The effect of immunoadsorption with the Immusorba TR-350 column on coagulation compared to plasma exchange.

Abstract:

BACKGROUND AND OBJECTIVES:Plasma exchange (PE) and immunoadsorption with the Immusorba TR-350 column (IA) are used to remove autoantibodies from plasma in acute neurological autoimmune disorders. The impact of IA on coagulation and on low molecular weight heparin (LMWH) levels in comparison with PE was investigated. PATIENTS AND METHODS:In five patients with neurological autoimmune disorders, coagulation parameters (global tests, coagulation factors) were measured before and after PE or IA (Part A). In five other patients under anticoagulation with LMWH, anti-Xa activity and global tests were measured before and after the treatments (Part B). RESULTS:After PE, coagulation factors were significantly reduced by 50-70%. After IA, a distinct reduction was observed for fibrinogen, but not for antithrombin and most of the other coagulation factors. Anti-Xa activity was reduced after PE (from 0.57 ± 0·10 to 0.13 ± 0.05 IU/ml) and almost unchanged after IA. CONCLUSION:It is advisable to discontinue or to reduce LMWH doses and to monitor coagulation parameters and anti-Xa activity after PE or IA to decide about further LMWH dosing.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Koessler J,Kobsar A,Kuhn S,Koessler A,Yilmaz P,Weinig E,Putz E,Boeck M,Klinker E

doi

10.1111/vox.12191

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

46-51

issue

1

eissn

0042-9007

issn

1423-0410

journal_volume

108

pub_type

杂志文章
  • Effect of beta-propiolactone on blood group antibody detection.

    abstract::A panel of 50 blood group antibodies covering a range of blood group antigens has been tested in the presence of 0.25% beta-propiolactone as a possible means of reducing infectivity of high-risk HTLV III/HBsAg samples. 11/50 (22%) antibodies could not be detected by the indirect antiglobulin test, and 6/40 (15%) were ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1986.tb00207.x

    authors: Hunt AF,Jones MT,Howkins GJ

    更新日期:1986-01-01 00:00:00

  • Use of the MAIEA technique to confirm the relationship between the Cromer antigens and decay-accelerating factor and to assign provisionally antigens to the short-consensus repeats.

    abstract::The MAIEA (monoclonal-antibody-specific immobilisation of erythrocyte antigens) assay has recently been developed for the assignment of red cell antigens, recognised by human alloantisera, to particular membrane components of the red cell membrane. This technique detects trimolecular complexes formed by the reaction o...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1993.tb02172.x

    authors: Petty AC,Daniels GL,Anstee DJ,Tippett P

    更新日期:1993-01-01 00:00:00

  • Transfusion results of filtered and subsequently stored random platelet suspensions prepared from buffy coats.

    abstract::There is almost general agreement that removal of leukocytes from blood components reduces the incidence of HLA-antibody formation and refractoriness to random platelet transfusions. Recently filters have become available, which are able to reduce leukocyte contamination in platelet suspensions with acceptable platele...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1992.tb01214.x

    authors: Novotny VM,van Doorn R,Rozier Y,D'Amaro J,Harvey MS,Brand A

    更新日期:1992-01-01 00:00:00

  • Molecular genetic analysis of para-Bombay phenotypes in Chinese: a novel non-functional FUT1 allele is identified.

    abstract:BACKGROUND AND OBJECTIVES:The para-Bombay phenotype (also known as H-deficient secretor) is characterized by a lack of ABH antigens on red cells, but ABH substances are found in saliva. Molecular genetic analysis was performed for five Chinese individuals serologically typed as para-Bombay. MATERIALS AND METHODS:ABO g...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2002.00184.x

    authors: Yip SP,Chee KY,Chan PY,Chow EY,Wong HF

    更新日期:2002-10-01 00:00:00

  • Screening plasma donors for high-titre antibody to cytomegalovirus using a latex agglutination test.

    abstract::Cytomegalovirus (CMV) can cause severe morbidity in immunosuppressed patients. Regional transfusion centres in the UK are required to supply high-titre anti-CMV plasma to the Blood Products Laboratory (BPL), now called 'Bio-Products Laboratory', for the production of specific intravenous immunoglobulin at the Protein ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1990.tb05014.x

    authors: McDonald C,Barbara JA,al-Izzi A,Contreras M

    更新日期:1990-01-01 00:00:00

  • Blood transfusion in sickle cell disease.

    abstract::Blood transfusion is used as a life-saving and prophylactic treatment in sickle cell disease. Despite the many complications associated with its use, few randomised controlled trials and careful research studies have been performed to fully define its role. This subjects is, therefore, discussed in the context of the ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1995.tb03916.x

    authors: Davies SC,Olatunji PO

    更新日期:1995-01-01 00:00:00

  • Activity of B-gene-specified galactosyltransferase in individuals with Bm phenotypes.

