Hemostasis testing during massive blood replacement. A study of 172 cases.

Abstract:

:A 24-hours service was organized to study changes in the hemostatic system in surgical patients undergoing massive transfusion for excessive bleeding during operation or in the early postoperative period. Hemostasis tests gave normal results in only 12(7%) of the 172 patients, while in the remaining 160(93%) one or more tests gave abnormal results. The platelet count was the most frequently abnormal, followed by the prothrombin time and plasma fibrinogen. Well-defined hemostatic disorders (such as DIC, heparinization and liver disease) were ascertained in 82 patients (48%). 78 patients (45%) had less specific laboratory abnormalities, with a particularly high incidence of thrombocytopenia and less pronounced alterations in the coagulation tests. Unlike the patients with defined disorders, the strong inverse correlation in this group between platelet count, prothrombin time, plasma fibrinogen, and the number of transfusions suggests that the laboratory abnormalities were induced by massive blood replacement. Standard schemas involving the administration of platelet concentrates and/or fresh-frozen plasma without evaluation of hemostasis did not help to reduce the incidence of abnormalities. These measures also failed to decrease the requirements for whole blood and/or packed red cells. Therefore, indiscriminate administration in the massively transfused postoperative patient of blood components based on preestablished schemes appears to be unjustified. An approach based on hemostasis screening, identification of the underlying disorder, directed therapeutic intervention and laboratory monitoring is likely to be more effective.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Mannucci PM,Federici AB,Sirchia G

doi

10.1111/j.1423-0410.1982.tb01080.x

subject

Has Abstract

pub_date

1982-03-01 00:00:00

pages

113-23

issue

3

eissn

0042-9007

issn

1423-0410

journal_volume

42

pub_type

杂志文章
  • Perioperative red cell transfusion: evidence, guidelines and practice.

    abstract::Although we still do not know enough about the influence of anaemia and transfusion on outcomes for the surgical patient, it is possible to develop a general consensus about many aspects of management. A quality programme to improve consistency of practice in these consensus areas is feasible. (Table 6) This should be...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1998.tb05393.x

    authors: McClelland B

    更新日期:1998-01-01 00:00:00

  • Development of white blood cell fragments, during the preparation and storage of platelet concentrates, as measured by using real-time polymerase chain reaction.

    abstract:BACKGROUND AND OBJECTIVES:White blood cell (WBC) fragments may cause human leucocyte antigen (HLA) immunization in recipients. We investigated the occurrence and production of WBC fragments in platelet concentrates (PCs) and plasma units, during storage and filtration, by using real-time polymerase chain reaction (PCR)...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2004.00576.x

    authors: Dijkstra-Tiekstra MJ,van der Schoot CE,Pietersz RN,Huijgens PC,van der Meer PF,Reesink HW

    更新日期:2004-11-01 00:00:00

  • Another Kell-related antibody, anti-K19.

    abstract::A new high-frequency antigen related to the Kell system was defined by the serum of a patient, Mrs. Sub. The antigen was lacking from her cells and those of one of her three siblings. All random cells tested were incompatible with her serum as were bloods of other various "null" phenotypes, but Ko bloods were compatib...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1979.tb04406.x

    authors: Sabo B,McCreary J,Stroup M,Smith DE,Weidner JG

    更新日期:1979-01-01 00:00:00

  • Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow.

    abstract:BACKGROUND AND OBJECTIVE:The objective of the study was to investigate the splanchnic blood flow velocity and oximetry response to blood transfusion in preterm infants according to postnatal age. MATERIALS AND METHODS:Preterm infants receiving blood transfusion were recruited to three groups: 1-7 (group 1; n = 20), 8-...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12436

    authors: Banerjee J,Leung TS,Aladangady N

    更新日期:2016-11-01 00:00:00

  • De novo protein synthesis in mature platelets: a consideration for transfusion medicine.

    abstract::Platelet function in thrombosis and haemostasis is reasonably well understood at the molecular level with respect to the proteins involved in cellular structure, signalling networks and platelet interaction with clotting factors and other cells. However, the natural history of these proteins has only recently garnered...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.2010.01333.x

    authors: Schubert P,Devine DV

    更新日期:2010-08-01 00:00:00

  • Evaluation of the de-selection of men who have had sex with men from blood donation in England.

