A comparison of in vitro tests for predicting the severity of haemolytic disease of the fetus and newborn.

Abstract:

:Haemolytic disease of the newborn (HDN) is characterized by the presence of IgG antibodies in the maternal circulation which cause haemolysis in the fetus by crossing the placenta and sensitizing red cells for destruction by macrophages in the fetal spleen. Numerous serological, quantitative and cellular assays have been developed to predict the severity of HDN. These assays all measure and/or characterize alloantibodies in the maternal circulation. Quantitative assays which accurately measure antibody levels correlate with disease severity better than serological assays which are inherently less precise. Nevertheless, high antibody levels are found in some cases of mild HDN and relatively low antibody levels are found in some severe cases. This suggests that disease severity is influenced by factors in addition to antibody concentration. These factors remain to be fully elucidated but may include the subclass and glycosylation of maternal antibodies, the structure, site density, maturational development and tissue distribution of blood group antigens, the efficiency of IgG transport to the fetus, the functional maturity of the fetal spleen, polymorphisms which affect Fc receptor function, and the presence of HLA-related inhibitory antibodies. Cellular assays which are sensitive to factors affecting antibody function have therefore been developed in an attempt to improve the prediction of disease severity. Although these assays are cumbersome, there are now sufficient data to suggest that some cellular assays, when used as part of a structured approach to diagnostic testing, may provide clinically-useful information to complement serological and quantitative assays.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Hadley AG

doi

10.1111/j.1423-0410.1998.tb05445.x

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

375-83

eissn

0042-9007

issn

1423-0410

journal_volume

74 Suppl 2

pub_type

杂志文章,评审
  • Removal of hepatitis B virus infectivity from human gamma-globulin prepared by ion-exchange chromatography.

    abstract::Hepatitis B virus infectivity can be removed from human plasma used to prepare a gamma-globulin product by ion-exchange chromatography with commercially available resins. A pooled human plasma sample free of hepatitis markers was contaminated with 10,000 chimpanzee infectious doses of hepatitis B virus per milliliter ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb01130.x

    authors: Zolton RP,Padvelskis JV,Kaplan PM

    更新日期:1985-01-01 00:00:00

  • Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation.

    abstract:BACKGROUND AND OBJECTIVES:Red-blood-cell (RBC) transfusion is associated with lung injury, which is further exacerbated by mechanical ventilation. Manufacturing methods of blood products differ globally and may play a role in the induction of pulmonary cell activation through alteration of the immunomodulatory property...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12911

    authors: Wirtz MR,Almizraq RJ,Weber NC,Norris PJ,Pandey S,Spinella PC,Muszynski JA,P Acker J,Juffermans NP

    更新日期:2020-07-01 00:00:00

  • Platelet transfusions in haematologic malignancies in the last six months of life.

    abstract:BACKGROUND AND OBJECTIVES:Practices in end-of-life platelet transfusions in haematologic malignancies are variable. Our aim was to describe the platelet transfusion burden and parameters linked to this indication in such a setting and thereby contribute to defining optimal practices. MATERIALS AND METHODS:From July 20...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12986

    authors: Moracchini J,Seigeot A,Angelot-Delettre F,Vienot A,Aubry R,Daguindau É,Deconinck E,Frache S,Tiberghien P

    更新日期:2020-08-13 00:00:00

  • Alanine aminotransferase, gamma-glutamyltransferase, antibodies to hepatitis B core antigen and antibodies to hepatitis C virus in blood donor screening. A prospective study in Finland.

    abstract::Alanine aminotransferase (ALT), gamma-glutamyl-transferase and hepatitis B core antibodies were evaluated as donor markers in a prospective study of 685 open-heart surgery patients. Of these three surrogate markers, only an ALT level greater than or equal to 2 SD above the log mean had a significant association with r...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1991.tb00909.x

    authors: Ebeling F

    更新日期:1991-01-01 00:00:00

  • Characterization of plasma protein activity in riboflavin and UV light-treated fresh frozen plasma during 2 years of storage at -30 degrees C.

    abstract:BACKGROUND:The Mirasol Pathogen Reduction Technology System (PRT) for Plasma (CaridianBCT) is based on a riboflavin and UV light treatment process resulting in pathogen inactivation due to irreversible, photochemically induced damage of nucleic acids. This study evaluated the in vitro protein quality of plasma products...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2009.01238.x

    authors: Bihm DJ,Ettinger A,Buytaert-Hoefen KA,Hendrix BK,Maldonado-Codina G,Rock G,Giclas PC,Goodrich RP

    更新日期:2010-02-01 00:00:00

  • Metagenomics analysis of the virome of 300 concentrates from a Swiss platelet bank.

