Abstract:
BACKGROUND AND OBJECTIVES:B subgroups are rare and the genetic analysis reported to date has been limited. MATERIALS AND METHODS:Serological and molecular investigations were performed in blood from a B-subgroup donor. RESULTS:Red cells did not react with anti-B and anti-AB reagents. However, cells absorbed anti-B. Red cells presented positive reactions with anti-H, and saliva secreted H substance. The molecular study demonstrated a B allele with the substitutions 467C>T, 646T>A, 681G>A, 771C>T, 796C>A, 803G>C, 829G>A and an O allele with the sequence of O02. CONCLUSIONS:It is probable that the presence in exon 7 of some of the O02 substitutions could have weakened the enzymatic activity of the encoded B transferase.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Sousa N,Anicchino-Bizzacchi JM,Leite EM,Locatelli MF,Albuquerque D,Costa FF,Barjas-Castro MLdoi
10.1111/j.1423-0410.2005.00583.xsubject
Has Abstractpub_date
2005-01-01 00:00:00pages
31-4issue
1eissn
0042-9007issn
1423-0410pii
VOX583journal_volume
88pub_type
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