    abstract:BACKGROUND AND OBJECTIVES:The Blood Services of the UK permanently de-select men who have had sex with men (MSM) from donating blood. The rationale for this has been questioned. This article attempts to evaluate whether this selection criterion does contribute to blood safety. MATERIALS AND METHODS:Data about transfus...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2003.00295.x

    authors: Soldan K,Sinka K

    更新日期:2003-05-01 00:00:00

  • Red blood cell utilization and transfusion triggers in patients diagnosed with chronic lymphocytic leukaemia in Iceland 2003-2016.

    abstract:BACKGROUND AND OBJECTIVES:Revised Icelandic guidelines proposed a restrictive haemoglobin (Hb) threshold of 70 g/l for red blood cell (RBC) transfusions in general, but 100 g/l for malignancies/bone marrow suppression. Chronic lymphocytic leukaemia (CLL) is frequently complicated by anaemia. The objective was to invest...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12775

    authors: Thorvaldsson HH,Vidarsson B,Sveinsdottir SV,Olafsson GB,Halldorsdottir AM

    更新日期:2019-07-01 00:00:00

  • Effect of periodate oxidation on specific activities and carbohydrate components of human blood group N- and M-specific glycoproteins and glycopeptides.

    abstract::Mild as well as strong periodate oxidation of isolated erythrocyte N and M glycoproteins and glycopeptides gave extensive to complete destruction of N-specificities as measured with Vicia graminea extracts and of N- as well as M- activities determined with all but 1 of 8 animal anti-N and 13 anti-M sera. Results with ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1978.tb02931.x

    authors: Springer GF,Yang HJ

    更新日期:1978-01-01 00:00:00

  • Use of segments for the quality control of the factor VIII: coagulant activity of fresh frozen plasma.

    abstract::The storage of fresh frozen plasma (FFP) for short periods at -20 degrees C for 6 weeks, -30 degrees C for 12 weeks, or -40 degrees C for 12 weeks, did not result in significant deterioration in factor VIII: coagulant (factor VIII:C) activity in the primary packs. In studies examining whether plasma segments could be ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00174.x

    authors: Ofosu FA,Blajchman MA,Kaegi A,Turc JM

    更新日期:1985-01-01 00:00:00

  • Paediatric transfusion.

    abstract::The requirements of children undergoing transfusion should be considered as a distinct entity from those of adults. Neonates are particularly vulnerable and there have been concerns over infective or toxic risks to this group. Neonates may also have more acute side-effects as a result of their small blood volume. Most...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.2006.00722.x

    authors: New HV

    更新日期:2006-01-01 00:00:00

  • Efficiency of leukocyte removal by filters made of superfine glass fiber membranes.

    abstract:BACKGROUND AND OBJECTIVES:To demonstrate the application of leukocyte removal filters made of a new type of filter material - superfine glass fiber - for depleting leukocytes in SAGM red cell suspensions and preventing nonhemolytic transfusion reactions. MATERIALS AND METHODS:The extent of leukocyte depletion and red ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1159/000031015

    authors: Zou Y,Sun Q,Li A,Yao F,Hu Z,Li Z L,Ma W

    更新日期:1999-01-01 00:00:00

  • Platelet-rich plasma and platelet gel preparation using Plateltex.

    abstract:BACKGROUND:The platelet gel is made by embedding concentrate platelets within a semisolid (gel) network of polymerized fibrin. It is believed that this blood component will be used more and more in the treatment of several clinical conditions and as an adjunctive material in tissue engineering. Several systems are avai...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2007.01027.x

    authors: Mazzucco L,Balbo V,Cattana E,Borzini P

    更新日期:2008-04-01 00:00:00

  • Patient-specific transfusion-related acute lung injury.

    abstract::Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusion-associated mortality. The inadvertent transfusion of neutrophil antibodies can cause pulmonary transfusion reactions and TRALI. However, not all patients transfused with neutrophil antibodies experience transfusion reactions. A 2...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2007.00982.x

    authors: Muniz M,Sheldon S,Schuller RM,Young NS,Klein HG,Leitman SF,Stroncek DF

    更新日期:2008-01-01 00:00:00

  • Value of central analysis of leucocyte depletion quality control data within the National Blood Service, England.

    abstract:BACKGROUND AND OBJECTIVES:The results of quality monitoring leucocyte counts were analysed nationally for the first 2 years of universal leucocyte depletion (LD), spanning the time-period before and after standardization of the counting and LD methods. The objectives were twofold: first to determine whether the impleme...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2002.00210.x

    authors: Beckman N,Cardigan R,Wallington T,Williamson LM

    更新日期:2002-08-01 00:00:00

  • White blood cell fragments in platelet concentrates prepared by the platelet-rich plasma or buffy-coat methods.

