Cost-effectiveness of solvent/detergent-treated fresh-frozen plasma.

Abstract:

BACKGROUND AND OBJECTIVES:Although transfusion-transmitted infections are rare, non-infectious complications occur relatively frequently. Solvent/detergent-treated fresh-frozen plasma (SD-FFP) has been shown to reduce the frequency of both types of complication, although previous economic evaluations failed to consider non-infective events and subsequently underestimated the benefits of SD-FFP. MATERIALS AND METHODS:A time-series analytical model was used to estimate the incremental cost/life year saved for SD-FFP compared with untreated FFP, having controlled for post-transfusion mortality and patient age. Various infective and non-infective transfusion-related complications were considered. RESULTS:The discounted cost/life year saved for SD-FFP use in the UK was pound sterling 22,728 [95% confidence interval (95% CI): pound sterling 22,604-22,853] for neonates and pound sterling 98,465 (95% CI: pound sterling 97,924-99,005) for patients aged 70. The cost-effectiveness ratio was below pound sterling 50,000/life year saved for patients < or = 48 years of age, and below pound sterling 30,000/life year saved for those < or = 21 years of age. In transfusion recipients with no significant morbidity, the cost-effectiveness ratio was pound sterling 12,335 for neonates and pound sterling 61,692 for 70-year olds. The most important driver of cost-effectiveness was transfusion-related acute lung injury (TRALI), on account of its relatively high incidence and mortality rate. CONCLUSIONS:Previous analyses greatly underestimated the cost-effectiveness of SD-FFP. Inclusion of non-infectious complications suggests that SD-FFP is cost-effective in patients < or = 48 years of age and in older patients with good clinical prognosis, which may justify the wider use of this technology.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Riedler GF,Haycox AR,Duggan AK,Dakin HA

doi

10.1046/j.1423-0410.2003.00329.x

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

88-95

issue

2

eissn

0042-9007

issn

1423-0410

pii

329

journal_volume

85

pub_type

杂志文章
  • Oral antiplatelet therapy: impact for transfusion medicine.

    abstract::Patients on antiplatelet therapy, be it aspirin only, or aspirin in combination with oral adenosine diphosphate (ADP) receptor inhibitors like clopidogrel, prasugrel and ticagrelor, or the protease-activated receptor-1 inhibitor vorapaxar, may develop bleeding or need transient reversal of platelet blockade for acute ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/vox.12537

    authors: Gremmel T,Panzer S

    更新日期:2017-08-01 00:00:00

  • Molecular genetic analysis of the ABO blood group system: 3. A(X) and B(A) alleles.

    abstract::We have employed a PCR approach to determine the nucleotide sequences of the coding region in the last two coding exons of the histo-blood group ABO genes from one A(X) and one B(A) individual. Compared with A1 alleles, the (A(X)) allele has a single nucleotide substitution (T-->A at nucleotide 646) resulting in an am...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1993.tb05157.x

    authors: Yamamoto F,McNeill PD,Yamamoto M,Hakomori S,Harris T

    更新日期:1993-01-01 00:00:00

  • Organizational models for health actions in the field of blood and blood products in Brazilian and Spanish regional contexts.

    abstract:BACKGROUND AND OBJECTIVES:This article aims to characterize some elements that define the organizational models of healthcare actions in the field of blood and blood products. MATERIALS AND METHODS:This exploratory and qualitative study was carried out based on a documentary survey complemented by interviews with key ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12665

    authors: Souza MKB

    更新日期:2018-05-21 00:00:00

  • Prevalence of GBV-C/hepatitis G virus viremia and anti-E2 in Canadian blood donors.

    abstract:BACKGROUND AND OBJECTIVES:GB virus C (GBV-C)/hepatitis G virus (HGV) is a recently recognized parenterally and sexually transmitted agent. The prevalence of GBV-C/HGV markers in Canadian blood donors has not been previously studied and was therefore determined. MATERIALS AND METHODS:Blood donors [identity unlinked (IU...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1159/000056731

    authors: Giulivi A,Slinger R,Tepper M,Sher G,Scalia V,Kessler G,Gill P

    更新日期:2000-01-01 00:00:00

  • BS II lectin: a second hemagglutinin isolated from Bandeiraea simplicifolia seeds with affinity for type III polyagglutinable red cells.

    abstract::BS II lectin, a second hemagglutinin isolated from Bandeiraea simplicifolia seeds, agglutinated the red cells from 11 patients manifesting the 'acquired B' antigen phenomenon. The results of serological studies indicate that this lectin has specificity for the type III polyagglutinable receptors rather than for the 'B...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1977.tb04469.x

    authors: Judd WJ,Beck ML,Hicklin BL,Iyer PN,Goldstein IJ

    更新日期:1977-10-01 00:00:00

  • Platelet storage media.

