Donor follow-up of influenza vaccine-related multiple viral enzyme immunoassay reactivity.

Abstract:

:False-positive enzyme immunoassay (EIA) tests in blood donors receiving influenza vaccine were first reported in 1991. We conducted follow-up testing for 6 months of those donors with multiply reactive, but unconfirmed EIA (at least 2 positives in anti-HCV-1.0, anti-HIV-1, and anti-HTLV-I assays) with a history of recent flu vaccine to determine the duration of false positivity. Of 133,000 donors tested, 16 met study criteria; all 16 were reactive for anti-HCV, 10 were reactive for anti-HIV-1, and 12 were reactive for anti-HTLV-I. Fifteen donors were available for follow-up testing (using the original screening and supplemental tests): 10 (67%) reverted to negative for the 3 tests and 5 remained false positive for various markers at last sampling (3-6 months after vaccination). The mean duration of false positivity for those reverting to negative EIA test status, was 4.2 months (range 2-7 months) indicating a transient phenomenon and supporting studies which suggest a role for IgM in the mechanism.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Arnold NL,Slade BA,Jones MM,Popovsky MA

doi

10.1111/j.1423-0410.1994.tb01658.x

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

191-4

issue

2

eissn

0042-9007

issn

1423-0410

journal_volume

67

pub_type

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