Blood transfusion in sickle cell disease.


:Blood transfusion is used as a life-saving and prophylactic treatment in sickle cell disease. Despite the many complications associated with its use, few randomised controlled trials and careful research studies have been performed to fully define its role. This subjects is, therefore, discussed in the context of the current literature and authors' experience.


Vox Sang


Vox sanguinis


Davies SC,Olatunji PO




Has Abstract


1995-01-01 00:00:00












  • Rare and transient anti-D antibody response in D(-) liver transplant recipients transfused with D(+) red blood cells.

    abstract::A retrospective analysis was conducted on 20 D(-) liver transplant (LT) recipients transfused with D(+) RBCs perioperatively and screened for RBC antibodies between 2 and 6 months later. None developed anti-D detectable by the indirect antiglobulin test. Two patients produced weak anti-D that reacted only with papain-...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Burin des Roziers N,Ibanez C,Samuel D,Francoz C,Idri S,François A,Mortelecque R,Bierling P,Pirenne F

    更新日期:2016-07-01 00:00:00

  • Prospective evaluation of immune haemolysis in liver transplantation.

    abstract:BACKGROUND:Immune haemolysis in liver transplant (LT) can occur due to autoantibodies and alloantibodies. The aim of this study was to evaluate the prevalence and risk factors for immune haemolysis in LT. METHODS:A total of 175 consecutive patients were included. Multiorgan recipients were excluded. Samples, from befo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Brunetta DM,de Barros Carlos LM,Da Silva VFP,de Oliveira Alves TM,Macedo ÊS,Coelho GR,Vasconcelos JBM,De Francesco Daher E,Garcia JHP

    更新日期:2020-01-01 00:00:00

  • An analysis of autologous blood donor motivational factors.

    abstract::Little is known about the patient's reasons for participating in an autologous blood (AUB) collection program. We surveyed 110 AUB donors in our hospital-based collection program. Although fear of infection from an allogeneic blood transfusion was cited by 20% of AUB donors, 68.2% indicated that their physician's reco...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Domen RE,Ribicki LA,Hoeltge GA

    更新日期:1995-01-01 00:00:00

  • The Sdx antigen and antibody: biochemical studies on the inhibitory property of human urine.

    abstract::Anti-Sdx is an IgM complement-binding autoantibody that defines a red cell antigen which is independent of I, i, Sp1 (Pr) and Gd. Hemagglutination by the antibody is unusually sensitive to variation in pH, salt, or other charged molecular species. The antibody is inhibited by urine from Sd(a+) persons, but inhibition ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Bass LS,Rao AH,Goldstein J,Marsh WL

    更新日期:1983-03-01 00:00:00

  • An autoantibody with activity dependent on red cell age in the serum of a patient with autoimmune haemolytic anaemia and a negative direct antiglobulin test.

    abstract::A red cell IgM autoantibody with anti-e specificity was identified in the serum of a rhesus-negative (rr) patient presenting with haemolytic anaemia and a negative direct antiglobulin test. The autoantibody strongly agglutinated normal allogeneic rhesus-negative (rr) red cells in saline at 37 degrees C but had only we...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Herron R,Clark M,Smith DS

    更新日期:1987-01-01 00:00:00

  • Identification of kallikrein and FXIa as impurities in therapeutic immunoglobulins: implications for the safety and control of intravenous blood products.

    abstract:BACKGROUND AND OBJECTIVES:The occurrence of thromboembolic events (TEEs) with intravenous immunoglobulin lots (IVIGs) raised the question of the causative agent for these adverse events. We investigated the predominant plasma proteases in 19 IVIG lots from five manufacturers including three lots associated with adverse...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Etscheid M,Breitner-Ruddock S,Gross S,Hunfeld A,Seitz R,Dodt J

    更新日期:2012-01-01 00:00:00

  • Collaborative study to establish a replacement World Health Organization International Standard for parvovirus B19 DNA nucleic acid amplification technology (NAT)-based assays.

