Alpha 2,3-specific desialylation of human red cells: effect on the autoantigens of the Pr, Sa and Sia-l1, -b1, -lb1 series.

Abstract:

BACKGROUND AND OBJECTIVES:Pr1,2,3, PrM, Sa and Sia-l1, -b1, -lb1 are sialic acid (NeuNAc)-dependent antigens recognized by human cold agglutinins. Pr and Sa antigens are the O-glycans of glycophorins containing alpha 2,3NeuNAc (to galactose) and/or alpha 2,6NeuNAc (to galactosamine). The antigens of the Sia-l1, -b1, -lb1 complex are gangliosides that may carry alpha 2,3NeuNAc (to galactose) and/or alpha 2,8NeuNAc (to NeuNAc). We studied the NeuNAc groups involved in the antigens. MATERIALS AND METHODS:From 74 sera with cold agglutinins against NeuNAc-dependent antigens, anti-T-free preparations were made and tested against human red cells, treated with an alpha 2,3-specific recombinant sialidase. RESULTS:Most (51/62) Pr antigens use alpha 2,3NeuNAc, some (8/62) use alpha 2,6NeuNAc and a few (3/62) use both sialyl groups as immunodominant components on glycophorins. The immunodominant component of Sa and Sia-l1, -b1, -lb1 determinants was alpha 2,3NeuNAc in all cases. CONCLUSION:The red cell target structures for cold agglutinins against NeuNAc-dependent antigens have been identified. We propose a Pr nomenclature to reflect this. The binding of anti-Pr to gangliosides may be the basis for anti-Pr-induced peripheral neuropathy.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Roelcke D,Hack H,Kreft H,Gross HJ

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

109-12

issue

2

eissn

0042-9007

issn

1423-0410

pii

vox74109

journal_volume

74

pub_type

杂志文章
  • Lactated Ringer's solution versus hydroxyethyl starch for volume replacement in autologous blood donors with cardiovascular disease: a controlled, randomized trial.

    abstract:BACKGROUND AND OBJECTIVES:The study was designed to evaluate whether volume replacement following blood donation can prevent arterial hypotension in autologous blood donors with cardiovascular disease. MATERIALS AND METHODS:One hundred nineteen autologous blood donors with known cardiovascular disease were randomly al...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kasper SM,Dahlmann H,Mellinghoff H,Ellering J,Baumann M,Buzello W

    更新日期:1998-01-01 00:00:00

  • BS II lectin: a second hemagglutinin isolated from Bandeiraea simplicifolia seeds with affinity for type III polyagglutinable red cells.

    abstract::BS II lectin, a second hemagglutinin isolated from Bandeiraea simplicifolia seeds, agglutinated the red cells from 11 patients manifesting the 'acquired B' antigen phenomenon. The results of serological studies indicate that this lectin has specificity for the type III polyagglutinable receptors rather than for the 'B...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1977.tb04469.x

    authors: Judd WJ,Beck ML,Hicklin BL,Iyer PN,Goldstein IJ

    更新日期:1977-10-01 00:00:00

  • Supernatants of stored polymorphonuclear neutrophils exhibit growth-promoting activity in several cell lines: perforin expression in polymorphonuclear neutrophils and its role in down-regulation of growth-promoting activity.

    abstract:BACKGROUND AND OBJECTIVES:Polymorphonuclear neutrophils (PMNs) play important roles in the host immune defence. This study was performed to identify roles of PMNs other than those already known. MATERIALS AND METHODS:PMNs were separated from the peripheral blood of healthy individuals and stored in vitro for 24 h in t...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2002.00156.x

    authors: Nishimura M,Mitsunaga S,Juji T

    更新日期:2002-04-01 00:00:00

  • A family with allo-immune neonatal neutropenia: group-specific pathogenicity of maternal antibodies.

    abstract::A family is presented, in which the mother developed strong neutrophil granulocyte-specific antibodies with the specificity anti-NA. The first and third children, both NA1-positive, suffered from severe transient neonatal neutropenia, but the second child, NA1-negative, did not. Anti-NA1 antibodies were detectable in ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1979.tb04390.x

    authors: Verheugt FW,van Noord-Bokhorst JC,von dem Borne AE,Engelfriet CP

    更新日期:1979-01-01 00:00:00

  • CD36 autoantibodies and thrombotic diathesis, thrombocytopenia and repeated early fetal losses.

    abstract:BACKGROUND AND OBJECTIVES:Autoantibodies to CD36, a platelet glycoprotein, have been found in patients with thrombotic thrombocytopenic purpura, and in those with lupus-like anticoagulant with thrombotic complications. MATERIALS AND METHODS:Conventional hematologic and laboratory methods were used. The patient was a p...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1997.7310046.x

    authors: Borzini P,Riva M,Nembri P,Rossi E,Pagliaro P,Vergani P,Greppi P,Tantardini P