    abstract:BACKGROUND AND OBJECTIVES:Platelet concentrates are frequently transfused to patients with reduced immunity. An exhaustive description of their viral content is needed to prevent unwanted infection. MATERIAL AND METHODS:To track viral sequences, a shotgun metagenomics approach was used on a bank of 300 platelets conce...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12695

    authors: Brito F,Cordey S,Delwart E,Deng X,Tirefort D,Lemoine-Chaduc C,Zdobnov E,Lecompte T,Kaiser L,Waldvogel-Abramowski S,Preynat-Seauve O

    更新日期:2018-07-18 00:00:00

  • Reduced risk of transfusion-transmitted HIV in Kenya through centrally co-ordinated blood centres, stringent donor selection and effective p24 antigen-HIV antibody screening.

    abstract:BACKGROUND:Following a 1994 study showing a high rate of transfusion-associated HIV, Kenya implemented WHO blood safety recommendations including: organizing the Kenya National Blood Transfusion Service (NBTS), stringent blood donor selection, and universal screening with fourth-generation p24 antigen and HIV antibody ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2010.01340.x

    authors: Basavaraju SV,Mwangi J,Nyamongo J,Zeh C,Kimani D,Shiraishi RW,Madoda R,Okonji JA,Sugut W,Ongwae S,Pitman JP,Marum LH

    更新日期:2010-10-01 00:00:00

  • The D antigen characteristic of RoHar is a partial D antigen.

    abstract::The results of testing RoHarr cells with panels of monoclonal anti-D suggest that the D antigen (referred to as DHar) encoded by the haplotype (D)c(e) Rh33 is a partial D antigen. IgM monoclonal anti-D are more efficient than IgG monoclonal anti-D in detecting DHar.DHar expresses some but not all of both epD5 and epD6...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1996.tb01317.x

    authors: Wallace M,Lomas-Francis C,Tippett P

    更新日期:1996-01-01 00:00:00

  • Anti-granulocyte antibody screening with extracted granulocyte antigens by a micro-mixed passive hemagglutination method.

    abstract:BACKGROUND AND OBJECTIVES:Serologic tests for granulocyte antibodies, i.e., the granulocyte agglutination test and the granulocyte immunofluorescence test, require panels of typed granulocytes that cannot be preserved for more than a few hours. We have developed a new method in which granulocyte antigens, extracted int...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章

    doi:10.1159/000031073

    authors: Araki N,Nose Y,Kohsaki M,Mito H,Ito K

    更新日期:1999-01-01 00:00:00

  • Acquired B antigen, Tk activation and A1 destroying enzyme activity in a patient with septicaemia.

    abstract::During the course of septicaemia, a group A1 patient developed several RBC antigenic modifications. Acquired B antigen, Tk transformation and a partial disappearance of A1 receptors associated with an increase of H reactivity were observed. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1979.tb04426.x

    authors: Byrne V,Brown A,Ropars C,Moore BP

    更新日期:1979-01-01 00:00:00

  • Flow cytometry: a tool in immunohematology for D+W (Du) antigen evaluation?

    abstract::We performed a flow-cytometric analysis of the expression of D antigen in D+W samples (previously termed Du). We also analysed a series of D-positive and D-negative (cde phenotype) samples to obtain positive and negative controls, respectively. The evaluation was carried out by immunofluorescence and the intensity of ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1994.tb01278.x

    authors: Tazzari PL,Bontadini A,Belletti D,Malferrari F,Conte R

    更新日期:1994-01-01 00:00:00

  • In vivo recovery and survival of red cells after photodynamic treatment with thiopyrylium and red light using a canine model.

    abstract::Recently, we have shown that thiopyrylium has robust inactivation capabilities against a broad spectrum of pathogens in the human red blood cell (RBC) suspensions while retaining key RBC in vitro properties. The 24-h recovery and survival of canine red cells were measured upon autologus reinfusion of control and photo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2006.00864.x

    authors: Skripchenko A,Balch A,Mackin A,Wagner SJ

    更新日期:2007-02-01 00:00:00

  • Persistent aggregates in apheresis platelet concentrates.

    abstract:BACKGROUND:Aggregates often appear during apheresis. Sometimes, these persist throughout storage, causing product wastage. This study assessed product quality of apheresis concentrates containing persistent aggregates (PA) and aimed to identify the factors that contribute to their formation. METHODS:Donation (n = 180)...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12243

    authors: Feys HB,Coene J,Devloo R,Van Aelst B,Pottel H,Vandekerckhove P,Compernolle V

    更新日期:2015-05-01 00:00:00

  • Plasmodium falciparum malaria and the immunogenetics of ABO, HLA, and CD36 (platelet glycoprotein IV).

