Abstract:
:63 Rh-negative male volunteers were immunized with D-positive red cells. 28 (44%) produced anti-D. To provide sustained levels of high concentration of anti-D, 18 of the 28 male volunteers have received repeated antigenic stimuli at individual intervals of 2-9 months. In all but 1 case the level of anti-D rose to between 30 and 300 microgram/ml and persisted at this level for several years. There was no evidence of a decrease in antibody response with an increase in the number of stimuli. 24 Rh-negative women immunized by pregnancy were restimulated. 16 achieved anti-D concentrations over 21 microgram/ml. The levels achieved were not influenced by the different D-positive cells injected, nor were larger antigenic doses of any benefit. No untoward clinical reactions occurred as a result of the repeated injections of antigenic material or of long-term plasmapheresis. 2 volunteers developed unwanted antibodies outside the Rh-system. Beginning in 1968, the programme to obtain anti-D plasma has yielded more than 70,000 doses of 250 microgram each, permitting the treatment of all Rh-negative women at risk.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Eklund Jdoi
10.1111/j.1423-0410.1978.tb02953.xsubject
Has Abstractpub_date
1978-01-01 00:00:00pages
387-96issue
6eissn
0042-9007issn
1423-0410journal_volume
35pub_type
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