Abstract：
BACKGROUND AND OBJECTIVES:One of the challenges surrounding blood component administration is the determination of an appropriate rate of infusion. There are very few evidence-based guidelines available to guide healthcare providers looking for a 'standard' infusion rate for red blood cells (RBCs), plasma or platelets (PLTs). Our objective was to determine the extent to which blood component infusion rates were associated with changes in transfusion recipient vital signs. MATERIALS AND METHODS:We retrospectively examined records of 3496 component infusions (RBCs, n = 2359; PLTs, n = 478; plasma, n = 659) over a 1-year period at a 362-bed multispecialty hospital. The following data were collected for each transfusion: blood product volume and infusion time, recipient pre- and post-transfusion temperature, blood pressure and pulse rate, and hospital ward where transfusion occurred. RESULTS:Plasma (median 10.4 ml/min) was infused faster than PLTs (median 7.2 ml/min, P < 0.0001) or RBCs (median 2.3 ml/min, P < 0.0001). For all blood components, infusion rates varied based on the hospital unit performing the infusion. No association was found between relatively fast RBC, plasma or PLT infusion rates (>20 ml/min) and clinically significant reported changes in vital signs. CONCLUSIONS:There does not appear to be a strong correlation between infusion rate and significant changes in recipient temperature, blood pressure or pulse rate. Based on these data, a reasonable rate for routine transfusion is 2-3 ml/min for RBCs and 7-10 ml/min for plasma and PLTs. Faster infusion rates (>20 ml/min) likely can be applied with close patient monitoring if there is a more urgent need for transfusion.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Gehrie EA,Hendrickson JE,Tormey CAdoi
10.1111/vox.12310subject
Has Abstractpub_date
2015-11-01 00:00:00pages
353-8issue
4eissn
0042-9007issn
1423-0410journal_volume
109pub_type
杂志文章相关文献
VOX SANGUINIS文献大全abstract：BACKGROUND AND OBJECTIVES:The last two decades have seen major developments in genotyping assays to facilitate the procurement of red blood cell units to alloimmunized patients. To make genotyping faster, simpler and less costly, a nanotechnology approach based on metal/silica fluorescent nanoparticles and a polymer-ba...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/vox.12207
更新日期：2015-02-01 00:00:00
abstract：:The results of the serological typing and the patterns of restriction fragment length polymorphisms for the detection of HLA-DR gene products are compared. The data shown demonstrate that the use of DNA typing gives a clearer definition of the HLA-DR antigens and that the HLA-DR polymorphism is greater than detected b...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.1991.tb00928.x
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:In order to describe the progression of HIV disease in a cohort of Dutch HIV-1-infected patients with haemophilia and to study the influence of clinical and clotting factors, we performed a 15-year longitudinal clinical and laboratory study. METHODS:The progression to AIDS in relation to type of haemophilia,...
journal_title：Vox sanguinis
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The supply of phenotyped red blood cells (RBC) for patients with several RBC antibodies presents a difficult task to hospital blood banks and regional blood centers. The aim of this study was to establish a low-cost typing system to allow extensive phenotyping of regular blood donors for clini...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1159/000031093
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Autoantibodies to CD36, a platelet glycoprotein, have been found in patients with thrombotic thrombocytopenic purpura, and in those with lupus-like anticoagulant with thrombotic complications. MATERIALS AND METHODS:Conventional hematologic and laboratory methods were used. The patient was a p...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1046/j.1423-0410.1997.7310046.x
更新日期：1997-01-01 00:00:00
abstract：:A Bombay, Le(a-b-) saliva was shown to lack Pneumococcus type XIV activity, an unusual situation, since this sample should be rich in this precursor to the ABO blood group substances. However, the sample was found to contain a new serological specificity, Le-c. It is argued that simple Mendelian inheritance does not o...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.1975.tb00508.x
更新日期：1975-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Pr1,2,3, PrM, Sa and Sia-l1, -b1, -lb1 are sialic acid (NeuNAc)-dependent antigens recognized by human cold agglutinins. Pr and Sa antigens are the O-glycans of glycophorins containing alpha 2,3NeuNAc (to galactose) and/or alpha 2,6NeuNAc (to galactosamine). The antigens of the Sia-l1, -b1, -l...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The International Haemovigilance Network collects aggregate data on complications of blood donation from member haemovigilance systems (HVS). We analysed the data collected in 2006-2016 in order to learn from it and consider future improvements. MATERIALS AND METHODS:National HVS entered annu...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/vox.13048
更新日期：2020-12-05 00:00:00
abstract：:A number of parasitic diseases are known, or suspected to be transmitted by blood transfusion. Of greatest concern are malaria and Chagas' disease, but babesia, leishmania and toxoplasmosis also offer risk in particular locations or circumstances. Some of these parasites may be imported into non-endemic areas as a res...
