Prospective study of posttransfusion hepatitis in cardiac surgery patients receiving only blood or also blood products.

Abstract:

:The incidence, etiology and risk factors of posttransfusion (PT) hepatitis were evaluated in a prospective study of 297 consecutive open-heart surgery patients. PT hepatitis occurred in 63 (21.2%) patients with a significantly higher hepatitis attack rate in 51 recipients of commercial clotting factor concentrates (56.8%) compared to 246 recipients of blood units from single volunteer donors (13.8% p less than 0.001). Among the concentrates, Prothrombin-complex showed the highest relative hepatitis risk (24) while in patients receiving only blood, the incidence PT hepatitis was correlated with the blood volume transfused. Of the 63 patients with PT hepatitis, 2 (3%) had hepatitis B, 8 (13%) showed evidence of cytomegalovirus infection and 53 (84%) had non-A, non-B hepatitis. These results show that in Italy, as elsewhere, non-A, non-B PT hepatitis is frequent, particularly when commercial blood products are used.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Tremolada F,Chiappetta F,Noventa F,Valfrè C,Ongaro G,Realdi G

doi

10.1111/j.1423-0410.1983.tb04099.x

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

25-30

issue

1

eissn

0042-9007

issn

1423-0410

journal_volume

44

pub_type

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