Antibodies to factor VIII in hemophilia A patients.

Abstract:

:Inhibitor development represents the main complication in the treatment of haemophilia A. The risk of inhibitor formation is in part genetically determined by the type of the underlying factor VIII gene lesion but environmental factors may also play an important role. Due to the lack of efficiency of factor VIII in these patients other therapeutic agents must be used for the treatment of bleedings, however, none is as effective as factor VIII in a non-inhibitor patient. Therefore, the eridication of the inhibitor through immune tolerance therapy is the treatment of choice. Centralized national and international immune tolerance registries have collected the results and show cost effectiveness of this treatment.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Brackmann HH,Schwaab R,Effenberger W,Hess L,Hanfland P,Oldenburg J

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

187-90

eissn

0042-9007

issn

1423-0410

journal_volume

78 Suppl 2

pub_type

杂志文章,评审
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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1990.tb00853.x

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  • Antenatal blood group serology in Sudanese women.

    abstract::2,140 pregnant Sudanese women attending the antenatal clinic in Omdurman Maternity Hospital during the period November 1975 to December 1976 had ABO and Rh typing performed. Their sera were also screened by a modified papain enzyme technique for the presence of atypical antibodies. The rate of Rhesus immunization, the...

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    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1978.tb02889.x

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    更新日期:1978-01-01 00:00:00

  • Where and when is blood transfused? An observational study of the timing and location of red cell transfusions in the north of England.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章,评审

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