Blood transfusion in sickle cell disease.


:Blood transfusion is used as a life-saving and prophylactic treatment in sickle cell disease. Despite the many complications associated with its use, few randomised controlled trials and careful research studies have been performed to fully define its role. This subjects is, therefore, discussed in the context of the current literature and authors' experience.


Vox Sang


Vox sanguinis


Davies SC,Olatunji PO




Has Abstract


1995-01-01 00:00:00












  • Lectin studies. III. A survey of phytohemagglutinins: interaction of lectins with erythrocytes of ten vertebrate species.

    abstract::Extracts of seeds from 79 plant species were tested for agglutinating and lytic activity with the red cells of ten vertebrate species (man, monkey, rabbit, rat, goat, sheep, guinea pig, horse, fowl, dog). Of these extracts, 24 were hemagglutinating and 15 were hemolytic. The results suggest that some lectins can serve...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Bhalla V,Gaur V,Bhatia K

    更新日期:1978-01-01 00:00:00

  • The incidence and consequences of cytomegalovirus transmission via blood transfusion to low birth weight, premature infants in north east Scotland.

    abstract::In a 2-year study involving 133 premature low birth weight (less than 1,500 g) infants, the impact of CMV infection via blood transfusion was assessed. 8.4% (7 out of 83) of transfused infants and 10% (7 out of 70) of those exposed to seropositive blood acquired CMV. In those less than 1,250 g the infection rate rose ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Galea G,Urbaniak SJ

    更新日期:1992-01-01 00:00:00

  • Factors related to allergic transfusion reactions and febrile non-haemolytic transfusion reactions in children.

    abstract:BACKGROUND AND OBJECTIVES:Allergic transfusion reactions (ATRs) and febrile non-haemolytic transfusion reactions (FNHTRs) are the two major types of transfusion-related adverse reactions (TRARs). Although prestorage leucocyte reduction and diversion of the first aliquot of blood (LR/D) could reduce FNHTRs and bacterial...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Yanagisawa R,Shimodaira S,Sakashita K,Hidaka Y,Kojima S,Nishijima F,Hidaka E,Shiohara M,Nakamura T

    更新日期:2016-05-01 00:00:00

  • Population study of heterophile antibodies.

    abstract::Sera from 2,829 participants in a population health survey were tested for the presence of a heterophilic antibody, detectable by immunofluorescence. The antibody was found in 9.8% of the sera from women and in 12.4% of the sera from men. The age-specific prevalence of the antibody was relatively constant in women but...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Hawkins BR,Saueracker GC,Dawkins RL,Davey MG,O'Connor KJ

    更新日期:1980-12-01 00:00:00

  • Transmission of hepatitis C virus by anti-HCV-negative blood transfusion. Case report.

    abstract::Acute posttransfusion hepatitis C was reported in a recipient of 3 units of red cells. The recipient became acutely icteric 6 weeks after transfusion, and HCV infection was diagnosed. Stored serum samples of the 3 implicated donations, which were negative with ELISA-2, were retested by PCR and 3rd-generation antibody ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Vrielink H,van der Poel CL,Reesink HW,Zaaijer HL,Lelie PN

    更新日期:1995-01-01 00:00:00

  • Single-dose intravenous iron infusion versus red blood cell transfusion for the treatment of severe postpartum anaemia: a randomized controlled pilot study.

    abstract:BACKGROUND AND OBJECTIVES:There are no randomized trials comparing intravenous iron to RBC transfusion for the treatment of severe postpartum anaemia. The objectives of this study were to evaluate the feasibility of randomizing women with severe postpartum anaemia secondary to postpartum haemorrhage to RBC transfusion ...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Holm C,Thomsen LL,Norgaard A,Langhoff-Roos J

    更新日期:2017-02-01 00:00:00

  • Current status of oxygen carriers ('blood substitutes'): 2006.

    abstract::An alternative to blood transfusion, based on oxygen-carrying solutions, has been sought for over a century. The present 'first-generation' haemoglobin-products were based on observations that crosslinking with, for example, glutaraldehyde, overcame subunit dissociation and renal toxicity. Experience with these soluti...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审


    authors: Winslow RM

    更新日期:2006-08-01 00:00:00

  • Parallel comparison of apheresis-collected platelet concentrates stored in four different additive solutions.