    abstract::Present platelet storage media often designated platelet additive solutions (PAS) basically contain acetate, citrate and phosphate and recently also potassium and magnesium. However, there seems to be an increasing interest in developing PASs that can be used also after further reduction of residual plasma content bel...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/vox.12172

    authors: Gulliksson H

    更新日期:2014-10-01 00:00:00

  • Collaborative study to establish a replacement World Health Organization International Standard for parvovirus B19 DNA nucleic acid amplification technology (NAT)-based assays.

    abstract:BACKGROUND AND OBJECTIVES:The aim of the study was to replace the 1(st) World Health Organization International Standard for parvovirus B19 DNA for nucleic acid amplification technique (NAT)-based assays (code 99/800). Two lyophilized preparations (coded 99/800 and 99/802) had been evaluated in the original collaborati...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1423-0410.2009.01288.x

    authors: Baylis SA,Chudy M,Blümel J,Pisani G,Candotti D,José M,Heath AB

    更新日期:2010-04-01 00:00:00

  • A new liquid, intravenous immunoglobulin product (IGIV 10%) highly purified by a state-of-the-art process.

    abstract:BACKGROUND AND OBJECTIVES:The ultimate goal was to generate an industrial-scale process suitable to produce a high-yield, safe and stable immunoglobulin G (IgG) preparation for intravenous administration, which is ready to use for customer convenience. This new liquid 10% IgG preparation (IGIV 10%) was compared to Gamm...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2006.00846.x

    authors: Teschner W,Butterweck HA,Auer W,Muchitsch EM,Weber A,Liu SL,Wah PS,Schwarz HP

    更新日期:2007-01-01 00:00:00

  • A new platelet-specific alloantigen Bra. Report of 4 cases with neonatal alloimmune thrombocytopenia.

    abstract::Sera obtained from 4 mothers of children with neonatal alloimmune thrombocytopenia contained a platelet-specific alloantibody, anti-Bra, which defined an antigen apparently different from all known platelet alloantigens. All 4 fathers were Bra positive, whereas all mothers were Bra negative. The minimal postnatal valu...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1988.tb01625.x

    authors: Kiefel V,Santoso S,Katzmann B,Mueller-Eckhardt C

    更新日期:1988-01-01 00:00:00

  • Evaluation of a universal point-of-issue assay for bacterial detection in buffy coat platelet components.

    abstract::Bacterial contamination of platelet concentrates poses a major post-transfusion infectious risk. This study was aimed at evaluating the efficacy of the BacTx(®) assay (Immunetics Inc.) for bacterial detection in leucocyte-reduced buffy coat platelet pools and for its sensitivity in detecting clinical isolates, includi...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12148

    authors: Ramirez-Arcos S,Kou Y,Perkins H

    更新日期:2014-08-01 00:00:00

  • Study of the immunopotentiator effects of dialyzable leukocyte extracts obtained out of leukocytes previously used for interferon production.

    abstract::The existence of immunopotentiator factors able to induce blastogenesis, chemotaxis and able of inhibiting migration of leukocytes was investigated in alcohol precipitates of different batches of dialyzed leukocyte extracts (DLE). These were prepared either out of fresh leukocytes from a large pool of buffy coats obta...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1982.tb00018.x

    authors: Arala-Chaves MP,Porto MT,Kauppinen HL,Massa AA,Myllylä G

    更新日期:1982-11-01 00:00:00

  • Parallel comparison of apheresis-collected platelet concentrates stored in four different additive solutions.

    abstract:BACKGROUND AND OBJECTIVES:Partially replacing plasma with additive solutions in platelet (PLT) concentrates (PCs) may help to reduce transfusion reactions. Constituents of PLT additive solutions (PASs) have been revealed to affect the quality of PCs. Previous studies involved pairwise comparison of identical PLTs with ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12064

    authors: Nogawa M,Naito Y,Chatani M,Onodera H,Shiba M,Okazaki H,Matsuzaki K,Satake M,Nakajima K,Tadokoro K

    更新日期:2013-11-01 00:00:00

  • Assessment of methods for cytomegalovirus antibody testing of blood donations.

    abstract::As part of a programme to establish a panel of individuals with high titres of anticytomegalovirus (CMV) IgG for the production of CMV Ig, the CMV serostatus of 139 normal blood donors was determined by indirect haemagglutination assay, enzyme immunoassay, and complement fixation. The indirect haemagglutination assay ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb04137.x

    authors: Chung A,Chang W,Leung MK,Ofosu FA,Moore BP

    更新日期:1984-01-01 00:00:00

  • Reduced immune phagocytosis of monocytes from neonates whose mothers produce HLA antibodies.

