Functional antibacterial activity of a human intravenous immunoglobulin preparation: in vitro and in vivo studies.

Abstract:

:The functional antibacterial activity of an intravenous immunoglobulin preparation (Swiss Red Cross Immunoglobulin, SRK-Ig) was tested both in vitro and in vivo. Using type III group B streptococci as a model system, the intravenous immunoglobulin preparation was shown to enhance phagocytosis and killing of the bacteria by human neutrophils. There was good activity to several type III strains, and for efficient opsonization both antibody and complement were required. In an animal model of neonatal group B streptococcal sepsis, passively administered immunoglobulin enhanced survival with 27/37 (73%) treated animals surviving compared to only 3/16 (19%) controls. These studies demonstrate that the intravenous immunoglobulin preparation SRK-Ig has retained functional activity and may have potential value for prophylaxis or therapy of certain bacteria infections.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Fischer GW,Hunter KW,Hemming VG,Wilson SR

doi

10.1111/j.1423-0410.1983.tb04485.x

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

296-9

issue

5

eissn

0042-9007

issn

1423-0410

journal_volume

44

pub_type

杂志文章
  • A family demonstrating inheritance of the Leach phenotype: a Gerbich-negative phenotype associated with elliptocytosis.

    abstract::The proposita of a Canadian family and 2 of her sibs have the rare Leach phenotype and provide the first evidence that the Leach phenotype is an inherited condition. Their red cells are Ge: -2, -3 and fail to react, by the antiglobulin test, with the monoclonal antibodies GERO, BRIC 4 and BRIC 10. The minor sialoglyco...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb04860.x

    authors: Daniels GL,Shaw MA,Judson PA,Reid ME,Anstee DJ,Colpitts P,Cornwall S,Moore BP,Lee S

    更新日期:1986-01-01 00:00:00

  • Inactivation of hepatitis A virus by pasteurization and elimination of picornaviruses during manufacture of factor VIII concentrate.

    abstract::Hepatitis A virus (HAV) infections have been reported among hemophiliacs who received factor VIII concentrates which had been purified by ion-exchange chromatography and treated by the solvent detergent (SD) method. Since the virus inactivation procedure of our manufacturing process is heat treatment of the stabilized...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: Hilfenhaus J,Nowak T

    更新日期:1994-01-01 00:00:00

  • Inefficacy of plasma exchange in cold agglutinin hemolytic anemia--a case study.

    abstract::A therapeutic trial of plasma exchange was conducted in an 82-year-old woman with severe cold agglutinin hemolytic anemia, who was unresponsive to conventional treatment. In spite of considerable improvement of pertinent parameters (total IgM, cold agglutinin titer and thermal amplitude) this treatment failed to induc...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00763.x

    authors: Rodenhuis S,Maas A,Hazenberg CA,Das PC,Nieweg HO

    更新日期:1985-01-01 00:00:00

  • Editorial: Red cell ageing and death.

    abstract::To obtain red cell populations of increasing mean age erythropoiesis was arrested through continuous actinomycin treatment or maintained transfusion polycythemia in mice and rats respectively. The parameters studied included cell indices, enzyme activities and rheological characteristics. Further, the life-span of age...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb02809.x

    authors: Ganzoni AM,Barras JP,Marti HR

    更新日期:1976-01-01 00:00:00

  • BS II lectin: a second hemagglutinin isolated from Bandeiraea simplicifolia seeds with affinity for type III polyagglutinable red cells.

    abstract::BS II lectin, a second hemagglutinin isolated from Bandeiraea simplicifolia seeds, agglutinated the red cells from 11 patients manifesting the 'acquired B' antigen phenomenon. The results of serological studies indicate that this lectin has specificity for the type III polyagglutinable receptors rather than for the 'B...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1977.tb04469.x

    authors: Judd WJ,Beck ML,Hicklin BL,Iyer PN,Goldstein IJ

    更新日期:1977-10-01 00:00:00

  • Results of a multicentre clinical trial of the solid-phase enzyme immunoassay for hepatitis B surface antigen.

    abstract::The results obtained in a multicentre clinical trial of an enzyme immunoassay (EIA) method for hepatitis B surface antigen (HBsAg) (65,451 sera tested) have demonstrated that this new test has a significantly higher sensitivity than a reversed haemagglutination test (rHA). In a part of the trial, EIA was also compared...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1978.tb02902.x

    authors: Kacaki J,Wolters G,Kuijpers L,Stulemeyer S

    更新日期:1978-07-01 00:00:00

  • Characterization of plasma protein activity in riboflavin and UV light-treated fresh frozen plasma during 2 years of storage at -30 degrees C.