    abstract:BACKGROUND AND OBJECTIVES:The aim of the study was to replace the 1(st) World Health Organization International Standard for parvovirus B19 DNA for nucleic acid amplification technique (NAT)-based assays (code 99/800). Two lyophilized preparations (coded 99/800 and 99/802) had been evaluated in the original collaborati...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,多中心研究


    authors: Baylis SA,Chudy M,Blümel J,Pisani G,Candotti D,José M,Heath AB

    更新日期:2010-04-01 00:00:00

  • Photosensitized inactivation of Plasmodium falciparum- and Babesia divergens-infected erythrocytes in whole blood by lipophilic pheophorbide derivatives.

    abstract:BACKGROUND AND OBJECTIVES:Blood transfusions can transmit parasitic infections, such as those caused by Plasmodium (malaria), Trypanosoma cruzi (Chagas' disease), and Babesia (babesiosis). A higher degree of blood transfusion safety would be reached if methods were available for inactivating such parasites. MATERIALS ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Grellier P,Santus R,Mouray E,Agmon V,Mazière JC,Rigomier D,Dagan A,Gatt S,Schrével J

    更新日期:1997-01-01 00:00:00

  • Brb, a platelet alloantigen involved in neonatal alloimmune thrombocytopenia.

    abstract::Serum from a pregnant woman with the May-Hegglin anomaly contained a platelet-specific antibody. The serum reacted in the platelet indirect immunofluorescence test (PIIFT) with 97.6% of random donor platelets and those of the father but not with the mother's own platelets. This antibody induced a moderate thrombocytop...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Bettaieb A,Fromont P,Rodet M,Godeau B,Duedari N,Bierling P

    更新日期:1991-01-01 00:00:00

  • A family with allo-immune neonatal neutropenia: group-specific pathogenicity of maternal antibodies.

    abstract::A family is presented, in which the mother developed strong neutrophil granulocyte-specific antibodies with the specificity anti-NA. The first and third children, both NA1-positive, suffered from severe transient neonatal neutropenia, but the second child, NA1-negative, did not. Anti-NA1 antibodies were detectable in ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Verheugt FW,van Noord-Bokhorst JC,von dem Borne AE,Engelfriet CP

    更新日期:1979-01-01 00:00:00

  • Post-thaw viable CD34(+) cell count is a valuable predictor of haematopoietic stem cell engraftment in autologous peripheral blood stem cell transplantation.

    abstract:BACKGROUND AND OBJECTIVES:In peripheral blood stem cell transplantation, the number of CD34(+) cells infused is considered a predictor of haematopoietic engraftment. However, the currently accepted minimal threshold of CD34(+) cells/kg was determined by counting CD34(+) cells before freezing, and the loss of viable CD3...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Lee S,Kim S,Kim H,Baek EJ,Jin H,Kim J,Kim HO

    更新日期:2008-02-01 00:00:00

  • Evaluation of a universal point-of-issue assay for bacterial detection in buffy coat platelet components.

    abstract::Bacterial contamination of platelet concentrates poses a major post-transfusion infectious risk. This study was aimed at evaluating the efficacy of the BacTx(®) assay (Immunetics Inc.) for bacterial detection in leucocyte-reduced buffy coat platelet pools and for its sensitivity in detecting clinical isolates, includi...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Ramirez-Arcos S,Kou Y,Perkins H

    更新日期:2014-08-01 00:00:00

  • Inefficacy of plasma exchange in cold agglutinin hemolytic anemia--a case study.

    abstract::A therapeutic trial of plasma exchange was conducted in an 82-year-old woman with severe cold agglutinin hemolytic anemia, who was unresponsive to conventional treatment. In spite of considerable improvement of pertinent parameters (total IgM, cold agglutinin titer and thermal amplitude) this treatment failed to induc...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Rodenhuis S,Maas A,Hazenberg CA,Das PC,Nieweg HO

    更新日期:1985-01-01 00:00:00

  • Flow cytometry: a tool in immunohematology for D+W (Du) antigen evaluation?

    abstract::We performed a flow-cytometric analysis of the expression of D antigen in D+W samples (previously termed Du). We also analysed a series of D-positive and D-negative (cde phenotype) samples to obtain positive and negative controls, respectively. The evaluation was carried out by immunofluorescence and the intensity of ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Tazzari PL,Bontadini A,Belletti D,Malferrari F,Conte R