    abstract::Plasmodium falciparum malaria has long been a killer of the young, and has selected for polymorphisms affecting not only erythrocytes, but the immunogenetics of three histocompatibility systems: ABO, human leukocyte antigen (HLA), and CD36. The ABO system is important because the original allele, encoding glycosylatio...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.2010.01429.x

    authors: Cserti-Gazdewich CM,Mayr WR,Dzik WH

    更新日期:2011-01-01 00:00:00

  • Blood donors infected with the hepatitis B virus but persistently lacking antibodies to the hepatitis B core antigen.

    abstract:BACKGROUND AND OBJECTIVES:Antibodies to the core of hepatitis B virus (anti-HBc) are considered to be the best serologically reliable markers of hepatitis B virus (HBV) infection. Through a national epidemiological survey, two young and first-time blood donors, originating from HBV-endemic areas, were identified as HBV...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2001.00016.x

    authors: Laperche S,Guitton C,Smilovici W,Courouce AM

    更新日期:2001-02-01 00:00:00

  • What would encourage blood donation in Ireland?

    abstract:BACKGROUND:Recent changes have resulted in the loss of 4% of the donor panel in the Republic of Ireland and 3% in Northern Ireland. In order to increase the number of donors in these two regions, it is important that transfusion service providers explore and understand the reasons, which prevent individuals from donati...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2007.00893.x

    authors: Harrington M,Sweeney MR,Bailie K,Morris K,Kennedy A,Boilson A,O'Riordan J,Staines A

    更新日期:2007-05-01 00:00:00

  • World Health Organization collaborative study to calibrate the 3rd International Standard for Hepatitis C virus RNA nucleic acid amplification technology (NAT)-based assays.

    abstract:BACKGROUND AND OBJECTIVES:A collaborative study was undertaken to evaluate a replacement World Health Organization International Standard for hepatitis C virus (HCV) RNA for nucleic acid amplification technology (NAT)-based assays. The candidate preparations were calibrated in International Units (IUs). MATERIALS AND ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1423-0410.2010.01434.x

    authors: Baylis SA,Heath AB,Collaborative Study Group.

    更新日期:2011-05-01 00:00:00

  • A simplified method for the preparation of immune-serum globulin.

    abstract::This report describes the recovery of highly purified immune-serum globulin (ISG) from the 42% ethanol precipitate fraction (42% P) generated during the first step of albumin purification. The method consists of three purification steps: (1) reprecipitation of the 42% P at 20% ethanol, pH 7.2; (2) solubilization of IS...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1981.tb00706.x

    authors: Hao YL,Wickerhauser M

    更新日期:1981-04-01 00:00:00

  • Preparation of 131I-asialo-alpha1-acid glycoprotein.

    abstract::Alpha1-Acid glycoprotein (orosomucoid) was prepared from a byproduct of the ethanol plasma fractionation by means of ion-exchange procedures. Immunoelectrophoresis suggested a high degree of purity; the purified protein contained 13.5% sialic acid and 17.8% hexose. The alpha1-acid glycoprotein was modified by removal ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb02846.x

    authors: van Rijk PP,Heinsius HL,van den Hamer CJ

    更新日期:1976-01-01 00:00:00

  • Immunochemical characterization of the Rh CW antigen using human monoclonal antibodies.

    abstract:BACKGROUND AND OBJECTIVES:Human monoclonal antibodies have been produced against various Rh antigens. We report here the production of another one against Rh C and the first such antibody against Rh CW. MATERIALS AND METHODS:Two heterohybridomas secreting IgG human monoclonal antibodies against Rh CW and Rh C (MS-353 ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1997.7330174.x

    authors: Thorpe SJ,Boult CE,Thompson KM

    更新日期:1997-01-01 00:00:00

  • Diverse and novel RHD variants in Australian blood donors with a weak D phenotype: implication for transfusion management.

    abstract:BACKGROUND AND OBJECTIVES:Variant RHD genes associated with the weak D phenotype can result in complete or partial D-epitope expression on the red cell. This study examines the genetic classification in Australian blood donors with a weak D phenotype and correlates RHD variants associated with the weak D phenotype agai...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12488

    authors: McGowan EC,Lopez GH,Knauth CM,Liew YW,Condon JA,Ramadi L,Parsons K,Turner EM,Flower RL,Hyland CA

    更新日期:2017-04-01 00:00:00

  • Hepatitis E in transfusion-dependent thalassaemia patients, in Greece: a single centre experience.

    abstract::Hepatitis E is considered an emerging disease that may be a threat in both developing and industrialized countries all over the world. The risk of chronic hepatitis E virus infection is higher among immunocompromised patients. This study aimed to assess the status of hepatitis E infection in patients with transfusion-...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12572

    authors: Klonizakis P,Gioula G,Exindari M,Apostolou C,Kotsiafti A,Vlachaki E

    更新日期:2017-10-01 00:00:00

  • Intrapatient comparison of an intermittent and a continuous flow cell separator for the collection of progenitor and stem cells from the blood.

