Recombinant activated factor VII (NovoSeven): addition to replacement therapy in acute, uncontrolled and life-threatening bleeding.


BACKGROUND AND OBJECTIVES:Recombinant activated factor VII (rFVIIa, NovoSeven) has been used off-label for various conditions. A protocol for its use in acute, uncontrolled life-threatening bleeding, was devised and employed. A haematologist/transfusion specialist was assigned as a member of the team. MATERIALS AND METHODS:The clinical data were reviewed and summarized. A scoring system for the assessment and monitoring of coagulopathy was employed. Each parameter of prothrombin time (PT), activated partial thromboplastin time (aPTT), platelet number and fibrinogen level was allocated points according to the degree of abnormality. Three scoring levels emerged. RESULTS:Between April 2001 and April 2003, 13 patients received rFVIIa for acute, uncontrolled life-threatening bleeding. Nine of 13 patients remained alive for 15 days or longer after rFVIIa infusion. All patients who experienced a reduction or cessation of bleeding after rFVIIa infusion, also had a lower coagulopathy score after replacement therapy, prior to rFVIIa infusion, compared with their score at rFVIIa request. There was a reduction in the average use of blood products after rFVIIa infusion. The coagulopathy score was statistically predictive of response to rFVIIa and survival. CONCLUSIONS:In an area where very little data exists, we report the usefulness of rFVIIa. We propose that transfusion replacement should aim to correct coagulopathy before infusion of rFVIIa and that a haematologist/transfusion specialist should be involved in the management of these patients. A prognostically significant coagulopathy scoring system is offered.


Vox Sang


Vox sanguinis


Mayo A,Misgav M,Kluger Y,Geenberg R,Pauzner D,Klausner J,Ben-Tal O




Has Abstract


2004-07-01 00:00:00














  • The D antigen characteristic of RoHar is a partial D antigen.

    abstract::The results of testing RoHarr cells with panels of monoclonal anti-D suggest that the D antigen (referred to as DHar) encoded by the haplotype (D)c(e) Rh33 is a partial D antigen. IgM monoclonal anti-D are more efficient than IgG monoclonal anti-D in detecting DHar.DHar expresses some but not all of both epD5 and epD6...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Wallace M,Lomas-Francis C,Tippett P

    更新日期:1996-01-01 00:00:00

  • Complications of blood donation reported to haemovigilance systems: analysis of eleven years of international surveillance.

    abstract:BACKGROUND AND OBJECTIVES:The International Haemovigilance Network collects aggregate data on complications of blood donation from member haemovigilance systems (HVS). We analysed the data collected in 2006-2016 in order to learn from it and consider future improvements. MATERIALS AND METHODS:National HVS entered annu...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Wiersum-Osselton JC,Politis C,Richardson C,Goto N,Grouzi E,Marano G,Land KJ

    更新日期:2020-12-05 00:00:00

  • Intraoperative autologous blood recovery in prostate cancer surgery: in vivo validation using a tumour marker.

    abstract:BACKGROUND AND OBJECTIVE:Intraoperative autologous blood recovery during radical retro pubic prostatectomy has the potential of contamination with tumour cells. Its safety is proved by similar survival rates between allogeneic and autologous transfusion to oncology patients without standardization. Silencing of the gen...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Poli M,Camargo A,Villa L,Moura R,Colella R,Deheinzelin D

    更新日期:2008-11-01 00:00:00

  • Molecular bases of the ABO blood groups of Indians from the Brazilian Amazon region.

    abstract::Phenotype studies of ABO blood groups in most Amerindian populations revealed the exclusive presence of group O. Since group O is the result of the absence of glycosyltransferase activity, its molecular bases may be heterogeneous. We carried out ABO blood group genotyping by analysis of DNA of 30 Indians from 2 Amazon...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Franco RF,Simões BP,Guerreiro JF,Santos SE,Zago MA

    更新日期:1994-01-01 00:00:00

  • The non-Mendelian inheritance of Lewis-c blood group substance, as demonstrated in the case of a Bombay, Le(a-b-c-) saliva.

    abstract::A Bombay, Le(a-b-) saliva was shown to lack Pneumococcus type XIV activity, an unusual situation, since this sample should be rich in this precursor to the ABO blood group substances. However, the sample was found to contain a new serological specificity, Le-c. It is argued that simple Mendelian inheritance does not o...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Savvas RS

    更新日期:1975-01-01 00:00:00

  • Accumulation of soluble inflammatory mediators between blood donation and pre-storage leucocyte depletion.

