Abstract:
BACKGROUND AND OBJECTIVE:Warm autoimmune hemolytic anemia (AIHA) is a condition in which peripheral red blood cell (RBC) destruction is induced by the presence of an autoantibody. Pure red cell aplasia (PRCA) represents an isolated process of decreased erythropoiesis. The combination of both is quite rare, with a very poor prognosis. We describe a patient with isolated splenic lymphoma whose presentation was a combination of AIHA and PRCA. The patient was resistant to all treatment. MATERIALS AND METHODS:Erythroid colony assays were performed, in order to compare the effect of the patient's serum on colonies with that of a normal control. RESULTS:The patient's serum significantly suppressed normal erythroid colony growth. A red cell eluate revealed the presence of a warm autoantibody. CONCLUSIONS:The patient's serum contained warm autoantibody responsible for peripheral RBC destruction and a humoral factor, perhaps the warm autoantibody, which suppressed bone marrow erythropoiesis. Establishing an early diagnosis, and treatment of the underlying disease might result in a better prognosis.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Zeidman A,Fradin Z,Barac Y,Bendayan D,Mittelman M,Orlin Jdoi
10.1159/000031163subject
Has Abstractpub_date
2000-01-01 00:00:00pages
126-9issue
2eissn
0042-9007issn
1423-0410pii
31163journal_volume
78pub_type
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