Abstract:
:The commercial immune serum globulin (ISG) product is suitable for use in passive immunization only by intramuscular administration; intravenous use results in vasomotor side reactions. We report the functional characterization of a chemically modified ISG (MISG) that is essentially free of nonspecific complement-binding activity and contains no new antigenic determinants. The half-life values for MISG given intravenously to rabbits, guinea pigs, and humans are shown not to be different from that of ISG. The MISG we describe is shown to fulfill the in vitro and in vivo criteria of stability, safety, function, and half-life, making it suitable for human intravenous administration.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Schroeder DD,Tankersley DL,Lundblad JLdoi
10.1111/j.1423-0410.1981.tb00726.xsubject
Has Abstractpub_date
1981-01-01 00:00:00pages
383-94issue
6eissn
0042-9007issn
1423-0410journal_volume
40pub_type
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