    更新日期:1994-01-01 00:00:00

  • The influence of platelet glycoprotein polymorphisms on receptor function and risk for thrombosis.

    abstract::With regard to hemostasis and thrombosis, collagens are among the most important physiologic components of the extracellular matrix in their role as platelet activators. Differences in the rate of platelet activation markedly influence normal hemostasis and the pathological outcome of thrombosis. Thus, collagen recept...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审


    authors: Kunicki TJ,Nugent DJ

    更新日期:2002-08-01 00:00:00

  • Platelet-rich plasma and platelet gel preparation using Plateltex.

    abstract:BACKGROUND:The platelet gel is made by embedding concentrate platelets within a semisolid (gel) network of polymerized fibrin. It is believed that this blood component will be used more and more in the treatment of several clinical conditions and as an adjunctive material in tissue engineering. Several systems are avai...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Mazzucco L,Balbo V,Cattana E,Borzini P

    更新日期:2008-04-01 00:00:00

  • Human T-cell lymphotropic virus: A simulation model to estimate residual risk with universal leucoreduction and testing strategies in Canada.

    abstract:BACKGROUND AND OBJECTIVES:In Canada, transfusion transmission risk of Human T-cell lymphotropic virus -I/II (HTLV) is addressed by universal leucoreduction and universal antibody testing. We aimed to estimate the risk with the current policy, if testing only first-time donors and if testing were stopped. MATERIALS AND...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: O'Brien SF,Yi QL,Goldman M,Grégoire Y,Delage G

    更新日期:2018-11-01 00:00:00

  • A study of IgE in immunoglobulin preparations for intravenous administration. I. IgE in intravenous IgG.

    abstract::We have studied the IgE content of different lots of commercial intravenous IgG preparations used in our day hospital as replacement therapy for patients with agammaglobulinemia. Two enzymatic methods were used: Phadezym and FAST. The average amounts of IgE detected in Endobulin and Sandoglobulin lots were very high w...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Paganelli R,Quinti I,D'Offizi GP,Papetti C,Cabello A,Aiuti F

    更新日期:1986-01-01 00:00:00

  • Removal of hepatitis B virus infectivity from human gamma-globulin prepared by ion-exchange chromatography.

    abstract::Hepatitis B virus infectivity can be removed from human plasma used to prepare a gamma-globulin product by ion-exchange chromatography with commercially available resins. A pooled human plasma sample free of hepatitis markers was contaminated with 10,000 chimpanzee infectious doses of hepatitis B virus per milliliter ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Zolton RP,Padvelskis JV,Kaplan PM

    更新日期:1985-01-01 00:00:00

  • Association of ABO gene mutations resulting in a rare B subgroup.

    abstract:BACKGROUND AND OBJECTIVES:B subgroups are rare and the genetic analysis reported to date has been limited. MATERIALS AND METHODS:Serological and molecular investigations were performed in blood from a B-subgroup donor. RESULTS:Red cells did not react with anti-B and anti-AB reagents. However, cells absorbed anti-B. R...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Sousa N,Anicchino-Bizzacchi JM,Leite EM,Locatelli MF,Albuquerque D,Costa FF,Barjas-Castro ML

    更新日期:2005-01-01 00:00:00

  • A virally inactivated functional growth factor preparation from human platelet concentrates.

    abstract:BACKGROUND:Human platelet growth factors (HPGF) are essential for tissue regeneration and may replace fetal bovine serum (FBS) in cell therapy. No method for the manufacture of standardized virally inactivated HPGF has been developed yet. STUDY DESIGN AND METHODS:Platelet concentrates (PC) were subjected to solvent/de...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Su CY,Kuo YP,Lin YC,Huang CT,Tseng YH,Burnouf T

    更新日期:2009-08-01 00:00:00

  • Purification of human immunoglobulin G: a new approach to plasma fractionation.

    abstract:BACKGROUND AND OBJECTIVES:Currently, plasma fractionation involves multiple processing steps using established methods such as ethanol precipitation and column chromatography. The known limitations associated with conventional purification techniques, combined with strict regulations on safety and high demand for parti...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Li G,Stewart R,Conlan B,Gilbert A,Roeth P,Nair H