    abstract:BACKGROUND AND OBJECTIVES:Continuous-flow and intermittent-flow blood cell separators (CFCS and IFCS) are both used to collect stem cells from the blood to rescue patients undergoing myeloablative treatment for cancer. MATERIALS AND METHODS:We designed a study to compare the collection efficiency of the two systems. T...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: Beretta F,van den Bosch S,Castelli D,Cavalli F,Ghielmini M

    更新日期:1998-01-01 00:00:00

  • Cytokines in platelet concentrates prepared from pooled buffy coats.

    abstract::Platelet concentrates (PC) prepared from pooled buffy coat (BC-PC) contain a variable number of leukocytes from different donors. We questioned whether storage of BC-PC can lead to a lymphocyte activation in the sense of a mixed lymphocyte reaction. BC-PC were prepared from four ABO-identical buffy coats and we undert...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1995.tb00345.x

    authors: Klüter H,Müller-Steinhardt M,Danzer S,Wilhelm D,Kirchner H

    更新日期:1995-01-01 00:00:00

  • A family demonstrating inheritance of the Leach phenotype: a Gerbich-negative phenotype associated with elliptocytosis.

    abstract::The proposita of a Canadian family and 2 of her sibs have the rare Leach phenotype and provide the first evidence that the Leach phenotype is an inherited condition. Their red cells are Ge: -2, -3 and fail to react, by the antiglobulin test, with the monoclonal antibodies GERO, BRIC 4 and BRIC 10. The minor sialoglyco...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb04860.x

    authors: Daniels GL,Shaw MA,Judson PA,Reid ME,Anstee DJ,Colpitts P,Cornwall S,Moore BP,Lee S

    更新日期:1986-01-01 00:00:00

  • A new method for phenotyping red blood cells using microplates.

    abstract:BACKGROUND AND OBJECTIVES:The supply of phenotyped red blood cells (RBC) for patients with several RBC antibodies presents a difficult task to hospital blood banks and regional blood centers. The aim of this study was to establish a low-cost typing system to allow extensive phenotyping of regular blood donors for clini...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1159/000031093

    authors: Llopis F,Carbonell-Uberos F,Montero MC,Bonanad S,Planelles MD,Plasencia I,Riol C,Planells T,Carrillo C,De Miguel A

    更新日期:1999-01-01 00:00:00

  • Stability of coagulation factors in thawed, solvent/detergent-treated plasma during storage at 4 degrees C for 6 days.

    abstract:BACKGROUND AND OBJECTIVES:Transfusion of fresh-frozen plasma is still a pillar in emergency medicine for using to prevent dilutional coagulopathy or disseminated intravascular coagulation after severe blood loss, but thawing procedures can delay its availability. On the other hand, the wastage of plasma, once thawed an...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2004.00552.x

    authors: Buchta C,Felfernig M,Höcker P,Macher M,Körmöczi GF,Quehenberger P,Heinzl H,Knöbl P

    更新日期:2004-10-01 00:00:00

  • Effect of periodate oxidation on specific activities and carbohydrate components of human blood group N- and M-specific glycoproteins and glycopeptides.

    abstract::Mild as well as strong periodate oxidation of isolated erythrocyte N and M glycoproteins and glycopeptides gave extensive to complete destruction of N-specificities as measured with Vicia graminea extracts and of N- as well as M- activities determined with all but 1 of 8 animal anti-N and 13 anti-M sera. Results with ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1978.tb02931.x

    authors: Springer GF,Yang HJ

    更新日期:1978-01-01 00:00:00

  • Large-scale production and properties of immunoaffinity-purified human activated protein C concentrate.

    abstract::Activated protein C (APC) is a highly specific serine proteinase which functions as an important naturally occurring antithrombotic enzyme. APC also has anti-inflammatory properties. We have developed a large-scale process for the production of APC for therapeutic use starting with cryoprecipitate-poor human plasma. T...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1995.tb00366.x

    authors: Orthner CL,Ralston AH,Gee D,Kent R,Kolen B,McGriff JD,Drohan WN

    更新日期:1995-01-01 00:00:00

  • Red-blood-cell alloimmunization and female sex predict the presence of HLA antibodies in patients undergoing liver transplant.

    abstract:BACKGROUND:Refractoriness to platelet transfusion because of HLA antibodies can jeopardize the outcome of patients who require platelet support during surgery. As routine screening for HLA antibodies would pose a huge burden on presurgical work-ups, a stratification of patients according to the risk of having HLA antib...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2010.01347.x

    authors: Sanz C,Ghita G,Franquet C,Martínez I,Pereira A

    更新日期:2010-10-01 00:00:00