Abstract:
:The proposita of a Canadian family and 2 of her sibs have the rare Leach phenotype and provide the first evidence that the Leach phenotype is an inherited condition. Their red cells are Ge: -2, -3 and fail to react, by the antiglobulin test, with the monoclonal antibodies GERO, BRIC 4 and BRIC 10. The minor sialoglycoproteins beta, beta 1 and gamma are apparently absent from their red cell membranes. A proportion of their red cells are elliptocytes indicating that beta and/or beta 1 and/or gamma have a function in maintaining normal red cell shape.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Daniels GL,Shaw MA,Judson PA,Reid ME,Anstee DJ,Colpitts P,Cornwall S,Moore BP,Lee Sdoi
10.1111/j.1423-0410.1986.tb04860.xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
117-121issue
2eissn
0042-9007issn
1423-0410journal_volume
50pub_type
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