Solvent/detergent treatment of human plasma--a very robust method for virus inactivation. Validated virus safety of OCTAPLAS.

abstract：:The number of cord blood transplants has been increasing very quickly with more than 250 cases reported to Eurocord Registry and more than 500 patients transplanted via the New York Cord Blood Bank. Cord blood transplants have been performed either with related or unrelated cord blood. Several cord blood banks establi...

journal_title：Vox sanguinis

authors： Gluckman E,Rocha V,Chastang C

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Continuous-flow and intermittent-flow blood cell separators (CFCS and IFCS) are both used to collect stem cells from the blood to rescue patients undergoing myeloablative treatment for cancer. MATERIALS AND METHODS:We designed a study to compare the collection efficiency of the two systems. T...

journal_title：Vox sanguinis

authors： Beretta F,van den Bosch S,Castelli D,Cavalli F,Ghielmini M

更新日期：1998-01-01 00:00:00

abstract：:Early and regular blood transfusion therapy in patients with homozygous beta-thalassaemia decreases the complications of severe anaemia and prolongs survival. In the long term, however, the beneficial effects of transfusions are limited by the organ damage resulting from iron overload, a consequence of the body's limi...

journal_title：Vox sanguinis

authors： Prati D

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:During the past 10 years several DNA-typing methods have been developed to complement routine serological typing for determination of polymorphisms in the ABO, RH, KEL, JK and FY blood group genes. However, the molecular basis of blood groups can differ widely between ethnic groups. The purpos...

journal_title：Vox sanguinis

authors： Irshaid NM,Ramadan S,Wester ES,Olausson P,Hellberg A,Merza JY,Olsson ML

更新日期：2002-07-01 00:00:00

abstract：:A retrospective analysis was conducted on 20 D(-) liver transplant (LT) recipients transfused with D(+) RBCs perioperatively and screened for RBC antibodies between 2 and 6 months later. None developed anti-D detectable by the indirect antiglobulin test. Two patients produced weak anti-D that reacted only with papain-...

journal_title：Vox sanguinis

authors： Burin des Roziers N,Ibanez C,Samuel D,Francoz C,Idri S,François A,Mortelecque R,Bierling P,Pirenne F

更新日期：2016-07-01 00:00:00

abstract：:BOW is a 'new' low-frequency red-cell antigen, detected in 2 unrelated English blood donors, that is sensitive to alpha-chymotrypsin and pronase. Anti-BOW is present in many polyspecific reagents used to define low-frequency antigens. Red-cell groups of the proposita, R.B., and her family show that the BOW blood group...

journal_title：Vox sanguinis

authors： Chaves MA,Leak MR,Poole J,Giles CM

更新日期：1988-01-01 00:00:00

abstract：:The presence of the glycoproteins haptoglobin and hemopexin in human plasma albumin (HPA) solutions were demonstrated to be responsible for the formation of polymers and aggregates during heat treatment for 10 h at 60 degrees C. Apart from haptoglobin and hemopexin three other contaminating proteins were identified as...

journal_title：Vox sanguinis

authors： Jensen LB,Dam J,Teisner B

更新日期：1994-01-01 00:00:00

abstract：:A selected group of women previously immunized in pregnancy by the Rh(D) antigen were boosted with 0.5 ml of Rh(D)-positive frozen recovered red cells from an accredited donor panel. The response was prompt and sustained and increased the anti-D content by almost 10-fold. In spite of the reduced rate of clinical immun...

journal_title：Vox sanguinis

authors： Gabra GS,Black M,Mitchell R

更新日期：1986-01-01 00:00:00

abstract：:The authors have studied the incidence of hepatitis associated antigen (HAA) and the homologous antibody in sera of patients with rheumatoid arthritis on the basis of (1) arthritis sometimes associated with viral hepatitis, (2) the possible infectious etiology of rheumatoid arthritis, and (3) observation on the possib...

journal_title：Vox sanguinis

authors： Marcolongo R,Debolini A

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:There are two presumed mechanisms for the pulmonary oedema in transfusion-related acute lung injury (TRALI). One is antibodies to leucocytes while the other is biologically active lipids. We evaluated the vascular injury due to the former. METHODS:The pulmonary vasculature was studied by light microscopy (L...

