Abstract:
:Using monoclonal antibodies to C3 it has been shown that the red blood cells of patients with cold haemagglutinin disease carry on their cells C3d,g (alpha-2D-globulin) rather than C3d. C3d,g seems to be the final product of in vivo C3 activation in fluid phase and on red cells. The cleavage of C3dg to C3d and C3g does not appear to occur in vivo either in the fluid phase or on red cell bound C3bi. In vitro C3-coated red cells prepared by antibody or low ionic strength techniques produce cells with C3d and C3bi as the predominant C3 fragment, whereas the Fruitstone technique in which coating occurs by the alternative pathway has principally C3b. The activity of C3 cleaving enzymes in whole serum is strongly influenced by the ionic conditions of the serum.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Lachmann PJ,Voak D,Oldroyd RG,Downie DM,Bevan PCdoi
10.1111/j.1423-0410.1983.tb01928.xsubject
Has Abstractpub_date
1983-01-01 00:00:00pages
367-72issue
5eissn
0042-9007issn
1423-0410journal_volume
45pub_type
杂志文章相关文献
VOX SANGUINIS文献大全abstract:BACKGROUND AND OBJECTIVE:Recent studies suggest that transfusion of old red blood cell (RBC)s, mainly those close to the 42-day maximum shelf life (MSL), is associated with increased morbi-mortality. Although there is no formal proof supporting a causal relationship, the precautionary principle asks for corrective inte...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12224
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The aim of the study was to evaluate lyophilized monoclonal IgM anti-A and anti-B preparations for use as international standards (IS) to specify recommended minimum potencies of anti-A and anti-B blood grouping reagents in tube tests. MATERIALS AND METHODS:The candidate IS for minimum potenc...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.2006.00834.x
更新日期:2006-11-01 00:00:00
abstract::Blood transfusion is used as a life-saving and prophylactic treatment in sickle cell disease. Despite the many complications associated with its use, few randomised controlled trials and careful research studies have been performed to fully define its role. This subjects is, therefore, discussed in the context of the ...
journal_title:Vox sanguinis
pub_type: 杂志文章,评审
doi:10.1111/j.1423-0410.1995.tb03916.x
更新日期:1995-01-01 00:00:00
abstract::Serum IgE was determined by radioimmunoassay in 28 subjects affected by homozygous beta thalassemia (14 males and 14 females, aged 3-19 years, mean age 7 +/- 5.6 years). They were given transfusions with packed red cells and chelant therapy. Blood samples were taken just before a transfusion (basal value) and at 10-da...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1983.tb01931.x
更新日期:1983-01-01 00:00:00
abstract::A competitive inhibition assay for functional fibronectin (Fn), based on ELISA technology, is described. The assay measures Fn's physiologic ability to bind to denatured collagen (gelatin). Affinity-purified Fn inhibits the binding of alkaline phosphatase coupled Fn to gelatin-coated wells of a microtiter plate in a c...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1983.tb01910.x
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is a member of the coronavirus family. Coronavirus infections in humans are typically associated with respiratory illnesses; however, viral RNA has been isolated in...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12937
更新日期:2020-08-01 00:00:00
abstract::To obtain red cell populations of increasing mean age erythropoiesis was arrested through continuous actinomycin treatment or maintained transfusion polycythemia in mice and rats respectively. The parameters studied included cell indices, enzyme activities and rheological characteristics. Further, the life-span of age...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1976.tb02809.x
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In Japan, eligibility for blood donation depends on blood specific gravity, which does not directly measure blood haemoglobin. Additionally, the criteria are not based on normal values. Therefore, we investigated the feasibility of predonation screening by using actual haemoglobin levels, and ...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1046/j.0042-9007.2001.00145.x
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:The Joint Commission lists improving staff communication (handoffs) as part of several National Safety Goals. In this study, we developed an electronic web-based charting system for clinical pathology handoffs, which primarily consist of transfusion medicine calls, and evaluated the advantages over a paper-b...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12913
更新日期:2020-07-01 00:00:00
abstract::In a prospective study of 50 recipients of HBsAg-negative blood who had undergone cardiac surgery, 4 (8%) developed acute non-A, non-B hepatitis. The patients who developed hepatitis had received significantly more units of blood or blood products than the patients who had no hepatitis. The incubation period of the di...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1983.tb01919.x
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVES:We have developed and optimised a new flow-cytometric method for the measurement of the Fc function of intravenous immunoglobulin (IVIg) preparations, which is important in predicting the effector function of immunoglobulin (Ig) in such preparations. MATERIALS AND METHODS:Ig was bound to a monocytic cell li...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1159/000031178
更新日期:2000-01-01 00:00:00
abstract::This report describes the recovery of highly purified immune-serum globulin (ISG) from the 42% ethanol precipitate fraction (42% P) generated during the first step of albumin purification. The method consists of three purification steps: (1) reprecipitation of the 42% P at 20% ethanol, pH 7.2; (2) solubilization of IS...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1981.tb00706.x
更新日期:1981-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Our post-thaw cell recovery rates differed substantially in interlaboratory comparisons of identical samples, potentially due to different temperatures during cell staining. MATERIALS AND METHODS:Viable CD34(+) cells and leucocyte (WBC) subtypes were quantified by multiparameter single-platfo...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12398
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Variant RHD genes associated with the weak D phenotype can result in complete or partial D-epitope expression on the red cell. This study examines the genetic classification in Australian blood donors with a weak D phenotype and correlates RHD variants associated with the weak D phenotype agai...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/vox.12488
