The impact of vaccination on RBC alloimmunization in a murine model.

Abstract:

:Emerging data in animal models and humans suggest that pathogen-associated and damage-associated molecular patterns variably impact RBC alloantibody formation. In this study, we tested the hypothesis that vaccinations may enhance immune responses to transfused RBCs. The Pneumovax23 vaccine decreased the magnitude of anti-KEL alloimmunization in a murine model, whereas the hepB vaccine did not impact the response; RBC transfusion did not alter immune responses to either vaccine. These data highlight the complexities of the intersection of innate and adaptive immunity and suggest that future studies investigating the pathways through which inflammation impacts alloimmunization are warranted.

journal_name

Vox Sang

journal_title

Vox sanguinis

authors

Natarajan P,Santhanakrishnan M,Tormey CA,Hendrickson JE

doi

10.1111/vox.12541

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

598-600

issue

6

eissn

0042-9007

issn

1423-0410

journal_volume

112

pub_type

杂志文章
  • Platelet-rich plasma and platelet gel preparation using Plateltex.

    abstract:BACKGROUND:The platelet gel is made by embedding concentrate platelets within a semisolid (gel) network of polymerized fibrin. It is believed that this blood component will be used more and more in the treatment of several clinical conditions and as an adjunctive material in tissue engineering. Several systems are avai...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2007.01027.x

    authors: Mazzucco L,Balbo V,Cattana E,Borzini P

    更新日期:2008-04-01 00:00:00

  • Factors associated with fainting: before, during and after whole blood donation.

    abstract::BACKGROUND  Whole blood (WB) donation encompasses several periods during which some donors faint. Identification of factors associated with fainting during each period should guide intervention strategies. Reducing faint reactions may reduce donor injuries and disability. METHODS  Blood donation was divided into three...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2011.01494.x

    authors: Bravo M,Kamel H,Custer B,Tomasulo P

    更新日期:2011-11-01 00:00:00

  • Autoantibodies in HIV-infected hemophilia patients against different epitopes on CD4+ lymphocytes and recombinant CD4.

    abstract::We studied 684 sera obtained from 20 hemophilia patients with AIDS/AIDS-related complex (ARC), 89 asymptomatic HIV+, 76 HIV- hemophilia patients and 151 healthy controls for antibodies against recombinant CD4 (rCD4). Twenty-two percent of AIDS/ARC patients, 10% of asymptomatic HIV+ patients, 17% of HIV-patients, and 1...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1992.tb01165.x

    authors: Daniel V,Weimer R,Zettlmeissl G,Langner K,Zimmermann R,Opelz G

    更新日期:1992-01-01 00:00:00

  • Evaluation of two different protocols for peripheral blood stem cell collection with the Fresenius AS 104 blood cell separator.

    abstract:OBJECTIVES:Reconstitution of hematopoiesis by means of peripheral blood stem cells is a valid alternative to autologous bone marrow transplantation. The aim of this investigation was to increase the efficiency of collection of circulating blood progenitor cells and to obtain a purer product for transplant. METHODS:We ...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1423-0410.1997.7340230.x

    authors: Menichella G,Lai M,Pierelli L,Vittori M,Serafini R,Ciarli M,Foddai ML,Salerno G,Sica S,Scambia G,Leone G,Bizzi B

    更新日期:1997-01-01 00:00:00

  • Complement and biocompatibility.

    abstract::Blood contact with foreign surfaces induces a certain degree of activation of the defence systems including complement. Recent data using complement specific inhibitors have shown that complement is not only associated with, but in fact contributes to the whole body inflammatory reaction seen as a complication of card...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1998.tb05435.x

    authors: Mollnes TE

    更新日期:1998-01-01 00:00:00

  • Progression to AIDS in relation to clinical factors and clotting product consumption. A 14-year follow-up of a cohort of 52 Dutch HIV-1-infected haemophilic patients.

    abstract:OBJECTIVE:In order to describe the progression of HIV disease in a cohort of Dutch HIV-1-infected patients with haemophilia and to study the influence of clinical and clotting factors, we performed a 15-year longitudinal clinical and laboratory study. METHODS:The progression to AIDS in relation to type of haemophilia,...

    journal_title:Vox sanguinis

    pub_type: 临床试验,杂志文章

    doi:

    authors: Roosendaal G,van der Schouw Y,Mauser-Bunschoten E,Borleffs J,van den Berg H

    更新日期:1998-01-01 00:00:00

  • TRALI is due to pulmonary venule damage from leucocytes with cholesterol crystal formation.

    abstract:BACKGROUND:There are two presumed mechanisms for the pulmonary oedema in transfusion-related acute lung injury (TRALI). One is antibodies to leucocytes while the other is biologically active lipids. We evaluated the vascular injury due to the former. METHODS:The pulmonary vasculature was studied by light microscopy (L...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2009.01235.x

    authors: Jensen HM,Galante JM,Kysar PE,Tolstikov VV,Reddy KJ,Holland PV

    更新日期:2010-02-01 00:00:00

  • Rh haplotypes that make e but not hrB usually make VS.