    abstract:BACKGROUND AND OBJECTIVES:Partially replacing plasma with additive solutions in platelet (PLT) concentrates (PCs) may help to reduce transfusion reactions. Constituents of PLT additive solutions (PASs) have been revealed to affect the quality of PCs. Previous studies involved pairwise comparison of identical PLTs with ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Nogawa M,Naito Y,Chatani M,Onodera H,Shiba M,Okazaki H,Matsuzaki K,Satake M,Nakajima K,Tadokoro K

    更新日期:2013-11-01 00:00:00

  • Cold lymphocytotoxins. Chromatographical study.

    abstract::A chromatographical study was made of eight antisera containing either anti-HL-A antibodies, cold lymphocytotoxins, or a mixture of both types of antibodies. The results vary according to the sera obtained. Usually cold lymphocytotoxins are sited in the IgM peak and anti-HL-A antibodies in the IgG peak, but there are ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Mayer S,Hauptmann G,Tongio MM

    更新日期:1976-01-01 00:00:00

  • Segregation of proteins and sodium in human plasma upon freezing.

    abstract::The proteins and sodium in human source blood plasma are segregated and concentrated on freezing, particularly in plasma that is frozen slowly in a large container. The temperature and the concentration gradients at the freezing front induce a convection in the liquid phase and thus play the primary role in the segreg...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Chang CE

    更新日期:1983-01-01 00:00:00

  • Anti-granulocyte antibody screening with extracted granulocyte antigens by a micro-mixed passive hemagglutination method.

    abstract:BACKGROUND AND OBJECTIVES:Serologic tests for granulocyte antibodies, i.e., the granulocyte agglutination test and the granulocyte immunofluorescence test, require panels of typed granulocytes that cannot be preserved for more than a few hours. We have developed a new method in which granulocyte antigens, extracted int...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章


    authors: Araki N,Nose Y,Kohsaki M,Mito H,Ito K

    更新日期:1999-01-01 00:00:00

  • Photoinactivation of Leishmania donovani infantum in red cell suspensions by a flexible thiopyrylium sensitizer.

    abstract:BACKGROUND AND OBJECTIVES:Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania, which are intracellular parasites of monocytes and macrophages. Transmission of the organism has been observed by transfusion of infected blood from asymptomatic donors to immunocompromised recipients, leading to...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Wagner SJ,Skripchenko A,Salata J,Cardo LJ

    更新日期:2006-08-01 00:00:00

  • Blood donations indeterminate in HIV-1 western blot analysed by IgM immunoblot and polymerase chain reaction.

    abstract::The presence of IgM antibodies to human immunodeficiency virus 1 (HIV-1) was investigated in blood donor sera which were indeterminate in anti-HIV-1 IgG Western blot testing. In 7 of 173 instances out of approximately 1,000,000 blood donation sera with an isolated anti-p24 IgG produced an anti-gp41-45 IgM immunoblot r...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Knüver-Hopf J,Heinze H,Lambrecht B,Mohr H,Beyer J,Schmitt H

    更新日期:1993-01-01 00:00:00

  • Direct comparison of three residual risk models for hepatitis B virus window period infections using updated input parameters.

    abstract:BACKGROUND AND OBJECTIVES:Comparison of two models for estimating residual transfusion transmission risk by NAT screened window period (WP) donations in South African repeat donors gave identical results for HIV but not for HBV. In order to understand discrepant HBV modelling outcomes, the values of input parameters in...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审


    authors: Lelie N,Vermeulen M,van Drimmelen H,Coleman C,Bruhn R,Reddy R,Busch M,Kleinman S

    更新日期:2020-04-01 00:00:00

  • Modified formulation of CPDA for storage of whole blood, and of SAGM for storage of red blood cells, to maintain the concentration of 2,3-diphosphoglycerate.

    abstract:BACKGROUND AND OBJECTIVES:A dramatic decrease in the level of 2,3-diphosphoglycerate (2,3-DPG) takes place during the storage of whole blood (WB) in CPDA (citrate-phosphate-dextrose-adenine) and a similar decrease occurs during the storage of red blood cells (RBCs) in SAGM (saline-adenine-glucose-mannitol). The aim of ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Kurup PA,Arun P,Gayathri NS,Dhanya CR,Indu AR

