Cytokines in platelet concentrates prepared from pooled buffy coats.

abstract：BACKGROUND:The platelet gel is made by embedding concentrate platelets within a semisolid (gel) network of polymerized fibrin. It is believed that this blood component will be used more and more in the treatment of several clinical conditions and as an adjunctive material in tissue engineering. Several systems are avai...

journal_title：Vox sanguinis

authors： Mazzucco L,Balbo V,Cattana E,Borzini P

更新日期：2008-04-01 00:00:00

abstract：:Sera obtained from 4 mothers of children with neonatal alloimmune thrombocytopenia contained a platelet-specific alloantibody, anti-Bra, which defined an antigen apparently different from all known platelet alloantigens. All 4 fathers were Bra positive, whereas all mothers were Bra negative. The minimal postnatal valu...

journal_title：Vox sanguinis

authors： Kiefel V,Santoso S,Katzmann B,Mueller-Eckhardt C

更新日期：1988-01-01 00:00:00

abstract：:In this prospective study, 26 consecutive patients being treated for haematological malignancies receiving standard (i.e. non-leucocyte-depleted) blood components were observed for the development of refractoriness to platelet transfusions. One hundred and sixteen of the 266 (44%) platelet transfusions failed to produ...

journal_title：Vox sanguinis

authors： Doughty HA,Murphy MF,Metcalfe P,Rohatiner AZ,Lister TA,Waters AH

更新日期：1994-01-01 00:00:00

abstract：:Employing standardized IgG-coated 51Cr-labelled human red blood cells (RBC), variation in rosette formation among monolayers obtained from 10 healthy donors was defined, as well as variation among 24 sequential monolayers obtained from one healthy donor and 8 sequential monolayers from a second healthy donor over a 4-...

journal_title：Vox sanguinis

authors： Munn LR,Chaplin H Jr

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Ross River virus (RRV) is an enveloped, RNA alphavirus in the same antigenic group as chikungunya virus. Australia records an annual average of 5000 laboratory-confirmed RRV infections. While RRV is currently geographically restricted to the Western Pacific, the capacity of arboviruses for rap...

journal_title：Vox sanguinis

authors： Seed CR,Hoad VC,Faddy HM,Kiely P,Keller AJ,Pink J

更新日期：2016-05-01 00:00:00

abstract：:Pst I endonuclease fragment length polymorphism of the antithrombin III probe was studied in a French population. Among 25 subjects tested, 15 were found heterozygous at the Pst I site, so that this polymorphism might serve as a useful markers of antithrombin III gene in families with antithrombin III deficiency. ...

journal_title：Vox sanguinis

authors： Le Paslier D,Rochu D,Lucotte G

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:White blood cell (WBC) fragments in platelet concentrates (PCs) may induce allo-immunization in the recipient. MATERIALS AND METHODS:As the level of WBC fragments can differ between PCs produced using different methods, we compared PCs prepared by using the buffy-coat method (BC-PCs) in plasm...

journal_title：Vox sanguinis

authors： Dijkstra-Tiekstra MJ,van der Schoot CE,Pietersz RN,Reesink HW

更新日期：2005-05-01 00:00:00

abstract：:Bacterial contamination of platelet concentrates poses a major post-transfusion infectious risk. This study was aimed at evaluating the efficacy of the BacTx(®) assay (Immunetics Inc.) for bacterial detection in leucocyte-reduced buffy coat platelet pools and for its sensitivity in detecting clinical isolates, includi...

journal_title：Vox sanguinis

authors： Ramirez-Arcos S,Kou Y,Perkins H

更新日期：2014-08-01 00:00:00

abstract：:Monocyte-erythrocyte interaction in patients with autoimmune haemolytic anaemia (AIHA) was assessed by phagocytosis and rosette assays. In most patients, a relationship was observed between haemolysis and the phagocytosis of their own erythrocytes by allogenic peripheral monocytes. An evaluation of the number of immun...

journal_title：Vox sanguinis

authors： Zupańska B,Brojer E,Thomson EE,Merry AH,Seyfried H

更新日期：1987-01-01 00:00:00

abstract：:The formation of mono(ethylhexyl)phthalate (MEHP) from di(ethylhexyl)phthalate in human plasma stored in bags of polyvinylchloride has been studied. Substantial amounts were formed and in ten bags from 4 to 56microgram/ml were found. After 2 weeks at room temperature the concentration of MEHP had increased to values b...

