Abstract:
:Immunoblotting with human anti-Sc1 and anti-Sc2 locates the Sc1 and Sc2 antigens to an erythrocyte membrane glycoprotein of apparent Mr 60,000. The antigens are destroyed by pronase, and require intact disulphide bonds for expression. A proportion of the molecules carrying the Sc1 and Sc2 antigens are associated with red cell cytoskeleton preparations. Treatment of intact cells with an Endo F preparation resulted in the loss of the Sc2 antigen but not the Sc1 antigen, suggesting that the Sc2 antigen is dependent on the presence of one or more complex N-glycans for its expression.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Spring FA,Herron R,Rowe Gdoi
10.1111/j.1423-0410.1990.tb02074.xsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
122-5issue
2eissn
0042-9007issn
1423-0410journal_volume
58pub_type
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