    abstract:BACKGROUND:The Mirasol Pathogen Reduction Technology System (PRT) for Plasma (CaridianBCT) is based on a riboflavin and UV light treatment process resulting in pathogen inactivation due to irreversible, photochemically induced damage of nucleic acids. This study evaluated the in vitro protein quality of plasma products...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2009.01238.x

    authors: Bihm DJ,Ettinger A,Buytaert-Hoefen KA,Hendrix BK,Maldonado-Codina G,Rock G,Giclas PC,Goodrich RP

    更新日期:2010-02-01 00:00:00

  • Monitoring bacterial contamination of blood components in Germany: effect of contamination reduction measures.

    abstract:BACKGROUND AND OBJECTIVES:National guidelines for monitoring bacterial contamination of blood components were introduced in Germany in 1997. Between 1998 and 2002, numerous measures were implemented to prevent bacterial contamination. This study investigates their impact on contamination rates. MATERIALS AND METHODS:C...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2010.01432.x

    authors: Walther-Wenke G,Wirsing von König CH,Däubener W,Heiden M,Hoch J,Hornei B,Volkers P,Working Party on Bacteria Safety in Transfusion Medicine, Advisory Board of the German Ministry of Health, Berlin.

    更新日期:2011-05-01 00:00:00

  • Immunochemical characterization of the Rh CW antigen using human monoclonal antibodies.

    abstract:BACKGROUND AND OBJECTIVES:Human monoclonal antibodies have been produced against various Rh antigens. We report here the production of another one against Rh C and the first such antibody against Rh CW. MATERIALS AND METHODS:Two heterohybridomas secreting IgG human monoclonal antibodies against Rh CW and Rh C (MS-353 ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1997.7330174.x

    authors: Thorpe SJ,Boult CE,Thompson KM

    更新日期:1997-01-01 00:00:00

  • In vitro phagocytosis of liquid-stored red blood cells requires serum and can be inhibited with fucoidan and dextran sulphate.

    abstract:BACKGROUND AND OBJECTIVES:Red-blood-cells (RBCs) undergo structural and metabolic changes with prolonged storage, which ultimately may decrease their survival after transfusion. Although the storage-induced damage to RBCs has been rather well described biochemically, little is known about the mechanisms underlying the ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12922

    authors: Hult A,Toss F,Malm C,Oldenborg PA

    更新日期:2020-11-01 00:00:00

  • Prothrombin complex concentrates for clinical use.

    abstract::Prothrombin complex concentrates prepared for clinical use are reviewed with emphasis on frequently observed adverse reactions such as viral hepatitis and thromboembolic complications. Preparation procedures and quality control are described briefly, and the use of these concentrates in the treatment of hemophilia A p...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1981.tb01048.x

    authors: Chandra S,Brummelhuis HG

    更新日期:1981-11-01 00:00:00

  • Autologous platelet-rich plasma isolated using the Haemonetics Cell Saver 5 and Haemonetics MCS+ for the preparation of platelet gel.

    abstract:BACKGROUND AND OBJECTIVES:We compared three methods of isolating platelet-rich plasma (PRP) using the Haemonetics Cell Saver 5 and one method of isolating PRP by plateletpheresis using the Haemonetics MCS+. PRP contains both platelets and fibrinogen, which are used in the preparation of haemostatic agents. MATERIALS A...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2001.00099.x

    authors: O'Neill EM,Zalewski WM,Eaton LJ,Popovsky MA,Pivacek LE,Ragno G,Valeri CR

    更新日期:2001-10-01 00:00:00

  • Errors in interpreting the pretransfusion bedside compatibility test: an experimental study.

    abstract:BACKGROUND AND OBJECTIVE:Analysis of reports of incidents, involving ABO incompatibility suggests that the main problem is poor interpretation of the pretransfusion bedside compatibility test (PBCT). We studied sources of error as experienced by nurses as to the blood groups of donor blood and of the recipient. MATERI...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1159/000031147

    authors: Dujardin PP,Salmi LR,Ingrand P

    更新日期:2000-01-01 00:00:00

  • Mouse monoclonal anti-HBs and its use in the screening of donated blood by Elisa.

    abstract::A method is described for the production of mouse monoclonal antibodies to HBsAg. 4 clones produced antibodies directed at the a and one at the d determinant of HBsAg. These antibodies were conjugated to horse radish peroxidase and used in an Elisa for the detection of HBsAg in donated blood. Antibody C10 produced con...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb00070.x

    authors: Els MC,Govender M,Marimuthu T,Bubb MO,Conradie JD

    更新日期:1984-01-01 00:00:00

  • Re-evaluating the residual risk of transfusion-transmitted Ross River virus infection.