    更新日期:2003-11-01 00:00:00

  • Platelets stored in a new-generation container differences between plasma and platelet additive solution II.

    abstract:BACKGROUND AND OBJECTIVES:In order to preserve platelet concentrates (PCs) with high yields, a new polyolefin platelet storage container (PL 2410, 1.3L, Baxter, La Châtre, France) with increased gas permeability in combination with a larger surface area has been developed. The storage capacity was studied with platelet...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: de Wildt-Eggen J,Schrijver JG,Smid WM,Joie M,Bollinne V,Bins M

    更新日期:1998-01-01 00:00:00

  • Donor follow-up of influenza vaccine-related multiple viral enzyme immunoassay reactivity.

    abstract::False-positive enzyme immunoassay (EIA) tests in blood donors receiving influenza vaccine were first reported in 1991. We conducted follow-up testing for 6 months of those donors with multiply reactive, but unconfirmed EIA (at least 2 positives in anti-HCV-1.0, anti-HIV-1, and anti-HTLV-I assays) with a history of rec...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Arnold NL,Slade BA,Jones MM,Popovsky MA

    更新日期:1994-01-01 00:00:00

  • MN typing discrepancies based on GYPA-B-A hybrid.

    abstract:BACKGROUND AND OBJECTIVES:Gene conversion events between GYPA and GYPB or GYPA and GYPE are facilitated by the close chromosomal proximity and high degree of sequence homology and can lead to the formation of GP hybrid genes. Discrepant results between blood group genotyping and haemagglutination in 22 random blood don...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Polin H,Danzer M,Reiter A,Brisner M,Gaszner W,Weinberger J,Gabriel C

    更新日期:2014-11-01 00:00:00

  • Frozen recovered red cell boosting of female donors for anti-D-production.

    abstract::A selected group of women previously immunized in pregnancy by the Rh(D) antigen were boosted with 0.5 ml of Rh(D)-positive frozen recovered red cells from an accredited donor panel. The response was prompt and sustained and increased the anti-D content by almost 10-fold. In spite of the reduced rate of clinical immun...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Gabra GS,Black M,Mitchell R

    更新日期:1986-01-01 00:00:00

  • T-cell subsets in autologous and allogeneic peripheral blood stem cell concentrates.

    abstract:BACKGROUND AND OBJECTIVES:Regulatory T cells (Tregs) and other T-cell subsets are of importance in the setting of autologous and allogeneic stem cell transplantations. We conducted a study to assess the content of peripheral blood stem cell concentrates and related apheresis parameters in the autologous and allogeneic ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Strobel J,Moellmer I,Zingsem J,Hauck-Dlimi B,Eckstein R,Strasser E

    更新日期:2015-11-01 00:00:00

  • A radial immunodiffusion method for the measurement of rat fibrinogen and fibrin degradation products.

    abstract::The present report describes a technique for the production of monospecific rabbit antiserum to rat fibrinogen and its use in a quantitative radial immunodiffusion assay for measurement of rat fibrinogen and fibrin degradation products. It is a suitable technique for measurement of these parameters in small samples wh...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Kaplan JE,Blumenstock FA,Saba TM

    更新日期:1979-01-01 00:00:00

  • A rapid automated latex screen for tetanus toxoid antibodies.

    abstract::This report describes the sensitisation of latex particles and the use of this reagent on the Autotape system to select blood donations containing greater than or equal to 4 IU/ml of tetanus toxoid antibody. Plasma containing tetanus toxoid antibodies is processed to provide immunoglobulin for passive protection again...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Booth JR,Nuttall PA

    更新日期:1978-01-01 00:00:00

  • Removal of hepatitis B virus infectivity from human gamma-globulin prepared by ion-exchange chromatography.

    abstract::Hepatitis B virus infectivity can be removed from human plasma used to prepare a gamma-globulin product by ion-exchange chromatography with commercially available resins. A pooled human plasma sample free of hepatitis markers was contaminated with 10,000 chimpanzee infectious doses of hepatitis B virus per milliliter ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Zolton RP,Padvelskis JV,Kaplan PM