    abstract::Blood group B-gene-specified alpha-galactosyltransferase was determined in serums and erythrocyte membranes of several related persons with Bm phenotypes. The level of this enzyme in serums was similar to, but in erythrocyte membranes much lower than that found in normal B and AB persons. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb04834.x

    authors: Kościelak J,Pacuszka T,Dzierzkowa-Borodej W

    更新日期:1976-01-01 00:00:00

  • The influence of platelet glycoprotein polymorphisms on receptor function and risk for thrombosis.

    abstract::With regard to hemostasis and thrombosis, collagens are among the most important physiologic components of the extracellular matrix in their role as platelet activators. Differences in the rate of platelet activation markedly influence normal hemostasis and the pathological outcome of thrombosis. Thus, collagen recept...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.2002.tb05274.x

    authors: Kunicki TJ,Nugent DJ

    更新日期:2002-08-01 00:00:00

  • Evaluation of a new microporous filtration membrane system for therapeutic plasma exchange.

    abstract::A new therapeutic plasma exchange device developed by Sarns Inc./3M was evaluated in plasmapheresis of 20 healthy volunteers and in a multicenter clinical study of therapeutic plasma exchange that included 49 patients. Safety and efficacy of plasma separation from whole blood were assessed for a module that contains D...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1987.tb04925.x

    authors: Kurtz SR,Carey PM,McGill M,Pineda AA,Zaroulis CG,Case MT

    更新日期:1987-01-01 00:00:00

  • Effect of heat on stored red cells during non-flow conditions in a blood-warming device.

    abstract:BACKGROUND AND OBJECTIVES:While blood is flowing within a transfusion-warming device, the blood temperature is usually less than that applied externally. If the flow is temporarily stopped, the temperature can rise above 37 degrees C in some warming devices. We sought to determine whether temperatures near 45 degrees C...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1159/000031054

    authors: Eastlund T,Van Duren A,Clay ME

    更新日期:1999-01-01 00:00:00

  • Factors related to allergic transfusion reactions and febrile non-haemolytic transfusion reactions in children.

    abstract:BACKGROUND AND OBJECTIVES:Allergic transfusion reactions (ATRs) and febrile non-haemolytic transfusion reactions (FNHTRs) are the two major types of transfusion-related adverse reactions (TRARs). Although prestorage leucocyte reduction and diversion of the first aliquot of blood (LR/D) could reduce FNHTRs and bacterial...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12373

    authors: Yanagisawa R,Shimodaira S,Sakashita K,Hidaka Y,Kojima S,Nishijima F,Hidaka E,Shiohara M,Nakamura T

    更新日期:2016-05-01 00:00:00

  • Red blood cell utilization and transfusion triggers in patients diagnosed with chronic lymphocytic leukaemia in Iceland 2003-2016.

    abstract:BACKGROUND AND OBJECTIVES:Revised Icelandic guidelines proposed a restrictive haemoglobin (Hb) threshold of 70 g/l for red blood cell (RBC) transfusions in general, but 100 g/l for malignancies/bone marrow suppression. Chronic lymphocytic leukaemia (CLL) is frequently complicated by anaemia. The objective was to invest...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12775

    authors: Thorvaldsson HH,Vidarsson B,Sveinsdottir SV,Olafsson GB,Halldorsdottir AM

    更新日期:2019-07-01 00:00:00

  • Acute hypoproteinemic fluid overload: its determinants, distribution, and treatment with concentrated albumin and diuretics.

    abstract::We simulated the use of massive volumes of crystalloid fluids as a treatment of acute plasma loss in a standardized experimental model and studied the factors determining the retention or excretion of the resulting acute hypoproteinemic fluid overload, its distribution within the body, and its treatment with concentra...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1977.tb04481.x

    authors: Pappova E,Bachmeier W,Crevoisier JL,Kollar J,Kollar M,Tobler P,Zahler HW,Zaugg D,Lundsgaard-Hansen P

    更新日期:1977-01-01 00:00:00

  • Transmission of parasites and bacteria by blood components.

    abstract:BACKGROUND AND OBJECTIVES:Although most attention has been paid to viral infections as a complication of transfusion, some parasitic infections are readily transmissible and generate a heavy burden of disease, particularly in the developing world. Additionally, bacterial infection as a result of transfusion is the most...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:

    authors: Dodd RY

    更新日期:2000-01-01 00:00:00

  • Inactivation of hepatitis A virus by pasteurization and elimination of picornaviruses during manufacture of factor VIII concentrate.