    abstract:BACKGROUND AND OBJECTIVES:White blood cell (WBC) fragments in platelet concentrates (PCs) may induce allo-immunization in the recipient. MATERIALS AND METHODS:As the level of WBC fragments can differ between PCs produced using different methods, we compared PCs prepared by using the buffy-coat method (BC-PCs) in plasm...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2005.00634.x

    authors: Dijkstra-Tiekstra MJ,van der Schoot CE,Pietersz RN,Reesink HW

    更新日期:2005-05-01 00:00:00

  • Application of the gel test in IgG subclassing--a comparison of two agglutination assays.

    abstract:BACKGROUND AND OBJECTIVES:IgG subclasses of anti-D seem to play some role in hemolytic disease of the newborn, but there has been disagreement as to its exact nature. The aim of our study was to evaluate a new technique for IgG subclassing of anti-D and to compare it to an established test. MATERIALS AND METHODS:In 31...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1997.7220114.x

    authors: Palfi M,Hildén JO

    更新日期:1997-01-01 00:00:00

  • Mimicking anti-S simulating a delayed transfusion reaction.

    abstract::An autoantibody mimicking anti-S specificity is described in an S-s+ patient. The antibody was detected 2 weeks after transfusion. The direct antiglobulin test (DAT) was positive and the antibody was thought to be an alloantibody formed after the transfusion. Eighteen months later, the DAT was still positive and anti-...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1987.tb04944.x

    authors: Puig N,Carbonell F,Soler MA,Perez MT,Arriaga F,Marty ML

    更新日期:1987-01-01 00:00:00

  • Current status of oxygen carriers ('blood substitutes'): 2006.

    abstract::An alternative to blood transfusion, based on oxygen-carrying solutions, has been sought for over a century. The present 'first-generation' haemoglobin-products were based on observations that crosslinking with, for example, glutaraldehyde, overcame subunit dissociation and renal toxicity. Experience with these soluti...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.2006.00789.x

    authors: Winslow RM

    更新日期:2006-08-01 00:00:00

  • Cytomegalovirus (CMV) antibody in male homosexuals: a source for CMV immune globulin.

    abstract::Male homosexuals have been found to have an extraordinarily high prevalence, and high titers, of antibodies to cytomegalovirus (CMV), as determined by complement-fixation and passive hemagglutination tests. These findings support other data suggesting that CMV may be sexually transmitted. The high titers of CMV antibo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1983.tb01881.x

    authors: Ikram H,Prince AM,Baker LN

    更新日期:1983-03-01 00:00:00

  • Post-thaw viable CD34(+) cell count is a valuable predictor of haematopoietic stem cell engraftment in autologous peripheral blood stem cell transplantation.

    abstract:BACKGROUND AND OBJECTIVES:In peripheral blood stem cell transplantation, the number of CD34(+) cells infused is considered a predictor of haematopoietic engraftment. However, the currently accepted minimal threshold of CD34(+) cells/kg was determined by counting CD34(+) cells before freezing, and the loss of viable CD3...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2007.01009.x

    authors: Lee S,Kim S,Kim H,Baek EJ,Jin H,Kim J,Kim HO

    更新日期:2008-02-01 00:00:00

  • Autoimmune hemolytic anemia associated with autoanti-Ge.

    abstract::The first reported example of autoimmune hemolytic anemia due to an autoanti-Gerbich is described. The patient's red blood cells exhibited a strongly positive direct antiglobulin test with both IgG and complement antiglobulin reagents. The serum contained a potent antibody which produced agglutination of red blood cel...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1981.tb01015.x

    authors: Reynolds MV,Vengelen-Tyler V,Morel PA

    更新日期:1981-01-01 00:00:00

  • Use of a (proposed) standard protocol to validate Terumo TSCD-II connections between dissimilar blood bag tubing.

    abstract:BACKGROUND AND OBJECTIVES:ISO standards for blood bags do not adequately define and control the dimensions of blood bag transfer tubing. This lack of standardization presents potential difficulties when making sterile connections between the wide range of tubing that has evolved in the absence of such standards. We aim...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2006.00832.x

    authors: Nightingale MJ,Lees B,Biset R,Mertens W

    更新日期:2006-10-01 00:00:00

  • Immune tolerance protocols using low-dose factor VIII: a review of the literature.