    abstract:BACKGROUND AND OBJECTIVES:Ross River virus (RRV) is an enveloped, RNA alphavirus in the same antigenic group as chikungunya virus. Australia records an annual average of 5000 laboratory-confirmed RRV infections. While RRV is currently geographically restricted to the Western Pacific, the capacity of arboviruses for rap...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12372

    authors: Seed CR,Hoad VC,Faddy HM,Kiely P,Keller AJ,Pink J

    更新日期:2016-05-01 00:00:00

  • Immunological monitoring of a patient with Guillain-Barré syndrome successfully treated with plasma exchange.

    abstract::A patient with Guillain-Barré syndrome was successfully treated by plasma exchange (without any other therapy), and the relationship between changes in his peripheral blood lymphocyte subpopulations and the clinical improvement induced by plasma-pheresis was studied. At the recovery, the most interesting findings were...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1982.tb01103.x

    authors: Fiorini G,Bigi G,Paracchini ML,Marinig C,Gibelli A

    更新日期:1982-01-01 00:00:00

  • Expression of genetic markers of erythrocyte immunoglobulin G autoantibodies in autoimmune hemolytic anemia.

    abstract::The Gm allotype constitution of the autoantibody molecules and the serum Gm phenotypes were determined in 19 patients with autiommune hemolytic anemia of IgG type. The results showed that the known heterogeneity of the antierythrocyte autoantibodies in this disease concerns not only the immunoglobulin class and the is...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb02208.x

    authors: Le Petit JC,Rivat L,François N,Ropartz C,Brizard CP

    更新日期:1976-01-01 00:00:00

  • Novel polymorphisms in exons 6 and 7 of A/B alleles detected by polymerase chain reaction-single strand conformation polymorphism.

    abstract:BACKGROUND AND OBJECTIVES:The ABO blood group system is the most important blood group system in transfusion medicine. In addition to the major A, B and O alleles, many rare alleles have been defined. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and analysis by PCR sequence specific pri...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2005.00729.x

    authors: Chen YJ,Chen PS,Liu HM,Lyou JY,Hu HY,Lin JS,Tzeng CH

    更新日期:2006-02-01 00:00:00

  • Blood group ABH antigens on human cord red cells. Number of H antigenic sites and their distribution among different classes of membrane constituents.

    abstract::When the blood group H sites of cord erythrocytes obtained from newborn infants of groups O, A, B and AB were labelled specifically by incubation of the whole cells with the A1 gene dependent alpha-N-acetylgalactosaminyl transferase in the presence of UDP-N-acetyl [14C]-galactosamine, the incorporation of radioactivit...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1980.tb04497.x

    authors: Schenkel-Brunner H

    更新日期:1980-06-01 00:00:00

  • In vivo behaviour of gamma globulin preparations.

    abstract::Metabolic properties of standard gamma globulin (St-GG) and of several gamma globulin (GG) preparations for intravenous use were analyzed in radioactive tracer studies. The in vivo behaviour of St-GG was investigated in 16 probands and found to be comparable to that of normal IgG. The kinetics of the resorption of St-...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1980.tb02367.x

    authors: Morell A,Schürch B,Ryser D,Hofer F,Skvaril F,Barandun S

    更新日期:1980-01-01 00:00:00

  • Analbuminemia: report of a case and review of the literature.

    abstract::Idiopathic analbuminemia was fortuitously detected in a 30-year-old Italian woman. No associated disease condition could be revealed in this patient, the only consistent finding being a slight tendency to develop ankle edema. Asthenia and a moderate hypotension were also recorded. Trace amounts (5.2 mg/100 ml) of seru...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1980.tb01851.x

    authors: Dammacco F,Miglietta A,D'Addabbo A,Fratello A,Moschetta R,Bonomo L

    更新日期:1980-09-01 00:00:00

  • A new solid phase radioimmunoassay (CLB-RIA) for the detection of hepatitis-B antigen and antibody.

    abstract::A new competitive solid phase radioimmunoassay (CLB-RIA) has been developed for the detection of HBAg and HBAb in human serum and plasma. In the assay, sheep antibodies to HBAg, covalently linked to an insoluble carrier, highly purified 125-I labelled HBAg and the serum or plasma sample are incubated for 20 h at room ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1975.tb00472.x

    authors: Duimel WJ,Brummelhuis HG

    更新日期:1975-01-01 00:00:00

  • Prospective evaluation of immune haemolysis in liver transplantation.