    abstract:BACKGROUND AND OBJECTIVES:Leucocyte-derived cytokines accumulate in stored whole blood. Pre-storage leucocyte depletion has reduced cytokine levels and, consequently, febrile non-haemolytic transfusion reactions. As leucocyte filtration and component separation can be performed until 24 h after donation, we hypothesize...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Chudziak D,Sireis W,Pfeiffer HU,Henschler R,Seifried E,Bönig H

    更新日期:2009-02-01 00:00:00

  • Collaborative study to calibrate hepatitis C virus genotypes 2-6 against the HCV International Standard, 96/790 (genotype 1).

    abstract:BACKGROUND AND OBJECTIVES:A major requirement of a hepatitis C virus (HCV) RNA nucleic acid amplification technology (NAT) assay validation is the ability of the assay to detect the six major genotypes of HCV with equivalent sensitivities. The aim of this study was to characterize and calibrate an HCV genotype panel fo...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Saldanha J,Heath A,Collaborative Study Group.

    更新日期:2003-01-01 00:00:00

  • 'One step closer': Acceptability of a programme of plasma donation for fractionation from men who have sex with men.

    abstract:BACKGROUND AND OBJECTIVES:In Canada, Héma-Québec is considering the possibility of allowing men who have sex with men (MSM) to donate plasma for fractionation combined with a mandatory quarantine period. This study aims to assess the acceptability and operational feasibility of the programme in the targeted population....

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Caruso J,Germain M,Godin G,Myhal G,Pronovost F,Morin M,Otis J

    更新日期:2019-10-01 00:00:00

  • Correlation of in vitro platelet quality measurements with in vivo platelet viability in human subjects.

    abstract:BACKGROUND AND OBJECTIVES:Changes in in vitro platelet quality parameters during platelet storage are associated with a decrease of in vivo platelet viability after platelet transfusion. Many attempts have been made to identify the most predictable in vitro parameters for in vivo performance. We used a riboflavin-based...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Goodrich RP,Li J,Pieters H,Crookes R,Roodt J,Heyns Adu P

    更新日期:2006-05-01 00:00:00

  • Blood donors infected with the hepatitis B virus but persistently lacking antibodies to the hepatitis B core antigen.

    abstract:BACKGROUND AND OBJECTIVES:Antibodies to the core of hepatitis B virus (anti-HBc) are considered to be the best serologically reliable markers of hepatitis B virus (HBV) infection. Through a national epidemiological survey, two young and first-time blood donors, originating from HBV-endemic areas, were identified as HBV...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Laperche S,Guitton C,Smilovici W,Courouce AM

    更新日期:2001-02-01 00:00:00

  • A new method to collect granulocytes using a low dose of hydroxyethyl starch.

    abstract::A new granulocyte collection method employing discontinuous flow centrifugation and low donor dose of hydroxyethyl starch (HES) is presented. Following the procedure, the increase in serum polysaccharide concentration was 100 mg/dl, about 20% of that seen after standard discontinuous flow leukapheresis. The average ef...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Szymanski IO

    更新日期:1983-01-01 00:00:00

  • Transfusion transmitted hepatitis C and non-A, non-B, non-C.

    abstract::The decline in the incidence of TAH from 1985-1990 was considerable and based on a variety of interventions that led to increasingly intensive scrutiny of potential donors. The decline in incidence observed since 1990, and particularly since 1992, has been truly extraordinary and based principally on the introduction ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审


    authors: Alter HJ

    更新日期:1994-01-01 00:00:00

  • Monitoring bacterial contamination of blood components in Germany: effect of contamination reduction measures.

    abstract:BACKGROUND AND OBJECTIVES:National guidelines for monitoring bacterial contamination of blood components were introduced in Germany in 1997. Between 1998 and 2002, numerous measures were implemented to prevent bacterial contamination. This study investigates their impact on contamination rates. MATERIALS AND METHODS:C...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Walther-Wenke G,Wirsing von König CH,Däubener W,Heiden M,Hoch J,Hornei B,Volkers P,Working Party on Bacteria Safety in Transfusion Medicine, Advisory Board of the German Ministry of Health, Berlin.