journal_title：Vox sanguinis

authors： Jensen HM,Galante JM,Kysar PE,Tolstikov VV,Reddy KJ,Holland PV

更新日期：2010-02-01 00:00:00

abstract：:Bacterial contamination of platelet concentrates poses a major post-transfusion infectious risk. This study was aimed at evaluating the efficacy of the BacTx(®) assay (Immunetics Inc.) for bacterial detection in leucocyte-reduced buffy coat platelet pools and for its sensitivity in detecting clinical isolates, includi...

journal_title：Vox sanguinis

authors： Ramirez-Arcos S,Kou Y,Perkins H

更新日期：2014-08-01 00:00:00

abstract：:Anti-HBc is the most sensitive indicator of current or recent hepatitis B virus infection, hence its detection is valuable in laboratory diagnosis of the infection. Dane particles isolated from the plasma of a single chronic carrier and his autologous IgG labeled with 125I were utilized in a solid-phase sandwich radio...

journal_title：Vox sanguinis

authors： Vyas GN,Roberts IM

更新日期：1977-12-01 00:00:00

abstract：:A large 81 member, four-generation black family with hereditary angioedema is reported with regards to its clinical course and the association with the histocompatibility system. No mortality was seen related directly to the disease. Assuming that this trait is autosomal dominant it appeared to have no linkage with th...

journal_title：Vox sanguinis

authors： Blumenthal MN,Dalmasso AP,Roitman B,Kelly J,Noreen H,Emmy L,Mendell NR,Yunis EJ

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In this EQA study a novel approach was used to assess the performance of blood centres and blood product manufacturers in detecting the possible contamination of plasma with HCV, HIV and HBV by NAT. MATERIALS AND METHODS:A panel of 12 samples, three negative and three positive for each virus,...

journal_title：Vox sanguinis

authors： Pisani G,Marino F,Cristiano K,Bisso GM,Mele C,Luciani F,Wirz M,Gentili G,External Quality Assessment Participants.

更新日期：2008-07-01 00:00:00

abstract：:The number of Lub antigen sites on the human erythrocyte membrane, as recognised by the murine monoclonal antibody BRIC-108, has been determined. The number of antibody molecules bound per cell on one example of cells of the phenotype Lu(a-b-) with recessive inheritance was an average of around 200 in replicate determ...

journal_title：Vox sanguinis

authors： Merry AH,Gardner B,Parsons SF,Anstee DJ

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Ross River virus (RRV) is an enveloped, RNA alphavirus in the same antigenic group as chikungunya virus. Australia records an annual average of 5000 laboratory-confirmed RRV infections. While RRV is currently geographically restricted to the Western Pacific, the capacity of arboviruses for rap...

journal_title：Vox sanguinis

authors： Seed CR,Hoad VC,Faddy HM,Kiely P,Keller AJ,Pink J

更新日期：2016-05-01 00:00:00

abstract：:Hepatitis B virus infectivity can be removed from human plasma used to prepare a gamma-globulin product by ion-exchange chromatography with commercially available resins. A pooled human plasma sample free of hepatitis markers was contaminated with 10,000 chimpanzee infectious doses of hepatitis B virus per milliliter ...

journal_title：Vox sanguinis

authors： Zolton RP,Padvelskis JV,Kaplan PM

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Plasma transfusions are a frequent treatment worldwide, but many studies have reported a wide variation in the indications to transfuse. Recently, an international paediatric study also showed wide variation in frequency in the use of plasma transfusions: 25% of the centres transfused plasma t...

journal_title：Vox sanguinis

authors： Karam O,Demaret P,Duhamel A,Shefler A,Spinella PC,Tucci M,Leteurtre S,Stanworth SJ,PlasmaTV investigators.

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The objectives of this study are to estimate the prevalence of iron deficiency (ID) among French whole-blood (WB) donors to identify factors associated with ID and to generate decision trees. STUDY DESIGN AND METHODS:A prospective National multicentre study was performed on WB donors from March 11, to April...

journal_title：Vox sanguinis

authors： Fillet AM,Martinaud C,Malard L,Le Cam S,Hejl C,Chenus F,Woimant G,Chueca M,Jacquot E,Besiers C,Morel P,Djoudi R,Garrabé E,Gross S

更新日期：2021-01-01 00:00:00

abstract：:When the blood group H sites of cord erythrocytes obtained from newborn infants of groups O, A, B and AB were labelled specifically by incubation of the whole cells with the A1 gene dependent alpha-N-acetylgalactosaminyl transferase in the presence of UDP-N-acetyl [14C]-galactosamine, the incorporation of radioactivit...

