Genetic control of immune responsiveness in man.

Abstract:

:Interest in immunogenetics originated from two streams: (a) histocompatibility in mouse and man, and (b) inheritance of specific immune responses in the guinea pig and mouse. In the mouse, there are genes associated with the major histocompatibility complex (MHC) which (i) code for antigens determining allograft responses and mixed lymphocyte reactions, (ii) control responses to certain antigens (Ir genes), and (iii) code for cell-surface antigens which elicit specific antisera (anti-Ia). In man, there is genetic control, in part X-linked, over levels of immunoglobulins and immunoglobulin classes. Evidence for MHC-linked genetic control is derived from immune responses to (i) micro-organisms, (ii) pollen antigens, (iii) food antigens, (iv) vaccines, (v) inocuous test antigens, and (vi) autoantigens. Some evidence exists for allotype-linked genetic control. Practical aspects concern influences of the MHC on susceptibility to disease, within individuals and populations.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Mackay IR,Wittingham S,Tait B

doi

10.1111/j.1423-0410.1977.tb00598.x

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

10-9

issue

1

eissn

0042-9007

issn

1423-0410

journal_volume

32

pub_type

历史文章,杂志文章
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