    abstract::Hepatitis A virus (HAV) infections have been reported among hemophiliacs who received factor VIII concentrates which had been purified by ion-exchange chromatography and treated by the solvent detergent (SD) method. Since the virus inactivation procedure of our manufacturing process is heat treatment of the stabilized...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:

    authors: Hilfenhaus J,Nowak T

    更新日期:1994-01-01 00:00:00

  • Improvement of enzyme-linked antiglobulin test by using an antiglobulin linked to glucose oxidase: description of the technique.

    abstract::The classic enzyme-linked antiglobulin test (ELAT) used to detect and quantify the amount of IgG antibodies on red blood cells (RBC) is sensitive to hemolysis and erythrocyte enzymatic activities. We describe a new ELAT by using glucose oxidase (GO) linked to antihuman IgG. The optical density base line of GO-ELAT, al...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb00098.x

    authors: Rigal D,Monestier M,Lafont S,Raffin T,Got A,Meyer F,Jouvenceaux A

    更新日期:1984-01-01 00:00:00

  • Reticulocyte count in red-blood-cell units stored in AS-1.

    abstract:BACKGROUND AND OBJECTIVES:Previous data that showed maintenance of reticulocyte percentage in whole blood stored in CPDA-1 have led to the assumption that reticulocyte maturation becomes arrested during refrigerated storage. However, reticulocyte behaviour in red-blood-cell units stored in additive solutions has not ye...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12011

    authors: Urbina A,Palomino F

    更新日期:2013-05-01 00:00:00

  • Red-blood-cell alloimmunization and prophylactic antigen matching for transfusion in patients with warm autoantibodies.

    abstract:BACKGROUND:Warm autoantibodies (WAA) are antibodies that react with an antigen on a patient's own red-blood-cells and can complicate compatibility testing whether or not they cause clinical haemolysis. The goal of this study was to understand the overall prevalence of WAA, the risk of RBC alloimmunization and determine...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12914

    authors: Delaney M,Apelseth TO,Bonet Bub C,Cohn CS,Dunbar NM,Mauro Kutner J,Murphy M,Perelman I,Selleng K,Staves J,Wendel S,Ziman A,Biomedical Excellence for Safer Transfusion (BEST) Collaborative.

    更新日期:2020-08-01 00:00:00

  • Unusual serological response to hepatitis E virus in plasma donors consistent with re-infection.

    abstract::Hepatitis E virus (HEV)-positive plasma donations, identified by a plasma mini-pool screening approach, were analysed using serological methods for the presence of anti-HEV IgM and IgG. Avidity testing was performed on the IgG-reactive donations. Anti-HEV IgG with high avidity was observed in two donors together with ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12294

    authors: Baylis SA,Crossan C,Corman VM,Blümel J,Scobie L,Dalton HR

    更新日期:2015-11-01 00:00:00

  • An autoantibody with activity dependent on red cell age in the serum of a patient with autoimmune haemolytic anaemia and a negative direct antiglobulin test.

    abstract::A red cell IgM autoantibody with anti-e specificity was identified in the serum of a rhesus-negative (rr) patient presenting with haemolytic anaemia and a negative direct antiglobulin test. The autoantibody strongly agglutinated normal allogeneic rhesus-negative (rr) red cells in saline at 37 degrees C but had only we...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1987.tb02993.x

    authors: Herron R,Clark M,Smith DS

    更新日期:1987-01-01 00:00:00

  • Transferrin binding by peripheral blood mononuclear cells in human lymphomas, myelomas and leukemias.

    abstract::Significantly more peripheral blood mononuclear cells (PBM) from 39 patients with lymphoma (p less than 0.001), myeloma (p less than 0.001), or leukemia (p less than 0.001-0.025) bind transferrin (Trf) than those of 23 normals. That Trf was bound to a receptor on these cells was shown by the inhibition of these cells ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1984.tb00078.x

    authors: Yeh CJ,Taylor CG,Faulk WP

    更新日期:1984-01-01 00:00:00

  • Identification of a novel A2 allele derived from the A transferase gene through a nucleotide substitution G539C.

    abstract:BACKGROUND AND OBJECTIVES:The A2 is a very rare phenotype in the ABO blood group system in the Oriental population. It corresponds to a special ABO allele encoding a glycosyltransferase that is capable of synthesizing A2 antigens, which is weaker than the typical A antigen. In this study, we report a novel A2 allele in...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2005.00608.x

    authors: Chen DP,Tseng CP,Wang WT,Sun CF

    更新日期:2005-04-01 00:00:00

  • A multicentre evaluation of a new filtration protocol for leucocyte depletion of high-haematocrit red blood cells collected by an automated blood collection system.