    更新日期:1997-01-01 00:00:00

  • Monoclonal antibody recognizing a unique Rh-related specificity.

    abstract::A mouse IgG1 monoclonal antibody (MAb) UMRh, was prepared by immunizing Balb/c mice with the Jurkat T cell acute lymphoblastic leukemia (T-ALL) cell line. The MAb UMRh is directed against a widely distributed Rh-related cell surface antigen, present on red blood cells (RBCs) expressing the more common Rh phenotypes. T...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1993.tb03061.x

    authors: Poss MT,Swanson JL,Telen MJ,Lasky LC,Vallera DA

    更新日期:1993-01-01 00:00:00

  • Severe thrombocytopenia due to host-derived anti-HPA-1a after non-myeloablative allogeneic haematopoietic stem cell transplantation for multiple myeloma: a case report.

    abstract:BACKGROUND AND OBJECTIVES:Host- or donor-derived alloimmune thrombocytopenia can develop after non-myeloablative allogeneic haematopoietic stem cell transplantation (HSCT). We report the first case of host-derived HPA-1a antibodies. CASE REPORT:A 52-year-old male patient received HSCT from his human leucocyte antigen ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2005.00692.x

    authors: Macher S,Schallmoser K,Staber PB,Neumeister P,Posch U,Lanzer G,Panzer S

    更新日期:2005-11-01 00:00:00

  • Multiple epitopes recognised by human monoclonal IgM anti-D antibodies.

    abstract::Bivalent 7S subunits were obtained from 7 purified IgM human monoclonal anti-D antibodies with 33-63% of the total protein-retaining functional binding activity. The number of sites per red cell recognized by these subunits ranged between 9,400 and 28,500. The values are taken to indicate that a number of different ep...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1990.tb05021.x

    authors: Hughes-Jones NC,Gorick BD,Beale D

    更新日期:1990-01-01 00:00:00

  • Interactions between science, government and media on selection and testing of donors.

    abstract::The international media attention to "bad blood" has fueled governmental action in countries around the world. Donor selection criteria continue to expand, focusing most recently on the possibility of exclusion due to intranasal cocaine use and, in the US, due to incarceration for more than 72 hours. As newer methods ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1998.tb05465.x

    authors: Sazama K

    更新日期:1998-01-01 00:00:00

  • The effects of leg crossing and applied tension on blood donor return.

    abstract:BACKGROUND AND OBJECTIVES:Repeated isometric muscle tension (applied tension) during blood donation reduces vasovagal symptoms in many donors. Experiencing vasovagal symptoms has been found to reduce blood donor return. However, does practicing applied tension improve blood donor return? Follow-up results from a random...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/vox.12055

    authors: Ditto B,Gilchrist PT,Holly CD,Dubuc S,Delage G,France CR

    更新日期:2013-11-01 00:00:00

  • Hemostasis testing during massive blood replacement. A study of 172 cases.

    abstract::A 24-hours service was organized to study changes in the hemostatic system in surgical patients undergoing massive transfusion for excessive bleeding during operation or in the early postoperative period. Hemostasis tests gave normal results in only 12(7%) of the 172 patients, while in the remaining 160(93%) one or mo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1982.tb01080.x

    authors: Mannucci PM,Federici AB,Sirchia G

    更新日期:1982-03-01 00:00:00

  • A new intact immunoglobulin for intravenous use stabilized by chemically modified gelatin derivatives.

    abstract::The stabilization of human immunoglobulin (IgG) by chemically modified gelatins (Haemaccel and Gelofusine) was investigated. The gelatins prevented IgG from aggregation induced by exposure to interfaces and lyophilization. The stabilization effects of the gelatins were significantly larger than those of amino acids or...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb00219.x

    authors: Tomono T,Ikeda K,Suzuki T

    更新日期:1986-01-01 00:00:00

  • Parallel comparison of apheresis-collected platelet concentrates stored in four different additive solutions.

    abstract:BACKGROUND AND OBJECTIVES:Partially replacing plasma with additive solutions in platelet (PLT) concentrates (PCs) may help to reduce transfusion reactions. Constituents of PLT additive solutions (PASs) have been revealed to affect the quality of PCs. Previous studies involved pairwise comparison of identical PLTs with ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12064

    authors: Nogawa M,Naito Y,Chatani M,Onodera H,Shiba M,Okazaki H,Matsuzaki K,Satake M,Nakajima K,Tadokoro K

    更新日期:2013-11-01 00:00:00

  • Non-A, non-B hepatitis and the anti-HCV assay.