更新日期:2017-04-01 00:00:00
abstract::63 Rh-negative male volunteers were immunized with D-positive red cells. 28 (44%) produced anti-D. To provide sustained levels of high concentration of anti-D, 18 of the 28 male volunteers have received repeated antigenic stimuli at individual intervals of 2-9 months. In all but 1 case the level of anti-D rose to betw...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1978.tb02953.x
更新日期:1978-01-01 00:00:00
abstract::We have employed a PCR approach to determine the nucleotide sequences of the coding region in the last two coding exons of the histo-blood group ABO genes from one A(X) and one B(A) individual. Compared with A1 alleles, the (A(X)) allele has a single nucleotide substitution (T-->A at nucleotide 646) resulting in an am...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1993.tb05157.x
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In previous studies, we found that platelet microparticles (PMPs) bind to cord blood (CB) CD34+ cells and transfer adhesion molecules to them, which enhances their engraftment. Before applying this phenomenon in actual transplants, we investigated the effect of PMPs on cryopreserved CD34+ cell...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.2004.00538.x
更新日期:2004-08-01 00:00:00
abstract::A group A1 diabetic received a pancreas-spleen transplant from a group 0 donor. Severe immune hemolysis due to anti-A ensued, requiring graft splenectomy. The transplanted spleen can be a potent source of blood group antibody. ...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1985.tb00187.x
更新日期:1985-01-01 00:00:00
abstract::A pilot study for large-scale automated plasmapheresis using the Haemonetics Model 50 machine was undertaken in the Yorkshire Region of the United Kingdom to determine the viability of such a programme for national self-sufficiency in fresh plasma procurement for factor VIII concentrate production. The study was desig...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1983.tb01876.x
更新日期:1983-03-01 00:00:00
abstract::A patient with Guillain-Barré syndrome was successfully treated by plasma exchange (without any other therapy), and the relationship between changes in his peripheral blood lymphocyte subpopulations and the clinical improvement induced by plasma-pheresis was studied. At the recovery, the most interesting findings were...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1982.tb01103.x
更新日期:1982-01-01 00:00:00
abstract::The panagglutination phenomenon described by Thomsen and Friedenreich (TF) is due to the reaction of naturally occurring TF-antibodies with the carbohydrate group beta-D-Gal-(1-3)-D-GalNAc of desialylated glycophorin A, the major glycoprotein component of the erythrocyte membrane. The specificity of human TF-antibodie...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1985.tb00179.x
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:In order to describe the progression of HIV disease in a cohort of Dutch HIV-1-infected patients with haemophilia and to study the influence of clinical and clotting factors, we performed a 15-year longitudinal clinical and laboratory study. METHODS:The progression to AIDS in relation to type of haemophilia,...
journal_title:Vox sanguinis
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::A non-blow-molded LE-2 polyolefin (PO) container was developed to store single-donor apheresis platelet concentrates (PCs) processed by the Haemonetics Plasma Collecting System (PCS) at 22 degrees C for over 1 day. We molded PO containers with heat-sealing of light-weight polymer alloy films with a thickness of 0.25 m...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1989.tb02022.x
更新日期:1989-01-01 00:00:00
abstract::Detailed serological investigation of five examples of anti-Jka revealed considerable heterogeneity in their characteristics. All the sera were investigated by the antiglobulin technique, with and without complement and by a range of sensitization and testing methods. Three were readily detected in the presence of com...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1983.tb01897.x
更新日期:1983-01-01 00:00:00
abstract::A mouse IgG1 monoclonal antibody (MAb) UMRh, was prepared by immunizing Balb/c mice with the Jurkat T cell acute lymphoblastic leukemia (T-ALL) cell line. The MAb UMRh is directed against a widely distributed Rh-related cell surface antigen, present on red blood cells (RBCs) expressing the more common Rh phenotypes. T...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1993.tb03061.x
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The Blood Services of the UK permanently de-select men who have had sex with men (MSM) from donating blood. The rationale for this has been questioned. This article attempts to evaluate whether this selection criterion does contribute to blood safety. MATERIALS AND METHODS:Data about transfus...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1046/j.1423-0410.2003.00295.x
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The low prevalence antigen, Be(a), is produced by a complex that also produces weak c, e and f (ce). We report here the molecular basis associated with Be(a) antigen expression. MATERIALS AND METHODS:Peripheral blood samples from four Be(a+) probands were tested. Haemagglutination, gDNA extra...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.2009.01277.x
更新日期:2010-04-01 00:00:00
abstract::Blood transfusions are associated with clinical phenomena which are attributable to immune suppression. Since suppression of immune function is associated with a high risk of spontaneous malignancies, we studied T cell subsets and natural killer (NK) cytotoxicity in colorectal cancer patients and correlated the result...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.1989.tb04954.x
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Antibodies to antigens in the Kell blood group system, especially anti-KEL1, are involved in both haemolytic disease of the newborn and foetus and haemolytic transfusion reactions. Correct typing results are important and discrepancies between serologic and genetic typing must be resolved. Her...
journal_title:Vox sanguinis
pub_type: 杂志文章
doi:10.1111/j.1423-0410.2010.01334.x
更新日期:2010-08-01 00:00:00
abstract::The development of tests for variant Creutzfeldt-Jakob disease in the context of blood transfusion is technically complicated by a number of factors, including the long asymptomatic period and uncertainty as to whether infectivity is present in human blood at all. The specific needs of a donor test impose constraints....
journal_title:Vox sanguinis
pub_type: 杂志文章,评审
doi:10.1111/j.0042-9007.2004.00411.x
更新日期:2004-04-01 00:00:00