Rare and transient anti-D antibody response in D(-) liver transplant recipients transfused with D(+) red blood cells.

Abstract:

:A retrospective analysis was conducted on 20 D(-) liver transplant (LT) recipients transfused with D(+) RBCs perioperatively and screened for RBC antibodies between 2 and 6 months later. None developed anti-D detectable by the indirect antiglobulin test. Two patients produced weak anti-D that reacted only with papain-treated RBCs at 10 and 11 days without any sign of immune haemolysis. Antibodies became quickly undetectable. These data suggest an unusual pattern of alloimmunization in LT recipients with rapid, weak and transient antibody response and support the safety of transfusing D(+) RBCs in most of D(-) patients during LT surgery.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Burin des Roziers N,Ibanez C,Samuel D,Francoz C,Idri S,François A,Mortelecque R,Bierling P,Pirenne F

doi

10.1111/vox.12392

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

107-10

issue

1

eissn

0042-9007

issn

1423-0410

journal_volume

111

pub_type

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