    abstract::The successful cloning of a non-structural antigen from the genome of what is now designated as the 'hepatitis C virus' (HCV) has transformed an erstwhile diagnosis of exclusion for non-A, non-B hepatitis (NANBH). The assay has been validated against panels of known infectivity for NANBH and sera from haemophiliac pat...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1991.tb00863.x

    authors: Barbara JA,Contreras M

    更新日期:1991-01-01 00:00:00

  • Inefficacy of plasma exchange in cold agglutinin hemolytic anemia--a case study.

    abstract::A therapeutic trial of plasma exchange was conducted in an 82-year-old woman with severe cold agglutinin hemolytic anemia, who was unresponsive to conventional treatment. In spite of considerable improvement of pertinent parameters (total IgM, cold agglutinin titer and thermal amplitude) this treatment failed to induc...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00763.x

    authors: Rodenhuis S,Maas A,Hazenberg CA,Das PC,Nieweg HO

    更新日期:1985-01-01 00:00:00

  • KEL*02 alleles with alterations in and around exon 8 in individuals with apparent KEL:1,-2 phenotypes.

    abstract:BACKGROUND AND OBJECTIVES:Antibodies to antigens in the Kell blood group system, especially anti-KEL1, are involved in both haemolytic disease of the newborn and foetus and haemolytic transfusion reactions. Correct typing results are important and discrepancies between serologic and genetic typing must be resolved. Her...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2010.01334.x

    authors: Wester ES,Steffensen R,Ligthart PC,Vad J,de Haas M,Storry JR,Olsson ML

    更新日期:2010-08-01 00:00:00

  • Alloimmunization against Iy, a low-frequency antigen on platelet glycoprotein Ib/IX as a cause of severe neonatal alloimmune thrombocytopenic purpura.

    abstract::Neonatal alloimmune thrombocytopenia (NAIT) is usually induced by platelet-specific antibodies against HPA-1a (Zwa) or HPA-5b (Bra). Recently, low-frequency alloantigens on the platelet glycoprotein (GP) IIb/IIIa complex have been discovered as a cause for NAIT. In this report, a new low-frequency platelet-specific al...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1995.tb02604.x

    authors: Kiefel V,Vicariot M,Giovangrandi Y,Kroll H,Böhringer M,Greinacher A,Breitfeld C,Santoso S,Mueller-Eckhardt C

    更新日期:1995-01-01 00:00:00

  • A new low-frequency antigen BOW (Bowyer).

    abstract::BOW is a 'new' low-frequency red-cell antigen, detected in 2 unrelated English blood donors, that is sensitive to alpha-chymotrypsin and pronase. Anti-BOW is present in many polyspecific reagents used to define low-frequency antigens. Red-cell groups of the proposita, R.B., and her family show that the BOW blood group...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1988.tb04705.x

    authors: Chaves MA,Leak MR,Poole J,Giles CM

    更新日期:1988-01-01 00:00:00

  • Platelets stored in a new-generation container differences between plasma and platelet additive solution II.

    abstract:BACKGROUND AND OBJECTIVES:In order to preserve platelet concentrates (PCs) with high yields, a new polyolefin platelet storage container (PL 2410, 1.3L, Baxter, La Châtre, France) with increased gas permeability in combination with a larger surface area has been developed. The storage capacity was studied with platelet...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: de Wildt-Eggen J,Schrijver JG,Smid WM,Joie M,Bollinne V,Bins M

    更新日期:1998-01-01 00:00:00

  • Positive direct antiglobulin test due to antiphospholipid antibodies in normal healthy blood donors.

    abstract:OBJECTIVES:Positive direct antiglobulin tests (DAT) occur occasionally, without obvious cause, among normal blood donors. This is sometimes associated with a false-positive serologic test for syphilis. Positive DATs due to antiphospholipid antibodies (APAbs) are well documented in the antiphospholipid syndrome with sys...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1997.7230182.x

    authors: Win N,Islam SI,Peterkin MA,Walker ID

    更新日期:1997-01-01 00:00:00

  • Accumulation of soluble inflammatory mediators between blood donation and pre-storage leucocyte depletion.

    abstract:BACKGROUND AND OBJECTIVES:Leucocyte-derived cytokines accumulate in stored whole blood. Pre-storage leucocyte depletion has reduced cytokine levels and, consequently, febrile non-haemolytic transfusion reactions. As leucocyte filtration and component separation can be performed until 24 h after donation, we hypothesize...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2008.01132.x

    authors: Chudziak D,Sireis W,Pfeiffer HU,Henschler R,Seifried E,Bönig H

    更新日期:2009-02-01 00:00:00

  • Screening blood donors for Plasmodium falciparum malariae. Application of ready-to-use homologous antigens.