    abstract:BACKGROUND AND OBJECTIVES:A multicentre trial was set up to evaluate the performance of a new leucodepletion protocol. MATERIALS AND METHODS:Filtration at high haematocrit was started during collection of red blood cell (RBC) products by apheresis with Trima. SAG-M was added after filtration through the filter. Haemat...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1046/j.1423-0410.2001.00078.x

    authors: Soli M,Blanco L,Riggert J,Martínez-Clavel A,Lucas C,Lunghi M,Belloni M,Wolf C,van Waeg G,Antoon M

    更新日期:2001-01-01 00:00:00

  • Prospective study of posttransfusion hepatitis in cardiac surgery patients receiving only blood or also blood products.

    abstract::The incidence, etiology and risk factors of posttransfusion (PT) hepatitis were evaluated in a prospective study of 297 consecutive open-heart surgery patients. PT hepatitis occurred in 63 (21.2%) patients with a significantly higher hepatitis attack rate in 51 recipients of commercial clotting factor concentrates (56...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1983.tb04099.x

    authors: Tremolada F,Chiappetta F,Noventa F,Valfrè C,Ongaro G,Realdi G

    更新日期:1983-01-01 00:00:00

  • Efficacy of heat treatment of factor VIII concentrate.

    abstract::Two batches of heat-treated factor VIII concentrate were found to contain anti-HIV-positive plasma donations. The batches were dry-heat-treated at 68 degrees C for 2 and 24 h, respectively. No HIV seroconversions occurred in 13 susceptible haemophiliacs receiving a total of 540 bottles of these factor VIII preparation...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1988.tb03904.x

    authors: Cuthbert RJ,Ludlam CA,Brookes E,McClelland DB

    更新日期:1988-01-01 00:00:00

  • Identification of kallikrein and FXIa as impurities in therapeutic immunoglobulins: implications for the safety and control of intravenous blood products.

    abstract:BACKGROUND AND OBJECTIVES:The occurrence of thromboembolic events (TEEs) with intravenous immunoglobulin lots (IVIGs) raised the question of the causative agent for these adverse events. We investigated the predominant plasma proteases in 19 IVIG lots from five manufacturers including three lots associated with adverse...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2011.01502.x

    authors: Etscheid M,Breitner-Ruddock S,Gross S,Hunfeld A,Seitz R,Dodt J

    更新日期:2012-01-01 00:00:00

  • A Swiss family showing independent segregation of the Lutheran and Swann genes.

    abstract::A family is reported in which the parents' mating is of the 'double back-cross' type with respect to the Sw, Lu and Se genes. The inheritance of these genes in the children shows, with reference to a possible linkage between Sw and the two other loci, four non-recombinants and three recombinants (or vice versa). The i...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb02221.x

    authors: Metaxas MN,Metaxas-Buehler M

    更新日期:1976-01-01 00:00:00

  • Transfusion-related inhibition of cytokines (TRICK). Experimental transfer of neutralizing autoantibodies to interleukin-6 by plasma transfusions.

    abstract:BACKGROUND:For some unknown reason humans may 'spontaneously' produce high amounts of neutralizing autoantibodies to a number of growth factors and cytokines. Reaching a certain high level the antibodies render the person cytokine deficient, mostly without overt clinical manifestations. The autoantibodies in question a...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1423-0410.2006.00881.x

    authors: Hansen MB,Galle P,Salomo M,Svenson M,Dickmeiss E,Gimsing P

    更新日期:2007-04-01 00:00:00

  • Analbuminemia: report of a case and review of the literature.

    abstract::Idiopathic analbuminemia was fortuitously detected in a 30-year-old Italian woman. No associated disease condition could be revealed in this patient, the only consistent finding being a slight tendency to develop ankle edema. Asthenia and a moderate hypotension were also recorded. Trace amounts (5.2 mg/100 ml) of seru...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1980.tb01851.x

    authors: Dammacco F,Miglietta A,D'Addabbo A,Fratello A,Moschetta R,Bonomo L

    更新日期:1980-09-01 00:00:00

  • Safety of leucodepleted salvaged blood in oncological surgery: an in vitro model.

    abstract::Intra-operative blood cell salvage (IOCS) is mainly avoided in onco surgery due to the suspicion that it could increase metastasis' risk. We simulated IOCS followed by leucodepletion: HCT116 (human colorectal cancer) cells were inoculated into packed red blood cells units, and their distribution was evaluated, step-by...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12565

    authors: Marraccini C,Merolle L,Berni P,Boito K,Tamagnini I,Kuhn E,Ragazzi M,Baricchi R,Pertinhez TA

    更新日期:2017-11-01 00:00:00