Abstract:
:The pretreatment of LEW (RT-1l) rat recipients with antibody-coated BN (RT-1n) blood cells resulted in the suppression of the LEW antibody response against subsequent BN platelet and leukocyte transfusions. Both coating with homologous LEW-anti-BN serum or heterologous rabbit-anti-rat lymphocyte serum was effective. Repeated boosting with uncoated platelets or leukocytes did not abrogate the suppression. The degree of suppression was dependent on the amount of antibody used for cell coating. The induced suppression was also extended to uncoated antigens and unrelated third-party cells. The serum-IgG fraction of pretreated rats was strongly immunosuppressive, suggesting that the mechanism of suppression was related to the induction of a broadly reactive regulatory IgG.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Süsal C,Terness P,Opelz Gdoi
10.1111/j.1423-0410.1990.tb00238.xsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
209-15issue
4eissn
0042-9007issn
1423-0410journal_volume
59pub_type
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