Abstract：
BACKGROUND AND OBJECTIVES:White blood cell (WBC) fragments in platelet concentrates (PCs) may induce allo-immunization in the recipient. MATERIALS AND METHODS:As the level of WBC fragments can differ between PCs produced using different methods, we compared PCs prepared by using the buffy-coat method (BC-PCs) in plasma or platelet additive solution (Composol) and PCs prepared using the platelet-rich plasma method (PRP-PCs). RESULTS:Post-filtration results revealed identical levels of WBC, but significantly higher CD62p expression and a significantly lower amount of total DNA, cell-free DNA and number of WBC fragments (0.6 vs. 4.2 WBC equivalents/microl) in PRP-PCs than in BC-PCs in either plasma or Composol. CONCLUSIONS:The number of WBC fragments is significantly higher in BC-PCs than in PRP-PCs.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Dijkstra-Tiekstra MJ,van der Schoot CE,Pietersz RN,Reesink HWdoi
10.1111/j.1423-0410.2005.00634.xsubject
Has Abstractpub_date
2005-05-01 00:00:00pages
275-7issue
4eissn
0042-9007issn
1423-0410pii
VOX634journal_volume
88pub_type
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