Abstract:
:We studied 684 sera obtained from 20 hemophilia patients with AIDS/AIDS-related complex (ARC), 89 asymptomatic HIV+, 76 HIV- hemophilia patients and 151 healthy controls for antibodies against recombinant CD4 (rCD4). Twenty-two percent of AIDS/ARC patients, 10% of asymptomatic HIV+ patients, 17% of HIV-patients, and 1% of healthy controls had anti-rCD4 antibodies. Purified anti-rCD4 antibodies did not react with human CD4+ lymphocytes. This may explain why formation of anti-rCD4 antibodies correlated neither with the occurrence of autoantibodies against CD4+ lymphocytes nor with a decrease in CD4+ cell counts. Antibodies that were eluted from CD4+ lymphocytes after sequential adsorption and elution with separated CD8+ and CD4+ cells reacted with CD4+ lymphocytes of only some healthy individuals, suggesting diversity of CD4 expression.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Daniel V,Weimer R,Zettlmeissl G,Langner K,Zimmermann R,Opelz Gdoi
10.1111/j.1423-0410.1992.tb01165.xsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
39-44issue
1eissn
0042-9007issn
1423-0410journal_volume
62pub_type
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