Abstract:
:We developed a photodynamic method to inactivate viruses in human fresh plasma. Single plasma bags were illuminated with visible light in the presence of low doses of phenothiazine dyes like methylene blue or toluidine blue. By this treatment the infectivity of different enveloped viruses including the causative agent of AIDS, HIV-1, was completely removable from the plasma. Non enveloped viruses, however, proved to be more stable. The activities of clotting factors and other plasma proteins were only slightly decreased. There was no indication that the procedure led to important structural modifications of plasma proteins. The dyes are photodynamically active at concentrations much lower than those at which they are therapeutically used as antidots in the treatment of methemoglobinemia.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Lambrecht B,Mohr H,Knüver-Hopf J,Schmitt Hdoi
10.1111/j.1423-0410.1991.tb00907.xsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
207-13issue
4eissn
0042-9007issn
1423-0410journal_volume
60pub_type
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