Splenic lymphoma presenting as warm autoimmune hemolytic anemia associated with pure red cell aplasia.

Abstract:

BACKGROUND AND OBJECTIVE:Warm autoimmune hemolytic anemia (AIHA) is a condition in which peripheral red blood cell (RBC) destruction is induced by the presence of an autoantibody. Pure red cell aplasia (PRCA) represents an isolated process of decreased erythropoiesis. The combination of both is quite rare, with a very poor prognosis. We describe a patient with isolated splenic lymphoma whose presentation was a combination of AIHA and PRCA. The patient was resistant to all treatment. MATERIALS AND METHODS:Erythroid colony assays were performed, in order to compare the effect of the patient's serum on colonies with that of a normal control. RESULTS:The patient's serum significantly suppressed normal erythroid colony growth. A red cell eluate revealed the presence of a warm autoantibody. CONCLUSIONS:The patient's serum contained warm autoantibody responsible for peripheral RBC destruction and a humoral factor, perhaps the warm autoantibody, which suppressed bone marrow erythropoiesis. Establishing an early diagnosis, and treatment of the underlying disease might result in a better prognosis.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Zeidman A,Fradin Z,Barac Y,Bendayan D,Mittelman M,Orlin J

doi

10.1159/000031163

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

126-9

issue

2

eissn

0042-9007

issn

1423-0410

pii

31163

journal_volume

78

pub_type

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