    abstract:BACKGROUND:Immune haemolysis in liver transplant (LT) can occur due to autoantibodies and alloantibodies. The aim of this study was to evaluate the prevalence and risk factors for immune haemolysis in LT. METHODS:A total of 175 consecutive patients were included. Multiorgan recipients were excluded. Samples, from befo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12865

    authors: Brunetta DM,de Barros Carlos LM,Da Silva VFP,de Oliveira Alves TM,Macedo ÊS,Coelho GR,Vasconcelos JBM,De Francesco Daher E,Garcia JHP

    更新日期:2020-01-01 00:00:00

  • Influence of granulocyte antibodies on granulocyte function.

    abstract::The following substances were tested for their influence on granulocyte function: 8 sera that contained human granulocyte-specific alloantibodies against the antigens NA1, NA2 and NB1, two HLA antisera, and the monoclonal antibodies W6/32 and CLB-FcR-gran 1. The effects examined included spontaneous and directed migra...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1993.tb03059.x

    authors: Bux J,Dickmann JO,Stockert U,Mueller-Eckhardt C

    更新日期:1993-01-01 00:00:00

  • Severe thrombocytopenia due to host-derived anti-HPA-1a after non-myeloablative allogeneic haematopoietic stem cell transplantation for multiple myeloma: a case report.

    abstract:BACKGROUND AND OBJECTIVES:Host- or donor-derived alloimmune thrombocytopenia can develop after non-myeloablative allogeneic haematopoietic stem cell transplantation (HSCT). We report the first case of host-derived HPA-1a antibodies. CASE REPORT:A 52-year-old male patient received HSCT from his human leucocyte antigen ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2005.00692.x

    authors: Macher S,Schallmoser K,Staber PB,Neumeister P,Posch U,Lanzer G,Panzer S

    更新日期:2005-11-01 00:00:00

  • Isoagglutinins following ABO-incompatible bone marrow transplantation.

    abstract::Isoagglutinins were investigated following ABO-incompatible bone marrow transplantation. In major incompatibility anti-A tends to require more time to disappear than anti-B. Correspondingly, A erythrocytes require more time to become demonstrable. There is no such difference in major plus minor incompatibility. In min...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1992.tb01194.x

    authors: Wernet D,Mayer G

    更新日期:1992-01-01 00:00:00

  • Mimicking anti-S simulating a delayed transfusion reaction.

    abstract::An autoantibody mimicking anti-S specificity is described in an S-s+ patient. The antibody was detected 2 weeks after transfusion. The direct antiglobulin test (DAT) was positive and the antibody was thought to be an alloantibody formed after the transfusion. Eighteen months later, the DAT was still positive and anti-...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1987.tb04944.x

    authors: Puig N,Carbonell F,Soler MA,Perez MT,Arriaga F,Marty ML

    更新日期:1987-01-01 00:00:00

  • White-blood-cell-containing allogeneic blood transfusion, postoperative infection and mortality: a meta-analysis of observational 'before-and-after' studies.

    abstract:BACKGROUND AND OBJECTIVES:An association of white blood cell (WBC) reduction with decreased mortality was reported by one observational, before-and-after study. A meta-analysis was undertaken to examine whether this finding is supported by all the evidence currently available from before-and-after studies, and whether ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.0042-9007.2004.00394.x

    authors: Vamvakas EC

    更新日期:2004-02-01 00:00:00

  • The effects of leg crossing and applied tension on blood donor return.

    abstract:BACKGROUND AND OBJECTIVES:Repeated isometric muscle tension (applied tension) during blood donation reduces vasovagal symptoms in many donors. Experiencing vasovagal symptoms has been found to reduce blood donor return. However, does practicing applied tension improve blood donor return? Follow-up results from a random...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/vox.12055

    authors: Ditto B,Gilchrist PT,Holly CD,Dubuc S,Delage G,France CR

    更新日期:2013-11-01 00:00:00

  • Technical aspects of the development and validation of tests for variant Creutzfeldt-Jakob disease in blood transfusion.

    abstract::The development of tests for variant Creutzfeldt-Jakob disease in the context of blood transfusion is technically complicated by a number of factors, including the long asymptomatic period and uncertainty as to whether infectivity is present in human blood at all. The specific needs of a donor test impose constraints....

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.0042-9007.2004.00411.x

    authors: Minor PD

    更新日期:2004-04-01 00:00:00