    abstract::In vivo immune phagocytosis of neonatal monocytes was significantly correlated to the extent of maternal HLA immunization. Monocytes from all 15 neonates of mothers with HLA antibodies show reduced immune phagocytosis. In contrast, this holds true for monocytes from only 6 out of 13 neonates of mothers without detecta...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1988.tb03896.x

    authors: Neppert J,Mueller-Eckhardt G,Heine O

    更新日期:1988-01-01 00:00:00

  • Editorial: Red cell ageing and death.

    abstract::To obtain red cell populations of increasing mean age erythropoiesis was arrested through continuous actinomycin treatment or maintained transfusion polycythemia in mice and rats respectively. The parameters studied included cell indices, enzyme activities and rheological characteristics. Further, the life-span of age...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb02809.x

    authors: Ganzoni AM,Barras JP,Marti HR

    更新日期:1976-01-01 00:00:00

  • Cytomegalovirus (CMV) antibody in male homosexuals: a source for CMV immune globulin.

    abstract::Male homosexuals have been found to have an extraordinarily high prevalence, and high titers, of antibodies to cytomegalovirus (CMV), as determined by complement-fixation and passive hemagglutination tests. These findings support other data suggesting that CMV may be sexually transmitted. The high titers of CMV antibo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1983.tb01881.x

    authors: Ikram H,Prince AM,Baker LN

    更新日期:1983-03-01 00:00:00

  • Determinants of transfusion decisions in the ICU: haemoglobin concentration, what else? - a retrospective cohort study.

    abstract:BACKGROUND AND OBJECTIVES:The aim of this study was to assess potentially relevant clinical characteristics which influence the decision to transfuse red cells in critically ill patients with low haemoglobin concentrations (6.0-10.0 g/dl). MATERIALS AND METHODS:This was a retrospective observational cohort study of pa...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12831

    authors: Kranenburg FJ,le Cessie S,Caram-Deelder C,van der Bom JG,Arbous MS

    更新日期:2019-11-01 00:00:00

  • Red cell transfusion practice following the transfusion requirements in critical care (TRICC) study: prospective observational cohort study in a large UK intensive care unit.

    abstract:BACKGROUND AND OBJECTIVES:The Transfusion Requirements In Critical Care (TRICC) study found that critically ill patients tolerate a restrictive haemoglobin transfusion threshold. We investigated red-cell transfusion practice since publication of the TRICC study in a large Scottish teaching hospital intensive care unit ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2003.00284.x

    authors: Chohan SS,McArdle F,McClelland DB,Mackenzie SJ,Walsh TS

    更新日期:2003-04-01 00:00:00

  • Influence of granulocyte antibodies on granulocyte function.

    abstract::The following substances were tested for their influence on granulocyte function: 8 sera that contained human granulocyte-specific alloantibodies against the antigens NA1, NA2 and NB1, two HLA antisera, and the monoclonal antibodies W6/32 and CLB-FcR-gran 1. The effects examined included spontaneous and directed migra...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1993.tb03059.x

    authors: Bux J,Dickmann JO,Stockert U,Mueller-Eckhardt C

    更新日期:1993-01-01 00:00:00

  • Hemostasis testing during massive blood replacement. A study of 172 cases.

    abstract::A 24-hours service was organized to study changes in the hemostatic system in surgical patients undergoing massive transfusion for excessive bleeding during operation or in the early postoperative period. Hemostasis tests gave normal results in only 12(7%) of the 172 patients, while in the remaining 160(93%) one or mo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1982.tb01080.x

    authors: Mannucci PM,Federici AB,Sirchia G

    更新日期:1982-03-01 00:00:00

  • Sensitivity of assays for the detection of HPA-1a antibodies: results of an international workshop demonstrating the impact of cation chelation from integrin αIIbβ3 on three widely used assays.

    abstract:BACKGROUND AND OBJECTIVES:HPA-1a antibodies account for 70-80% of cases of fetal-neonatal alloimmune thrombocytopenia (FNAIT) in Caucasians. However, numerous workshops have demonstrated variability in their detection. We recently showed that exposure of αIIbβ3 to ethylene diamine tetraacetic acid (EDTA) affected bindi...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12043

    authors: Allen DL,Metcalfe P,Kaplan C,Kekomaki R,de Haas M,Yusuf R,Ouwehand WH

    更新日期:2013-08-01 00:00:00

  • Placental transfer of Rh antibody (anti-D IgG) during pregnancy.

    abstract::Anti-D levels in blood taken immediately postpartum from Rh-negative women who have been given antenatal Rh immune globulin and the anti-D levels in the cord blood of their babies were measured semiquantitatively by a low ionic polybrene Auto Analyzer technique. When both mother and baby were Rh-negative a comparison ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1982.tb00031.x

    authors: Pollock JM,Bowman JM

    更新日期:1982-01-01 00:00:00

  • Cytokines in platelet concentrates prepared from pooled buffy coats.

