A family demonstrating inheritance of the Leach phenotype: a Gerbich-negative phenotype associated with elliptocytosis.

Abstract:

:The proposita of a Canadian family and 2 of her sibs have the rare Leach phenotype and provide the first evidence that the Leach phenotype is an inherited condition. Their red cells are Ge: -2, -3 and fail to react, by the antiglobulin test, with the monoclonal antibodies GERO, BRIC 4 and BRIC 10. The minor sialoglycoproteins beta, beta 1 and gamma are apparently absent from their red cell membranes. A proportion of their red cells are elliptocytes indicating that beta and/or beta 1 and/or gamma have a function in maintaining normal red cell shape.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Daniels GL,Shaw MA,Judson PA,Reid ME,Anstee DJ,Colpitts P,Cornwall S,Moore BP,Lee S

doi

10.1111/j.1423-0410.1986.tb04860.x

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

117-121

issue

2

eissn

0042-9007

issn

1423-0410

journal_volume

50

pub_type

杂志文章
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