    更新日期:2011-05-01 00:00:00

  • A1 weak B phenotypes found in two generations of a Romanian family: A1Bx versus cis AB complex.

    abstract::Three 'A1 weak B' blood groups found in two generations of a Romanian family were studied with quantitative and thermodynamic assays in order to determine if they derive from 'A1Bx' or from 'cis AB' genotypes, what cannot be achieved by the genetics. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Lopez M,Danielescu M,Liberge G,Salmon C

    更新日期:1975-01-01 00:00:00

  • Feasibility of reducing the maximum shelf life of red blood cells stored in additive solution: a dynamic simulation study involving a large regional blood system.

    abstract:BACKGROUND AND OBJECTIVE:Recent studies suggest that transfusion of old red blood cell (RBC)s, mainly those close to the 42-day maximum shelf life (MSL), is associated with increased morbi-mortality. Although there is no formal proof supporting a causal relationship, the precautionary principle asks for corrective inte...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Grasas A,Pereira A,Bosch MA,Ortiz P,Puig L

    更新日期:2015-04-01 00:00:00

  • Performance evaluation study of ID RHD XT, a new genotyping assay for the detection of high-prevalence RhD negative and weak D types.

    abstract:BACKGROUND AND OBJECTIVES:Routine serologic D typing does not distinguish between weak D subtypes and partial D phenotypes. The goal of this study was to validate the performance of the ID RHD XT genotyping assay. MATERIAL AND METHODS:Previously serotyped samples for D antigen (n = 1000; 16% weak D serotyped donors) w...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Molano A,Apraiz I,España P,Azkarate M,Vesga MÁ,Rubia M,Piedrabuena M,Puente F,Veldhuisen B,van der Schoot E,Tejedor D,López M

    更新日期:2018-10-01 00:00:00

  • Rh haplotypes that make e but not hrB usually make VS.

    abstract:BACKGROUND AND OBJECTIVES:The Rh phenotypes hrB- and VS+ are both rare in Whites but more common in Blacks. The high-incidence antigen hrB is present on most red cells that are e+. The presence of VS on red cells is associated with an aberrant expression of e, often called eS. MATERIALS AND METHODS:Using conventional ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Reid ME,Storry JR,Issitt PD,Combs MR,Beal CL,Mallory DA,Blancher A

    更新日期:1997-01-01 00:00:00

  • Removal of hepatitis B virus infectivity from human gamma-globulin prepared by ion-exchange chromatography.

    abstract::Hepatitis B virus infectivity can be removed from human plasma used to prepare a gamma-globulin product by ion-exchange chromatography with commercially available resins. A pooled human plasma sample free of hepatitis markers was contaminated with 10,000 chimpanzee infectious doses of hepatitis B virus per milliliter ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Zolton RP,Padvelskis JV,Kaplan PM

    更新日期:1985-01-01 00:00:00

  • Anticore antibody screening of transfused blood.

    abstract::Aliquots of 130 HB8Ag negative units of blood which were administered to 26 recipients were tested under code for anti-HBc by a solid phase radioimmunoassay technqiue. 14 of the 26 recipients developed posttransfusion hepatitis (PTH), including 6 cases of hepatitis B. Anti-HBc was detected in 7 or 5.3% of 130 donor un...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Lander JJ,Gitnick GL,Gelb LH,Aach RD

    更新日期:1978-01-01 00:00:00

  • Effect of heat on stored red cells during non-flow conditions in a blood-warming device.

    abstract:BACKGROUND AND OBJECTIVES:While blood is flowing within a transfusion-warming device, the blood temperature is usually less than that applied externally. If the flow is temporarily stopped, the temperature can rise above 37 degrees C in some warming devices. We sought to determine whether temperatures near 45 degrees C...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Eastlund T,Van Duren A,Clay ME

    更新日期:1999-01-01 00:00:00

  • Investigation of the thrombin-generating capacity, evaluated by thrombogram, and clot formation evaluated by thrombelastography of platelets stored in the blood bank for up to 7 days.

    abstract:BACKGROUND AND OBJECTIVES:Transfusion based on the Thrombelastograph (TEG) results reduces transfusion requirements in cardiac surgery and in liver transplantation. Taking the pivotal role of thrombin generation in the coagulation process into consideration, the clinical utility of the TEG may, in part, depend on its r...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Johansson PI,Svendsen MS,Salado J,Bochsen L,Kristensen AT

    更新日期:2008-02-01 00:00:00

  • Monocyte-erythrocyte interaction in autoimmune haemolytic anaemia in relation to the number of erythrocyte-bound IgG molecules and subclass specificity of autoantibodies.

    abstract::Monocyte-erythrocyte interaction in patients with autoimmune haemolytic anaemia (AIHA) was assessed by phagocytosis and rosette assays. In most patients, a relationship was observed between haemolysis and the phagocytosis of their own erythrocytes by allogenic peripheral monocytes. An evaluation of the number of immun...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Zupańska B,Brojer E,Thomson EE,Merry AH,Seyfried H

