Abstract:
BACKGROUND AND OBJECTIVES:In previous studies, we found that platelet microparticles (PMPs) bind to cord blood (CB) CD34+ cells and transfer adhesion molecules to them, which enhances their engraftment. Before applying this phenomenon in actual transplants, we investigated the effect of PMPs on cryopreserved CD34+ cells in CB. MATERIALS AND METHODS:We cryopreserved 18 CB units, then evaluated the binding of PMPs to CD34+ cells after thawing, by varying the expression of platelet characteristic antigens (CD41a, CD61, CD62P and CXCR4) on these cells. Adherence of the CD34+ cells, coated with freeze/thaw-induced PMPs, to endothelium and fibronectin was also studied, as were the effects of thrombin-induced PMPs from both fresh and preserved CB platelets. RESULTS:PMPs induced by freezing and thawing adhered less well to CD34+ cells than did those from fresh CB, and cells coated with these PMPs had poor adherence. However, thrombin-induced PMPs from both fresh and preserved CB platelets bound equally well to cryopreserved CD34+ cells and improved their adhesion properties. CONCLUSIONS:PMPs could be a useful tool for enhancing engraftment after CB transplantation.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Liu B,Chen JS,Cao M,Gu SL,Liao C,Li DZ,Zhong HZdoi
10.1111/j.1423-0410.2004.00538.xsubject
Has Abstractpub_date
2004-08-01 00:00:00pages
96-104issue
2eissn
0042-9007issn
1423-0410pii
VOX538journal_volume
87pub_type
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