journal_title：Vox sanguinis
pub_type： 杂志文章,评审
doi：10.1111/j.1423-0410.1998.tb05415.x
更新日期：1998-01-01 00:00:00
abstract：:We developed a photodynamic method to inactivate viruses in human fresh plasma. Single plasma bags were illuminated with visible light in the presence of low doses of phenothiazine dyes like methylene blue or toluidine blue. By this treatment the infectivity of different enveloped viruses including the causative agent...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.1991.tb00907.x
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:White blood cell (WBC) fragments in platelet concentrates (PCs) may induce allo-immunization in the recipient. MATERIALS AND METHODS:As the level of WBC fragments can differ between PCs produced using different methods, we compared PCs prepared by using the buffy-coat method (BC-PCs) in plasm...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.2005.00634.x
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Despite long being a mainstay in describing platelet activation via degranulation, interlaboratory variation remains an issue in measurement of membrane CD62P by flow cytometry. Our objective was to identify actions that may minimize this variation. MATERIALS AND METHODS:Sixteen laboratories ...
journal_title：Vox sanguinis
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1111/vox.12023
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The ABO blood group system is the most important blood group system in transfusion medicine. In addition to the major A, B and O alleles, many rare alleles have been defined. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and analysis by PCR sequence specific pri...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.2005.00729.x
更新日期：2006-02-01 00:00:00
abstract：:Changes in metabolic and functional activity of platelets stored as platelet concentrates in plastic bags highly permeable to gases were investigated. The following parameters were measured daily: pH, pO2, pCO2, HCO3, glucose, lactic acid, lactic dehydrogenase, cellular ATP and platelet aggregation induced by differen...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.1989.tb03043.x
更新日期：1989-01-01 00:00:00
abstract：:Blood group B-gene-specified alpha-galactosyltransferase was determined in serums and erythrocyte membranes of several related persons with Bm phenotypes. The level of this enzyme in serums was similar to, but in erythrocyte membranes much lower than that found in normal B and AB persons. ...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.1976.tb04834.x
更新日期：1976-01-01 00:00:00
abstract：:Spectrophotometric and gas-liquid chromatographic analyses on the carbohydrate moiety of tryptic erythrocyte glycopeptides from persons with Tn-syndrome reveal a selective lowering of the galactose and sialic acid content, the degree being dependent on the percentage of polyagglutinable cells. Alkaline borohydride spe...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.1975.tb00475.x
更新日期：1975-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The membrane transporter ABCB6 has recently been shown to carry the high-frequency red-blood-cell (RBC) antigen Lan. All the Lan- individuals genotyped so far have inherited two recessive null mutations in ABCB6. The finding of a family with the Lan- blood type occurring in two successive gener...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.2012.01650.x
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:There are conflicting data regarding the therapeutic efficacy of platelets inactivated using amotosalen and ultraviolet A light. We have performed a meta-analysis to summarize the results of different randomized controlled trials (RCT). MATERIALS AND METHODS:Five RCTs reported through March 2...