    abstract::Prevention of post-transfusion malaria remains a worrying problem. Until now it was very difficult to obtain homologous antigens, and immunologic methods used to detect malaria were expensive. We tested the ready-to-use Plasmodium falciparum prepared slides using the IFA (indirect fluorescent antibody) test on 866 sel...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1983.tb01933.x

    authors: Deroff P,Reguer M,Simitzis AM,Boudon A,Saleun JP

    更新日期:1983-01-01 00:00:00

  • Model for the Rh blood group system based on discontinuous gene structure.

    abstract::A model of the Rh blood group system is proposed which is based on discontinuous gene structure. The R29 control subregion consists of a single exon flanked by introns. Following the R29 subregion, the R1 subregion exists as seven exon structures which alternate with introns. The expression of each exon is controlled ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1981.tb01022.x

    authors: Giorno R

    更新日期:1981-01-01 00:00:00

  • Application of the OCR-B symbol in the data-processing system of the Finnish Red Cross Blood Transfusion Service.

    abstract::We have used the Optical Character Recognition system B (OCR-B) for automatic identification of blood samples on the Groupamatic 360 and in connection with computerized donor file management and control of blood product processing. For the Groupamatic system a device was constructed that lifts that samples, and during...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: Haahti E,Leikola J,Ruikka S

    更新日期:1981-03-01 00:00:00

  • Phenotype prediction by DNA-based typing of clinically significant blood group systems in Jordanian blood donors.

    abstract:BACKGROUND AND OBJECTIVES:During the past 10 years several DNA-typing methods have been developed to complement routine serological typing for determination of polymorphisms in the ABO, RH, KEL, JK and FY blood group genes. However, the molecular basis of blood groups can differ widely between ethnic groups. The purpos...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2002.00182.x

    authors: Irshaid NM,Ramadan S,Wester ES,Olausson P,Hellberg A,Merza JY,Olsson ML

    更新日期:2002-07-01 00:00:00

  • A Swiss family showing independent segregation of the Lutheran and Swann genes.

    abstract::A family is reported in which the parents' mating is of the 'double back-cross' type with respect to the Sw, Lu and Se genes. The inheritance of these genes in the children shows, with reference to a possible linkage between Sw and the two other loci, four non-recombinants and three recombinants (or vice versa). The i...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb02221.x

    authors: Metaxas MN,Metaxas-Buehler M

    更新日期:1976-01-01 00:00:00

  • Population study of heterophile antibodies.

    abstract::Sera from 2,829 participants in a population health survey were tested for the presence of a heterophilic antibody, detectable by immunofluorescence. The antibody was found in 9.8% of the sera from women and in 12.4% of the sera from men. The age-specific prevalence of the antibody was relatively constant in women but...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1980.tb02973.x

    authors: Hawkins BR,Saueracker GC,Dawkins RL,Davey MG,O'Connor KJ

    更新日期:1980-12-01 00:00:00

  • Lectin studies. III. A survey of phytohemagglutinins: interaction of lectins with erythrocytes of ten vertebrate species.

    abstract::Extracts of seeds from 79 plant species were tested for agglutinating and lytic activity with the red cells of ten vertebrate species (man, monkey, rabbit, rat, goat, sheep, guinea pig, horse, fowl, dog). Of these extracts, 24 were hemagglutinating and 15 were hemolytic. The results suggest that some lectins can serve...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1978.tb02928.x

    authors: Bhalla V,Gaur V,Bhatia K

    更新日期:1978-01-01 00:00:00

  • Therapeutic efficacy of platelet components treated with amotosalen and ultraviolet A pathogen inactivation method: results of a meta-analysis of randomized controlled trials.

    abstract:BACKGROUND AND OBJECTIVES:There are conflicting data regarding the therapeutic efficacy of platelets inactivated using amotosalen and ultraviolet A light. We have performed a meta-analysis to summarize the results of different randomized controlled trials (RCT). MATERIALS AND METHODS:Five RCTs reported through March 2...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1423-0410.2012.01614.x

    authors: Cid J,Escolar G,Lozano M

    更新日期:2012-11-01 00:00:00

  • Photoinactivation of Leishmania donovani infantum in red cell suspensions by a flexible thiopyrylium sensitizer.

    abstract:BACKGROUND AND OBJECTIVES:Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania, which are intracellular parasites of monocytes and macrophages. Transmission of the organism has been observed by transfusion of infected blood from asymptomatic donors to immunocompromised recipients, leading to...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2006.00810.x

    authors: Wagner SJ,Skripchenko A,Salata J,Cardo LJ

    更新日期:2006-08-01 00:00:00