Abstract:
:We tested serum samples from 11 HIV-seropositive and 32 HIV-seronegative Italian patients with hemophilia A or B for the presence of lymphocytotoxic antibodies (LCTAs). No patients had the acquired immune deficiency syndrome and all had received over many years heat-untreated commercial clotting factors. LCTAs directed mainly to B cells, were significantly present in 5/6 HIV-seropositive patients with hemophilia A and in 5/5 HIV-seropositive patients with hemophilia B. The presence of LCTAs in HIV-seronegative hemophiliacs was significantly correlated with both a decrease of T cells and an increase in serum levels of IgG and IgM.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Conte R,Giovanardi L,Tazzari PL,De Rosa V,Rodorigo G,Re MCdoi
10.1111/j.1423-0410.1988.tb01612.xsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
47-51issue
1eissn
0042-9007issn
1423-0410journal_volume
54pub_type
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