Removal of hepatitis B virus infectivity from human gamma-globulin prepared by ion-exchange chromatography.

Abstract:

:Hepatitis B virus infectivity can be removed from human plasma used to prepare a gamma-globulin product by ion-exchange chromatography with commercially available resins. A pooled human plasma sample free of hepatitis markers was contaminated with 10,000 chimpanzee infectious doses of hepatitis B virus per milliliter from a known infectious inoculum. The contaminated plasma was diluted to yield a weakly positive radioimmunoassay result for HBsAg and then processed over a double-column chromatography system containing anionic ion-exchange resins to yield highly purified gamma-globulin. Two chimpanzees were each inoculated intravenously with this product while a control animal received non-treated material. The 2 experimental animals each received a potential challenge of 3,000 ID and showed no serologic evidence of the disease during 9 months of evaluation. The control animal received 100 ID and developed hepatitis B 25 weeks after the challenge.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Zolton RP,Padvelskis JV,Kaplan PM

doi

10.1111/j.1423-0410.1985.tb01130.x

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

381-9

issue

6

eissn

0042-9007

issn

1423-0410

journal_volume

49

pub_type

杂志文章
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