Abstract:
:Acute posttransfusion hepatitis C was reported in a recipient of 3 units of red cells. The recipient became acutely icteric 6 weeks after transfusion, and HCV infection was diagnosed. Stored serum samples of the 3 implicated donations, which were negative with ELISA-2, were retested by PCR and 3rd-generation antibody tests. One implicated donation was PCR positive, but anti-HCV negative. Both other donations were negative in all tests. The donor was recalled to the Blood Bank 13 weeks after the implicated donation and was found to be ELISA-3 plus RIBA-3 positive. Eight months after the implicated donation, the donor is still PCR and RIBA-3 positive, whereas the recipient became PCR negative but remained anti-HCV RIBA-3 positive. The case shows that blood products from donors collected during the open window period of an HCV infection can transmit HCV to recipients.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Vrielink H,van der Poel CL,Reesink HW,Zaaijer HL,Lelie PNdoi
10.1111/j.1423-0410.1995.tb02546.xsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
55-6issue
1eissn
0042-9007issn
1423-0410journal_volume
68pub_type
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