Abstract:
:Inhibitor development represents the main complication in the treatment of haemophilia A. The risk of inhibitor formation is in part genetically determined by the type of the underlying factor VIII gene lesion but environmental factors may also play an important role. Due to the lack of efficiency of factor VIII in these patients other therapeutic agents must be used for the treatment of bleedings, however, none is as effective as factor VIII in a non-inhibitor patient. Therefore, the eridication of the inhibitor through immune tolerance therapy is the treatment of choice. Centralized national and international immune tolerance registries have collected the results and show cost effectiveness of this treatment.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Brackmann HH,Schwaab R,Effenberger W,Hess L,Hanfland P,Oldenburg Jsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
187-90eissn
0042-9007issn
1423-0410journal_volume
78 Suppl 2pub_type
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