journal_title：Vox sanguinis
pub_type： 杂志文章,meta分析
doi：10.1111/j.1423-0410.2012.01614.x
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The clinical significance of immune thrombocytopenia (ITP) is mainly reflected by bleeding and/or bleeding risks, which, in some cases, cannot be adequately controlled by standard therapy. Tranexamic acid (TA) is increasingly used in preventing and reducing bleeding in several medical settings...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/vox.12549
更新日期：2017-11-01 00:00:00
abstract：:Two preparations of fresh frozen plasma were studied. The plasma from CPDA-1 whole blood units was either frozen within 6 h (FFP-I) or 18-20 h (FFP-II) of phlebotomy. Average activity for factor VIII for FFP-I (n = 6) and FFP-II (n = 19) was 102% and 55%, respectively (p less than 0.01). Average activity for factor V ...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.1984.tb00046.x
更新日期：1984-01-01 00:00:00
abstract：:The authors have studied the incidence of hepatitis associated antigen (HAA) and the homologous antibody in sera of patients with rheumatoid arthritis on the basis of (1) arthritis sometimes associated with viral hepatitis, (2) the possible infectious etiology of rheumatoid arthritis, and (3) observation on the possib...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.1975.tb02735.x
更新日期：1975-01-01 00:00:00
abstract：PURPOSE:To determine the frequency of maternal-fetal hemorrhage at or above 1 microliter of maternal whole blood. METHODS:Seventy-three mothers whose red blood cells bore an Rh antigen (Rh D, Rh c, Rh E) that was absent on red blood cells of their newborns were identified and a new cytological method, the Kleihauerimm...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1046/j.1423-0410.1996.7120103.x
更新日期：1996-01-01 00:00:00
abstract：:A population of human erythrocytes (free A3 cells) which was entirely unagglutinable with anti-A hemagglutinins was successfully separated from human blood group A3 erythrocytes by affinity chromatography on a column of lima bean anti-A hemagglutinin (LBH)-Sepharose. The hemagglutinating and the binding properties of ...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.1978.tb02877.x
更新日期：1978-01-01 00:00:00
abstract：:Paraformaldehyde-fixed platelets from normal donors were used for detection of antibody to platelet by in vitro sensitization (indirect method) utilizing rabbit anti-human IgG heavy chain specific antibody-coated polyacrylamide gels (Immunobeads). The sensitized platelets formed rosettes with Immunobeads and the posit...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.1980.tb01869.x
更新日期：1980-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The A2 is a very rare phenotype in the ABO blood group system in the Oriental population. It corresponds to a special ABO allele encoding a glycosyltransferase that is capable of synthesizing A2 antigens, which is weaker than the typical A antigen. In this study, we report a novel A2 allele in...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.2005.00608.x
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Transfusion of fresh-frozen plasma is still a pillar in emergency medicine for using to prevent dilutional coagulopathy or disseminated intravascular coagulation after severe blood loss, but thawing procedures can delay its availability. On the other hand, the wastage of plasma, once thawed an...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.2004.00552.x
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:A major requirement of a hepatitis C virus (HCV) RNA nucleic acid amplification technology (NAT) assay validation is the ability of the assay to detect the six major genotypes of HCV with equivalent sensitivities. The aim of this study was to characterize and calibrate an HCV genotype panel fo...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1046/j.1423-0410.2003.00260.x
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania, which are intracellular parasites of monocytes and macrophages. Transmission of the organism has been observed by transfusion of infected blood from asymptomatic donors to immunocompromised recipients, leading to...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/j.1423-0410.2006.00810.x
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Practices in end-of-life platelet transfusions in haematologic malignancies are variable. Our aim was to describe the platelet transfusion burden and parameters linked to this indication in such a setting and thereby contribute to defining optimal practices. MATERIALS AND METHODS:From July 20...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1111/vox.12986
更新日期：2020-08-13 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The para-Bombay phenotype (also known as H-deficient secretor) is characterized by a lack of ABH antigens on red cells, but ABH substances are found in saliva. Molecular genetic analysis was performed for five Chinese individuals serologically typed as para-Bombay. MATERIALS AND METHODS:ABO g...
journal_title：Vox sanguinis
pub_type： 杂志文章
doi：10.1046/j.1423-0410.2002.00184.x
更新日期：2002-10-01 00:00:00
