Abstract:
BACKGROUND AND OBJECTIVES:Weak ABO variants may escape tests using unlicensed sera. MATERIALS AND METHODS:Prior to transfusion, ABO grouping was performed using an automated system and in-house diluted sera, and manual and bedside test techniques. Genotyping and sequencing were performed using standard methods. RESULTS:Initially, the red blood cells (RBC) of the first-time blood donor were typed as B, but pretransfusion testing carried out using the bedside test indicated the presence of an additional A phenotype. Serological re-examination confirmed the bedside test results, and the allele in question was identified, by genotyping, as a new weak A variant (Aw11). CONCLUSIONS:The use of CE-marked and licensed antisera is recommended to avoid ABO mistyping.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Pruss A,Heymann GA,Braun J,Kiesewetter HH,Salama Adoi
10.1111/j.1423-0410.2006.00752.xsubject
Has Abstractpub_date
2006-04-01 00:00:00pages
195-7issue
3eissn
0042-9007issn
1423-0410pii
VOX752journal_volume
90pub_type
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