Abstract:
:Emerging data in animal models and humans suggest that pathogen-associated and damage-associated molecular patterns variably impact RBC alloantibody formation. In this study, we tested the hypothesis that vaccinations may enhance immune responses to transfused RBCs. The Pneumovax23 vaccine decreased the magnitude of anti-KEL alloimmunization in a murine model, whereas the hepB vaccine did not impact the response; RBC transfusion did not alter immune responses to either vaccine. These data highlight the complexities of the intersection of innate and adaptive immunity and suggest that future studies investigating the pathways through which inflammation impacts alloimmunization are warranted.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Natarajan P,Santhanakrishnan M,Tormey CA,Hendrickson JEdoi
10.1111/vox.12541subject
Has Abstractpub_date
2017-08-01 00:00:00pages
598-600issue
6eissn
0042-9007issn
1423-0410journal_volume
112pub_type
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