of predonation screening by using actual haemoglobin levels, and ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Shimoyama R,Nakase T,Kojima S,Tanaka S,Yamamori K,Kaneko C,Ishimaru K,Ikeda H

    更新日期:2002-02-01 00:00:00

  • Alloimmunization against Iy, a low-frequency antigen on platelet glycoprotein Ib/IX as a cause of severe neonatal alloimmune thrombocytopenic purpura.

    abstract::Neonatal alloimmune thrombocytopenia (NAIT) is usually induced by platelet-specific antibodies against HPA-1a (Zwa) or HPA-5b (Bra). Recently, low-frequency alloantigens on the platelet glycoprotein (GP) IIb/IIIa complex have been discovered as a cause for NAIT. In this report, a new low-frequency platelet-specific al...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Kiefel V,Vicariot M,Giovangrandi Y,Kroll H,Böhringer M,Greinacher A,Breitfeld C,Santoso S,Mueller-Eckhardt C

    更新日期:1995-01-01 00:00:00

  • Haemolytic disease of the fetus and newborn.

    abstract::Haemolytic Disease of the Fetus and Newborn (HDFN) is caused by maternal alloimmunization against red blood cell antigens. In severe cases, HDFN may lead to fetal anaemia with a risk for fetal death and to severe forms of neonatal hyperbilirubinaemia with a risk for kernicterus. Most severe cases are caused by anti-D,...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审


    authors: de Haas M,Thurik FF,Koelewijn JM,van der Schoot CE

    更新日期:2015-08-01 00:00:00

  • Molecular basis of red cell protein antigen deficiencies.

    abstract::Blood group antigens reside on cell surface molecules of wide structural and functional diversity. Although all are serologically detectable on red blood cells, most are also expressed in non erythroid tissues, but with a few exceptions their biological role on erythrocytes and tissues often remains elusive. Deficienc...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审


    authors: Cartron JP

    更新日期:2000-01-01 00:00:00

  • Collaborative study to calibrate hepatitis C virus genotypes 2-6 against the HCV International Standard, 96/790 (genotype 1).

    abstract:BACKGROUND AND OBJECTIVES:A major requirement of a hepatitis C virus (HCV) RNA nucleic acid amplification technology (NAT) assay validation is the ability of the assay to detect the six major genotypes of HCV with equivalent sensitivities. The aim of this study was to characterize and calibrate an HCV genotype panel fo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Saldanha J,Heath A,Collaborative Study Group.

    更新日期:2003-01-01 00:00:00

  • In vivo behaviour of gamma globulin preparations.

    abstract::Metabolic properties of standard gamma globulin (St-GG) and of several gamma globulin (GG) preparations for intravenous use were analyzed in radioactive tracer studies. The in vivo behaviour of St-GG was investigated in 16 probands and found to be comparable to that of normal IgG. The kinetics of the resorption of St-...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Morell A,Schürch B,Ryser D,Hofer F,Skvaril F,Barandun S

    更新日期:1980-01-01 00:00:00