Abstract:
BACKGROUND AND OBJECTIVES:Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania, which are intracellular parasites of monocytes and macrophages. Transmission of the organism has been observed by transfusion of infected blood from asymptomatic donors to immunocompromised recipients, leading to clinically apparent disease. There is no licensed Leishmania screening test currently available. MATERIALS AND METHODS:This study investigated the potential for a novel DNA-intercalating photosensitizer, thiopyrylium (TP), to inactivate Leishmania donovani infantum in red cell (RBC) suspensions. RESULTS:A 5.7 TCID50 reduction of Leishmania was observed in samples treated with 12.5 micromole l(-1) TP and 1.1 J cm(-2) light. CONCLUSIONS:Leishmania is highly sensitive to photoinactivation under conditions that have been previously demonstrated to maintain RBC properties during 42 days of storage.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Wagner SJ,Skripchenko A,Salata J,Cardo LJdoi
10.1111/j.1423-0410.2006.00810.xsubject
Has Abstractpub_date
2006-08-01 00:00:00pages
178-80issue
2eissn
0042-9007issn
1423-0410pii
VOX810journal_volume
91pub_type
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