Cytokine profile of autologous platelet-derived eye drops in patients with ocular chronic graft-versus-host disease.

Abstract:

:Ocular chronic GVHD is efficaciously treated with autologous platelet-derived eye drops. We investigated the cytokine content of eye drops produced using a non-gelified lysate obtained from autologous platelet-rich plasma in six patients with ocular GVHD. In both the responding (n = 4) and the resistant (n = 2) patients, the eye drops were significantly enriched with various growth factors, in amounts proportional with the platelet counts. In contrast, chemokine ligand and interleukin levels were similar to those of plasma. The non-responding patients showed the highest levels of chemokine (C-X-C motif) ligand (CXCL)10. These findings provide possible explanations for beneficial or detrimental effects of eye drops.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Valentini CG,Nuzzolo ER,Orlando N,Metafuni E,Bianchi M,Chiusolo P,Zini G,Teofili L

doi

10.1111/vox.12325

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

189-92

issue

2

eissn

0042-9007

issn

1423-0410

journal_volume

110

pub_type

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