    abstract::Low-dose immune tolerance protocols use doses of factor VIII of less than 50 IU/kg/day to induce immune tolerance. Such protocols are chosen for a variety of reasons including cost, patient acceptability and ease of administration. Early published reports of low-dose protocols appeared in 1981, described small numbers...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1159/000056718

    authors: Sultan Y

    更新日期:1999-01-01 00:00:00

  • Inefficacy of plasma exchange in cold agglutinin hemolytic anemia--a case study.

    abstract::A therapeutic trial of plasma exchange was conducted in an 82-year-old woman with severe cold agglutinin hemolytic anemia, who was unresponsive to conventional treatment. In spite of considerable improvement of pertinent parameters (total IgM, cold agglutinin titer and thermal amplitude) this treatment failed to induc...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00763.x

    authors: Rodenhuis S,Maas A,Hazenberg CA,Das PC,Nieweg HO

    更新日期:1985-01-01 00:00:00

  • Resuscitation fluids.

    abstract:BACKGROUND AND OBJECTIVES:The aim of this review was to summarize the properties of the commonly available resuscitation fluids and highlight where knowledge of the characteristics of individual fluids might guide their use in clinical practice. Some of the current controversies surrounding resuscitation fluids are als...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1046/j.1423-0410.2002.00123.x

    authors: Grocott MP,Hamilton MA

    更新日期:2002-01-01 00:00:00

  • A new therapeutic antibody removal method using antigen-positive red cells. II. Application to a P-incompatible pregnant woman.

    abstract::Therapeutic antibody removal using antigen-positive red cells was applied to a pregnant woman who has high titered IgG anti-P and had lost all of 4 previous fetuses in P-incompatible pregnancy. The treatment was commenced at the 6th week of gestation and was intensively performed 93 times up to the 35th week. The volu...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb01589.x

    authors: Yoshida H,Ito K,Emi N,Kanzaki H,Matsuura S

    更新日期:1984-01-01 00:00:00

  • Severe neonatal alloimmune thrombocytopenia due to anti-HPA-3a.

    abstract:BACKGROUND AND OBJECTIVES:Neonatal alloimmune thrombocytopenia is usually attributable to HPA-la antibodies. We report a case of parental platelet antigen incompatibility associated with a severe neonatal thrombocytopenia secondary to alloimmunization to HPA-3a. MATERIALS AND METHODS:Platelet antibodies were detected ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: Boehlen F,Kaplan C,de Moerloose P

    更新日期:1998-01-01 00:00:00

  • Persistence of Parvovirus B19 (B19V) DNA and humoral immune response in B19V-infected blood donors.

    abstract:BACKGROUND AND OBJECTIVES:Parvovirus B19 (B19V) DNA seems to persist in the plasma of B19V-infected blood donors. The relevance of this for recipients of single-donor blood components is yet unclear. MATERIAL AND METHODS:We studied serial archive and follow-up samples from 75 B19V-infected blood donors to obtain more ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12162

    authors: Juhl D,Görg S,Hennig H

    更新日期:2014-10-01 00:00:00

  • Group O RBCs: where is universal donor blood being used.

    abstract:BACKGROUND:There have been recurrent shortages of group O blood due to insufficient inventory and use of group O blood in ABO non-identical recipients. We performed a 12-year retrospective study to determine utilization of group O Rh-positive and Rh-negative red blood cells (RBCs) by recipient ABO group. Reasons for tr...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12492

    authors: Barty RL,Pai M,Liu Y,Arnold DM,Cook RJ,Zeller MP,Heddle NM

    更新日期:2017-05-01 00:00:00

  • World Health Organization collaborative study to calibrate the 3rd International Standard for Hepatitis C virus RNA nucleic acid amplification technology (NAT)-based assays.

    abstract:BACKGROUND AND OBJECTIVES:A collaborative study was undertaken to evaluate a replacement World Health Organization International Standard for hepatitis C virus (HCV) RNA for nucleic acid amplification technology (NAT)-based assays. The candidate preparations were calibrated in International Units (IUs). MATERIALS AND ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1423-0410.2010.01434.x

    authors: Baylis SA,Heath AB,Collaborative Study Group.

    更新日期:2011-05-01 00:00:00