journal_title：Vox sanguinis

authors： Schenkel-Brunner H

更新日期：1980-06-01 00:00:00

abstract：:A family is reported in which the parents' mating is of the 'double back-cross' type with respect to the Sw, Lu and Se genes. The inheritance of these genes in the children shows, with reference to a possible linkage between Sw and the two other loci, four non-recombinants and three recombinants (or vice versa). The i...

journal_title：Vox sanguinis

authors： Metaxas MN,Metaxas-Buehler M

更新日期：1976-01-01 00:00:00

abstract：:The polymorphism of the second component of human complement was studied by means of isoelectric focusing in polyacrylamide gels with subsequent complement-dependent lysis of sensitized sheep erythrocytes in an agarose overlay containing C2-deficient or normal human serum. In a material of 289 unrelated individuals th...

journal_title：Vox sanguinis

authors： Dewald G,Rittner C

更新日期：1979-01-01 00:00:00

abstract：:Low-dose immune tolerance protocols use doses of factor VIII of less than 50 IU/kg/day to induce immune tolerance. Such protocols are chosen for a variety of reasons including cost, patient acceptability and ease of administration. Early published reports of low-dose protocols appeared in 1981, described small numbers...

journal_title：Vox sanguinis

authors： Sultan Y

更新日期：1999-01-01 00:00:00

abstract：:A pilot study for large-scale automated plasmapheresis using the Haemonetics Model 50 machine was undertaken in the Yorkshire Region of the United Kingdom to determine the viability of such a programme for national self-sufficiency in fresh plasma procurement for factor VIII concentrate production. The study was desig...

journal_title：Vox sanguinis

authors： Robinson AE,Penny AF,Smith J,Tovey DL

更新日期：1983-03-01 00:00:00

abstract：:A patient with Guillain-Barré syndrome was successfully treated by plasma exchange (without any other therapy), and the relationship between changes in his peripheral blood lymphocyte subpopulations and the clinical improvement induced by plasma-pheresis was studied. At the recovery, the most interesting findings were...

journal_title：Vox sanguinis

authors： Fiorini G,Bigi G,Paracchini ML,Marinig C,Gibelli A

更新日期：1982-01-01 00:00:00

abstract：:We developed a photodynamic method to inactivate viruses in human fresh plasma. Single plasma bags were illuminated with visible light in the presence of low doses of phenothiazine dyes like methylene blue or toluidine blue. By this treatment the infectivity of different enveloped viruses including the causative agent...

journal_title：Vox sanguinis

authors： Lambrecht B,Mohr H,Knüver-Hopf J,Schmitt H

更新日期：1991-01-01 00:00:00

abstract：:The formation of mono(ethylhexyl)phthalate (MEHP) from di(ethylhexyl)phthalate in human plasma stored in bags of polyvinylchloride has been studied. Substantial amounts were formed and in ten bags from 4 to 56microgram/ml were found. After 2 weeks at room temperature the concentration of MEHP had increased to values b...

journal_title：Vox sanguinis

authors： Vessman J,Rietz G

更新日期：1978-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Staphylococcus epidermidis is a predominant contaminant of platelet concentrates (PCs), outcompeting other skin flora bacteria such as Staphylococcus capitis. The accumulation-associated protein (Aap), encoded by the aap gene, is involved in formation of bacterial aggregates (biofilms) in S. e...

journal_title：Vox sanguinis

authors： Alabdullatif M,Ramirez-Arcos S

更新日期：2019-01-01 00:00:00

abstract：:Tissue oxygen delivery depends on red blood cell (RBC) content and RBC flow regulation in the microcirculation. The important role of the RBC in tissue oxygenation is clear from anaemia and the use of RBC transfusion which has saved many lives. Whether RBC transfusion actually restores tissue oxygenation is difficult ...

journal_title：Vox sanguinis

authors： Raat NJ,Ince C

更新日期：2007-07-01 00:00:00

abstract：:False-positive enzyme immunoassay (EIA) tests in blood donors receiving influenza vaccine were first reported in 1991. We conducted follow-up testing for 6 months of those donors with multiply reactive, but unconfirmed EIA (at least 2 positives in anti-HCV-1.0, anti-HIV-1, and anti-HTLV-I assays) with a history of rec...

journal_title：Vox sanguinis

authors： Arnold NL,Slade BA,Jones MM,Popovsky MA

更新日期：1994-01-01 00:00:00