journal_title：Vox sanguinis

authors： Vessman J,Rietz G

更新日期：1978-07-01 00:00:00

abstract：:The results of the serological typing and the patterns of restriction fragment length polymorphisms for the detection of HLA-DR gene products are compared. The data shown demonstrate that the use of DNA typing gives a clearer definition of the HLA-DR antigens and that the HLA-DR polymorphism is greater than detected b...

journal_title：Vox sanguinis

authors： Nagy M,Mayr WR,Menzel GR

更新日期：1991-01-01 00:00:00

abstract：:Anti-D levels in blood taken immediately postpartum from Rh-negative women who have been given antenatal Rh immune globulin and the anti-D levels in the cord blood of their babies were measured semiquantitatively by a low ionic polybrene Auto Analyzer technique. When both mother and baby were Rh-negative a comparison ...

journal_title：Vox sanguinis

authors： Pollock JM,Bowman JM

更新日期：1982-01-01 00:00:00

abstract：:The functional antibacterial activity of an intravenous immunoglobulin preparation (Swiss Red Cross Immunoglobulin, SRK-Ig) was tested both in vitro and in vivo. Using type III group B streptococci as a model system, the intravenous immunoglobulin preparation was shown to enhance phagocytosis and killing of the bacter...

journal_title：Vox sanguinis

authors： Fischer GW,Hunter KW,Hemming VG,Wilson SR

更新日期：1983-01-01 00:00:00

abstract：:We performed a flow-cytometric analysis of the expression of D antigen in D+W samples (previously termed Du). We also analysed a series of D-positive and D-negative (cde phenotype) samples to obtain positive and negative controls, respectively. The evaluation was carried out by immunofluorescence and the intensity of ...

journal_title：Vox sanguinis

authors： Tazzari PL,Bontadini A,Belletti D,Malferrari F,Conte R

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Variant RHD genes associated with the weak D phenotype can result in complete or partial D-epitope expression on the red cell. This study examines the genetic classification in Australian blood donors with a weak D phenotype and correlates RHD variants associated with the weak D phenotype agai...

journal_title：Vox sanguinis

authors： McGowan EC,Lopez GH,Knauth CM,Liew YW,Condon JA,Ramadi L,Parsons K,Turner EM,Flower RL,Hyland CA

更新日期：2017-04-01 00:00:00

abstract：:We tested serum samples from 11 HIV-seropositive and 32 HIV-seronegative Italian patients with hemophilia A or B for the presence of lymphocytotoxic antibodies (LCTAs). No patients had the acquired immune deficiency syndrome and all had received over many years heat-untreated commercial clotting factors. LCTAs directe...

journal_title：Vox sanguinis

authors： Conte R,Giovanardi L,Tazzari PL,De Rosa V,Rodorigo G,Re MC

更新日期：1988-01-01 00:00:00

abstract：:A chromatographical study was made of eight antisera containing either anti-HL-A antibodies, cold lymphocytotoxins, or a mixture of both types of antibodies. The results vary according to the sera obtained. Usually cold lymphocytotoxins are sited in the IgM peak and anti-HL-A antibodies in the IgG peak, but there are ...

journal_title：Vox sanguinis

authors： Mayer S,Hauptmann G,Tongio MM

更新日期：1976-01-01 00:00:00

abstract：:Human IgG separated by Cohn fractionation showed variability in the content of aggregates, plasminogen and anticomplement activity. The plasminogen was removed or markedly reduced by affinity chromatography on Sepharose-lysine. Anticomplement activity was reduced by chromatography of Cohn fraction II on DEAE-cellulose...

journal_title：Vox sanguinis

authors： Habeeb AF,Francis RD

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transfusion support for immune-mediated platelet refractoriness (PR) is clinically challenging, technically laborious and costly. The development of 'EpHLA/EpVix software' has been used successfully to select kidney donors. Here, we sought to evaluate this new software as a tool for platelet v...

journal_title：Vox sanguinis

authors： Bub CB,Gonçalez AC,Barjas-Castro ML,Sousa LC,do Monte SJ,Castro V

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Polymorphonuclear neutrophils (PMNs) play important roles in the host immune defence. This study was performed to identify roles of PMNs other than those already known. MATERIALS AND METHODS:PMNs were separated from the peripheral blood of healthy individuals and stored in vitro for 24 h in t...