    更新日期:1985-01-01 00:00:00

  • Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation.

    abstract:BACKGROUND AND OBJECTIVES:Red-blood-cell (RBC) transfusion is associated with lung injury, which is further exacerbated by mechanical ventilation. Manufacturing methods of blood products differ globally and may play a role in the induction of pulmonary cell activation through alteration of the immunomodulatory property...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Wirtz MR,Almizraq RJ,Weber NC,Norris PJ,Pandey S,Spinella PC,Muszynski JA,P Acker J,Juffermans NP

    更新日期:2020-07-01 00:00:00

  • Measuring clinical bleeding using a standardized daily report form and a computer algorithm for adjudication of WHO bleeding grades.

    abstract:INTRODUCTION:Bleeding is increasingly considered an important end point in clinical platelet transfusion studies. Accurate recording and adjudication into well-defined bleeding grades, however, remains a major challenge. METHODS:We developed a computer algorithm for automatic adjudication. The algorithm's results were...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Middelburg RA,Ypma PF,van der Meer PF,van Wordragen-Vlaswinkel RJ,Eissen O,Kerkhoffs JL

    更新日期:2013-08-01 00:00:00

  • Novel system for storage of buffy-coat-derived platelet concentrates in a glucose-based platelet additive solution: parameters and metabolism during storage and comparison to plasma.

    abstract:BACKGROUND:In Europe, buffy-coat processing allows for the use of platelet additive solutions (PAS). These solutions, however, have long been questioned for their lack of glucose, a potentially essential nutrient for platelet storage. Using a novel, practical, two-part system for incorporation of glucose into an additi...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Gyongyossy-Issa MI,Zhang JG,Culibrk B,Hunter F,Levin E,Scammell K,Weiss S,Holmes DL,Holme S

    更新日期:2009-08-01 00:00:00

  • Evaluation of two-step haemoglobin screening with HemoCue for blood donor qualification in mobile collection sites.

    abstract:BACKGROUND AND OBJECTIVES:Inaccuracy of fingerstick haemoglobin compromises donor's health and losses blood donations. We evaluated the benefit of double haemoglobin screening with HemoCue. STUDY DESIGN AND METHODS:Blood donors underwent fingerstick screening by HemoCue and were driven for donation if capillary haemog...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Gómez-Simón A,Plaza EM,Torregrosa JM,Ferrer-Marín F,Sánchez-Guiu I,Vicente V,Lozano ML,Rivera J

    更新日期:2014-11-01 00:00:00

  • Increase in glycocalicin levels in platelet concentrates stored in plasma or synthetic medium for 8 days: comparison with other platelet activation markers.

    abstract:BACKGROUND AND OBJECTIVES:Glycocalicin (GC) is a proteolytic fragment of GpIb and can conveniently be measured in supernatants of platelet concentrates (PCs) by means of a sandwich ELISA. Because of the convenience of the assay and easy sample storage, we tested its suitability as a sensitive platelet activation parame...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Kostelijk EH,Folman CC,Gouwerok CW,Kramer CM,Verhoeven AJ,de Korte D

    更新日期:2000-01-01 00:00:00

  • Purification of human immunoglobulin G: a new approach to plasma fractionation.

    abstract:BACKGROUND AND OBJECTIVES:Currently, plasma fractionation involves multiple processing steps using established methods such as ethanol precipitation and column chromatography. The known limitations associated with conventional purification techniques, combined with strict regulations on safety and high demand for parti...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Li G,Stewart R,Conlan B,Gilbert A,Roeth P,Nair H

    更新日期:2002-11-01 00:00:00

  • Development of white blood cell fragments, during the preparation and storage of platelet concentrates, as measured by using real-time polymerase chain reaction.

    abstract:BACKGROUND AND OBJECTIVES:White blood cell (WBC) fragments may cause human leucocyte antigen (HLA) immunization in recipients. We investigated the occurrence and production of WBC fragments in platelet concentrates (PCs) and plasma units, during storage and filtration, by using real-time polymerase chain reaction (PCR)...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Dijkstra-Tiekstra MJ,van der Schoot CE,Pietersz RN,Huijgens PC,van der Meer PF,Reesink HW

    更新日期:2004-11-01 00:00:00