Abstract:
:Spectrophotometric and gas-liquid chromatographic analyses on the carbohydrate moiety of tryptic erythrocyte glycopeptides from persons with Tn-syndrome reveal a selective lowering of the galactose and sialic acid content, the degree being dependent on the percentage of polyagglutinable cells. Alkaline borohydride specifically releases N-acetylgalactosaminitol, and the amount is correlated to the percentage of pathological acetylgalactosaminitol, and the amount is correlated to the percentage of pathological erythrocytes. It is concluded that the alkali-labile carbohydrate chains of Tn-polyagglutinable red cells solely consist of N-acetylgalactosamine linked to serine or threonine. Experiments with heterophile agglutinins whose specificity is known are in line with the above-mentioned results. As judged from SDS-polyacrylamide gel electrophoresis the three major membrane glycoproteins are affected to a different extent by the defect.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Dahr W,Uhlenbruck G,Gunson HH,Van Der Hart Mdoi
10.1111/j.1423-0410.1975.tb00475.xsubject
Has Abstractpub_date
1975-01-01 00:00:00pages
36-50issue
1eissn
0042-9007issn
1423-0410journal_volume
29pub_type
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