journal_title：Vox sanguinis

authors： Nishimura M,Mitsunaga S,Juji T

更新日期：2002-04-01 00:00:00

abstract：:A new therapeutic plasma exchange device developed by Sarns Inc./3M was evaluated in plasmapheresis of 20 healthy volunteers and in a multicenter clinical study of therapeutic plasma exchange that included 49 patients. Safety and efficacy of plasma separation from whole blood were assessed for a module that contains D...

journal_title：Vox sanguinis

authors： Kurtz SR,Carey PM,McGill M,Pineda AA,Zaroulis CG,Case MT

更新日期：1987-01-01 00:00:00

abstract：:The present report describes a technique for the production of monospecific rabbit antiserum to rat fibrinogen and its use in a quantitative radial immunodiffusion assay for measurement of rat fibrinogen and fibrin degradation products. It is a suitable technique for measurement of these parameters in small samples wh...

journal_title：Vox sanguinis

authors： Kaplan JE,Blumenstock FA,Saba TM

更新日期：1979-01-01 00:00:00

abstract：:Albumin is obtainable from human blood plasma by an ion exchange chromatographic procedure in a yield of about 95% and a purity well above Pharmacopoeia requirements. Cryosupernatant, factor IX depleted plasma is precipitated with 12 and 25% w/v polyethylene glycol 4000. The second precipitate is dissolved to 8% w/v p...

journal_title：Vox sanguinis

authors： Curling JM,Berglöf J,Lindquist LO,Eriksson S

更新日期：1977-08-01 00:00:00

abstract：:The risk of non-A, non-B hepatitis transmission by an intravenous immunoglobulin (IVIG) preparation was assessed in a prospective multicenter trial in 68 patients with primary immunodeficiency disorders (40 children or adolescents and 28 adults). During the 4-week prestudy evaluation period the clinical examinations a...

journal_title：Vox sanguinis

authors： Imbach P,Perret BA,Babington R,Kaminski K,Morell A,Heiniger HJ

更新日期：1991-01-01 00:00:00

abstract：:Although we still do not know enough about the influence of anaemia and transfusion on outcomes for the surgical patient, it is possible to develop a general consensus about many aspects of management. A quality programme to improve consistency of practice in these consensus areas is feasible. (Table 6) This should be...

journal_title：Vox sanguinis

authors： McClelland B

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Although transfusion-transmitted infections are rare, non-infectious complications occur relatively frequently. Solvent/detergent-treated fresh-frozen plasma (SD-FFP) has been shown to reduce the frequency of both types of complication, although previous economic evaluations failed to consider...

journal_title：Vox sanguinis

authors： Riedler GF,Haycox AR,Duggan AK,Dakin HA

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Glycocalicin (GC) is a proteolytic fragment of GpIb and can conveniently be measured in supernatants of platelet concentrates (PCs) by means of a sandwich ELISA. Because of the convenience of the assay and easy sample storage, we tested its suitability as a sensitive platelet activation parame...

journal_title：Vox sanguinis

authors： Kostelijk EH,Folman CC,Gouwerok CW,Kramer CM,Verhoeven AJ,de Korte D

更新日期：2000-01-01 00:00:00

abstract：:We report the development of a semi-continuous method for preparation of factor IX complex from human plasma using ion exchange resins. Traditionally, stirred batch adsorption has been used due to the high pressure drops and low flow rates associated with soft gels in packed columns. Batch methods, however, typically ...

journal_title：Vox sanguinis

authors： Tharakan JP,Gee DM,Clark DB

更新日期：1989-01-01 00:00:00

abstract：:The use of granulocyte transfusions in profoundly neutropenic patients has increased markedly in recent years. Whenever a pulmonary infiltrate develops during the course of these transfusions, the question arises as to what role the transfusions are playing and whether the transfusions should be discontinued to preven...

journal_title：Vox sanguinis

authors： Karp DD,Ervin TJ,Tuttle S,Gorgone BC,Lavin P,Yunis EJ

更新日期：1982-02-01 00:00:00

abstract：:Inhibitor development represents the main complication in the treatment of haemophilia A. The risk of inhibitor formation is in part genetically determined by the type of the underlying factor VIII gene lesion but environmental factors may also play an important role. Due to the lack of efficiency of factor VIII in th...

journal_title：Vox sanguinis

authors： Brackmann HH,Schwaab R,Effenberger W,Hess L,Hanfland P,Oldenburg J

更新日期：2000-01-01 00:00:00