    更新日期:2002-11-01 00:00:00

  • Blood group ABH antigens on human cord red cells. Number of H antigenic sites and their distribution among different classes of membrane constituents.

    abstract::When the blood group H sites of cord erythrocytes obtained from newborn infants of groups O, A, B and AB were labelled specifically by incubation of the whole cells with the A1 gene dependent alpha-N-acetylgalactosaminyl transferase in the presence of UDP-N-acetyl [14C]-galactosamine, the incorporation of radioactivit...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Schenkel-Brunner H

    更新日期:1980-06-01 00:00:00

  • Microbiology, time course and clinical characteristics of infection in critically ill patients receiving packed red blood cell transfusion.

    abstract:BACKGROUND AND OBJECTIVES:Packed red blood cell transfusion has been associated with increased infection in a variety of critically ill patient populations. We evaluated the microbiology and time course of infection in transfused patients in the intensive care unit (ICU) as no data exist on these parameters. MATERIALS...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Rachoin JS,Daher R,Schorr C,Milcarek B,Parrillo JE,Gerber DR

    更新日期:2009-11-01 00:00:00

  • Successful treatment of bleeding with tranexamic acid in a series of 12 patients with immune thrombocytopenia.

    abstract:BACKGROUND AND OBJECTIVES:The clinical significance of immune thrombocytopenia (ITP) is mainly reflected by bleeding and/or bleeding risks, which, in some cases, cannot be adequately controlled by standard therapy. Tranexamic acid (TA) is increasingly used in preventing and reducing bleeding in several medical settings...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Mayer B,Salama A

    更新日期:2017-11-01 00:00:00

  • Transfusion risk associated with recent arbovirus outbreaks in French Polynesia.

    abstract:BACKGROUND AND OBJECTIVES:French Polynesia, where dengue virus (DENV) has been present for a long time, experienced two successive outbreaks of Zika (ZIKV) and chikungunya viruses (CHIKV) between 2013 and 2015. To avoid the transmission of these viruses by transfusion, nucleic acid testing (NAT) has been in place for D...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Beau F,Mallet HP,Lastère S,Broult J,Laperche S

    更新日期:2020-02-01 00:00:00

  • A 'new' allele, Kpc, at the Kell complex locus.

    abstract::Four Kp(a-b-) Japanese sisters, the product of a consanguineous mating, have otherwise normal Kell antigens. Kpc, a 'new' allele of Kpa and Kpb is the most probable background. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Yamaguchi H,Okubo Y,Seno T,Matsushita K,Daniels GL

    更新日期:1979-01-01 00:00:00

  • Second-generation anti-HCV screening in a Saudi Arabian donor population.

    abstract::The 2nd-generation anti-HCV test system was applied to a Saudi Arabian multi-ethnic donor population. When donors were stratified according to first-time donations versus repeat donations, the latter having been screened previously by a 1st-generation set of tests, it was found that in Saudi Arabian and Middle East na...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Bernvil SS,Andrews VJ,Sasich F

    更新日期:1994-01-01 00:00:00

  • Positive direct antiglobulin test due to antiphospholipid antibodies in normal healthy blood donors.

    abstract:OBJECTIVES:Positive direct antiglobulin tests (DAT) occur occasionally, without obvious cause, among normal blood donors. This is sometimes associated with a false-positive serologic test for syphilis. Positive DATs due to antiphospholipid antibodies (APAbs) are well documented in the antiphospholipid syndrome with sys...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Win N,Islam SI,Peterkin MA,Walker ID

    更新日期:1997-01-01 00:00:00

  • Unusual serological response to hepatitis E virus in plasma donors consistent with re-infection.

    abstract::Hepatitis E virus (HEV)-positive plasma donations, identified by a plasma mini-pool screening approach, were analysed using serological methods for the presence of anti-HEV IgM and IgG. Avidity testing was performed on the IgG-reactive donations. Anti-HEV IgG with high avidity was observed in two donors together with ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Baylis SA,Crossan C,Corman VM,Blümel J,Scobie L,Dalton HR

    更新日期:2015-11-01 00:00:00