Abstract:
:The effect of gamma irradiation on HIV and plasma coagulation factors F VIII:C, F VIII:vWF and FIX was studied. Donor plasma was harvested from single donations, frozen and irradiated in the frozen state at target doses from 0 to 40 kGy (0-4 mRad). HIV was inoculated into human plasma and irradiated in a similar manner. A range of other viruses, not suspended in plasma, were also irradiated to establish viral inactivation. An inactivation rate of 0.164 TCID50 dose/ml/kGy was demonstrated for HIV compared to rates of 0.00173, 0.00526 and 0.00286 log10 units/ml/kGy for F VIII:C,F VIII:vWF and FIX respectively. The use of gamma irradiation to inactivate infectious agents present in human plasma may eliminate the need for any post-production viral inactivation methods and provide a means of assuring the safety of as yet untreated products such as cryoprecipitate and fresh frozen plasma.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Kitchen AD,Mann GF,Harrison JF,Zuckerman AJdoi
10.1111/j.1423-0410.1989.tb02033.xsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
223-9issue
4eissn
0042-9007issn
1423-0410journal_volume
56pub_type
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