    abstract::Platelet concentrates (PC) prepared from pooled buffy coat (BC-PC) contain a variable number of leukocytes from different donors. We questioned whether storage of BC-PC can lead to a lymphocyte activation in the sense of a mixed lymphocyte reaction. BC-PC were prepared from four ABO-identical buffy coats and we undert...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1995.tb00345.x

    authors: Klüter H,Müller-Steinhardt M,Danzer S,Wilhelm D,Kirchner H

    更新日期:1995-01-01 00:00:00

  • Estimation of the number of binding sites for a murine monoclonal anti-Lub on human erythrocytes.

    abstract::The number of Lub antigen sites on the human erythrocyte membrane, as recognised by the murine monoclonal antibody BRIC-108, has been determined. The number of antibody molecules bound per cell on one example of cells of the phenotype Lu(a-b-) with recessive inheritance was an average of around 200 in replicate determ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1987.tb04915.x

    authors: Merry AH,Gardner B,Parsons SF,Anstee DJ

    更新日期:1987-01-01 00:00:00

  • TRALI is due to pulmonary venule damage from leucocytes with cholesterol crystal formation.

    abstract:BACKGROUND:There are two presumed mechanisms for the pulmonary oedema in transfusion-related acute lung injury (TRALI). One is antibodies to leucocytes while the other is biologically active lipids. We evaluated the vascular injury due to the former. METHODS:The pulmonary vasculature was studied by light microscopy (L...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2009.01235.x

    authors: Jensen HM,Galante JM,Kysar PE,Tolstikov VV,Reddy KJ,Holland PV

    更新日期:2010-02-01 00:00:00

  • Proposal for the nomenclature of human plasminogen (PLG) polymorphism.

    abstract::Since its discovery, human plasminogen (PLG) polymorphism has received widespread acceptance in population genetics and forensic haematology. Due to the large number of variant alleles described, a PLG reference typing and Plasminogen Symposium was held, at which a nomenclature proposal was inaugurated. The technology...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb01963.x

    authors: Skoda U,Bertrams J,Dykes D,Eiberg H,Hobart M,Hummel K,Kühnl P,Mauff G,Nakamura S,Nishimukai H

    更新日期:1986-01-01 00:00:00

  • The ABCB6 mutation p.Arg192Trp is a recessive mutation causing the Lan- blood type.

    abstract:BACKGROUND AND OBJECTIVE:The membrane transporter ABCB6 has recently been shown to carry the high-frequency red-blood-cell (RBC) antigen Lan. All the Lan- individuals genotyped so far have inherited two recessive null mutations in ABCB6. The finding of a family with the Lan- blood type occurring in two successive gener...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2012.01650.x

    authors: Saison C,Helias V,Peyrard T,Merad L,Cartron JP,Arnaud L

    更新日期:2013-02-01 00:00:00

  • A single unit of transfused allogeneic blood increases postoperative infections.

    abstract::The aim of this prospective study was to evaluate if there was a statistical correlation between allogeneic blood transfusion and postoperative infections, and if this could have a dose-dependent pattern. The evaluation was based on multiple logistic and receiver operating characteristics (ROC) curve analyses. On hosp...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1996.7130170.x

    authors: Vignali A,Braga M,Gianotti L,Radaelli G,Gentilini O,Russo A,Di Carlo V

    更新日期:1996-01-01 00:00:00

  • Estimated risk of transmission of hepatitis C virus by blood transfusion.

    abstract:OBJECTIVE:The risk of transmitting hepatitis C (HCV) by transfusion of anti-HCV-negative screened blood was estimated for the blood donor population of Baden-Württemberg (southwestern Germany). METHODS:The data from the blood donors screened for anti-HCV and for HBsAg during 1990-1995 were analyzed. RESULTS:The preva...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Koerner K,Cardoso M,Dengler T,Kerowgan M,Kubanek B

    更新日期:1998-01-01 00:00:00

  • A multi-centre study on the performance of the molecular genotyping platform ID RHD XT for resolving serological weak RhD phenotype in routine clinical practice.

    abstract:BACKGROUND AND OBJECTIVES:There is concern regarding the lack of prevention of unnecessary transfusion of RhD negative red cells and unnecessary administration of Rh immunoglobulin (RhIG) to pregnant women. In this study, performance of ID RHD XT, a genotyping assay for identification of six RHD allelic variants and hu...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,多中心研究

    doi:10.1111/vox.12886

    authors: Londero D,Monge J,Hellberg A

    更新日期:2020-04-01 00:00:00