    更新日期:1987-01-01 00:00:00

  • Storage of platelets in additive solutions: a multicentre study of the in vitro effects of potassium and magnesium.

    abstract:BACKGROUND AND OBJECTIVES:In a preliminary study, the presence of potassium and magnesium in a modified synthetic medium (PAS-III) was found to have a significant influence on platelet metabolism (using apheresis-derived, as well as buffy-coat-derived platelets) when compared with standard PAS-III. The differences incl...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,多中心研究


    authors: Gulliksson H,AuBuchon JP,Cardigan R,van der Meer PF,Murphy S,Prowse C,Richter E,Ringwald J,Smacchia C,Slichter S,de Wildt-Eggen J

    更新日期:2003-10-01 00:00:00

  • Reduced risk of transfusion-transmitted HIV in Kenya through centrally co-ordinated blood centres, stringent donor selection and effective p24 antigen-HIV antibody screening.

    abstract:BACKGROUND:Following a 1994 study showing a high rate of transfusion-associated HIV, Kenya implemented WHO blood safety recommendations including: organizing the Kenya National Blood Transfusion Service (NBTS), stringent blood donor selection, and universal screening with fourth-generation p24 antigen and HIV antibody ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Basavaraju SV,Mwangi J,Nyamongo J,Zeh C,Kimani D,Shiraishi RW,Madoda R,Okonji JA,Sugut W,Ongwae S,Pitman JP,Marum LH

    更新日期:2010-10-01 00:00:00

  • Isoagglutinins following ABO-incompatible bone marrow transplantation.

    abstract::Isoagglutinins were investigated following ABO-incompatible bone marrow transplantation. In major incompatibility anti-A tends to require more time to disappear than anti-B. Correspondingly, A erythrocytes require more time to become demonstrable. There is no such difference in major plus minor incompatibility. In min...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Wernet D,Mayer G

    更新日期:1992-01-01 00:00:00

  • Platelet concentrates. Influence of different preparative protocols on the in vitro release reaction.

    abstract::To determine what effect different preparative protocols and different platelet storage bags have on in vitro release, platelet concentrates were prepared according to two different protocols (group I: 2,200 g for 3.5 min followed by 4,900 g for 5 min; group II: 1,000 g for 9 min and 3,000 g for 20 min). The storage b...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Snyder EL,Koerner TA Jr,Hezzey A

    更新日期:1982-01-01 00:00:00

  • Group O RBCs: where is universal donor blood being used.

    abstract:BACKGROUND:There have been recurrent shortages of group O blood due to insufficient inventory and use of group O blood in ABO non-identical recipients. We performed a 12-year retrospective study to determine utilization of group O Rh-positive and Rh-negative red blood cells (RBCs) by recipient ABO group. Reasons for tr...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Barty RL,Pai M,Liu Y,Arnold DM,Cook RJ,Zeller MP,Heddle NM

    更新日期:2017-05-01 00:00:00

  • Single-dose intravenous iron infusion versus red blood cell transfusion for the treatment of severe postpartum anaemia: a randomized controlled pilot study.

    abstract:BACKGROUND AND OBJECTIVES:There are no randomized trials comparing intravenous iron to RBC transfusion for the treatment of severe postpartum anaemia. The objectives of this study were to evaluate the feasibility of randomizing women with severe postpartum anaemia secondary to postpartum haemorrhage to RBC transfusion ...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Holm C,Thomsen LL,Norgaard A,Langhoff-Roos J

    更新日期:2017-02-01 00:00:00

  • Plasma temperature during methylene blue/light treatment influences virus inactivation capacity and product quality.

    abstract:BACKGROUND:Photodynamic treatment using methylene blue (MB) and visible light is in routine use for pathogen inactivation of human plasma in different countries. Ambient and product temperature conditions for human plasma during production may vary between production sites. The influence of different temperature condit...

    journal_title:Vox sanguinis

    pub_type: 杂志文章


    authors: Gravemann U,Handke W,Sumian C,Alvarez I,Reichenberg S,Müller TH,Seltsam A

    更新日期:2018-05-01 00:00:00

  • Antibodies to factor VIII in hemophilia A patients.

    abstract::Inhibitor development represents the main complication in the treatment of haemophilia A. The risk of inhibitor formation is in part genetically determined by the type of the underlying factor VIII gene lesion but environmental factors may also play an important role. Due to the lack of efficiency of factor VIII in th...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审


    authors: Brackmann HH,Schwaab R,Effenberger W,Hess L,Hanfland P,Oldenburg J

    更新日期:2000-01-01 00:00:00