    abstract:BACKGROUND AND OBJECTIVES:The Rh phenotypes hrB- and VS+ are both rare in Whites but more common in Blacks. The high-incidence antigen hrB is present on most red cells that are e+. The presence of VS on red cells is associated with an aberrant expression of e, often called eS. MATERIALS AND METHODS:Using conventional ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.1997.00041.x

    authors: Reid ME,Storry JR,Issitt PD,Combs MR,Beal CL,Mallory DA,Blancher A

    更新日期:1997-01-01 00:00:00

  • Hemovigilance in the United States of America.

    abstract::Although hemovigilance is not a word used commonly in the United States, the concept of monitoring morbidity associated with blood transfusion is accepted widely. Currently, quality management focuses on error avoidance rather than error detection in both the "manufacturing" and "clinical" aspects of blood banking. "M...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1998.tb05455.x

    authors: Menitove JE

    更新日期:1998-01-01 00:00:00

  • Fluid motion and shear forces in platelet storage bags with different modes of agitation.

    abstract::This study describes a new method for comparison of fluid motion and associated shear forces with various modes of platelet agitation. Fluid motion generated by flatbed, tumbler-type and circular platelet agitators was investigated. Trajectory tracings of polyethylene beads suspended inside platelet storage bags were ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12409

    authors: Torres R,Tormey CA,Stack G

    更新日期:2016-08-01 00:00:00

  • HLA-DR: serology versus restriction fragment length polymorphism.

    abstract::The results of the serological typing and the patterns of restriction fragment length polymorphisms for the detection of HLA-DR gene products are compared. The data shown demonstrate that the use of DNA typing gives a clearer definition of the HLA-DR antigens and that the HLA-DR polymorphism is greater than detected b...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1991.tb00928.x

    authors: Nagy M,Mayr WR,Menzel GR

    更新日期:1991-01-01 00:00:00

  • Delayed hemolytic transfusion reaction associated with Rh antibody anti-f: first reported case.

    abstract::A delayed hemolytic transfusion reaction (DHTR) occurring in a 30-year-old Caucasian man is described. His blood groups were B, CDe/cDE (R1R2, f-) K-, S-s+, Fy (a + b-), and Jk (a + b +). Eight days after receiving two units of packed red blood cells, his urine was strongly positive for hemoglobin; serum-free hemoglob...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1985.tb00808.x

    authors: O'Reilly RA,Lombard CM,Azzi RL

    更新日期:1985-01-01 00:00:00

  • The effects of leg crossing and applied tension on blood donor return.

    abstract:BACKGROUND AND OBJECTIVES:Repeated isometric muscle tension (applied tension) during blood donation reduces vasovagal symptoms in many donors. Experiencing vasovagal symptoms has been found to reduce blood donor return. However, does practicing applied tension improve blood donor return? Follow-up results from a random...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/vox.12055

    authors: Ditto B,Gilchrist PT,Holly CD,Dubuc S,Delage G,France CR

    更新日期:2013-11-01 00:00:00

  • An analysis of autologous blood donor motivational factors.

    abstract::Little is known about the patient's reasons for participating in an autologous blood (AUB) collection program. We surveyed 110 AUB donors in our hospital-based collection program. Although fear of infection from an allogeneic blood transfusion was cited by 20% of AUB donors, 68.2% indicated that their physician's reco...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1995.tb01679.x

    authors: Domen RE,Ribicki LA,Hoeltge GA

    更新日期:1995-01-01 00:00:00

  • Expression of genetic markers of erythrocyte immunoglobulin G autoantibodies in autoimmune hemolytic anemia.

    abstract::The Gm allotype constitution of the autoantibody molecules and the serum Gm phenotypes were determined in 19 patients with autiommune hemolytic anemia of IgG type. The results showed that the known heterogeneity of the antierythrocyte autoantibodies in this disease concerns not only the immunoglobulin class and the is...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1976.tb02208.x

    authors: Le Petit JC,Rivat L,François N,Ropartz C,Brizard CP

    更新日期:1976-01-01 00:00:00

  • Evaluation of two-step haemoglobin screening with HemoCue for blood donor qualification in mobile collection sites.

    abstract:BACKGROUND AND OBJECTIVES:Inaccuracy of fingerstick haemoglobin compromises donor's health and losses blood donations. We evaluated the benefit of double haemoglobin screening with HemoCue. STUDY DESIGN AND METHODS:Blood donors underwent fingerstick screening by HemoCue and were driven for donation if capillary haemog...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12165

    authors: Gómez-Simón A,Plaza EM,Torregrosa JM,Ferrer-Marín F,Sánchez-Guiu I,Vicente V,Lozano ML,Rivera J

    更新日期:2014-11-01 00:00:00

  • Estimation of the number of binding sites for a murine monoclonal anti-Lub on human erythrocytes.

    abstract::The number of Lub antigen sites on the human erythrocyte membrane, as recognised by the murine monoclonal antibody BRIC-108, has been determined. The number of antibody molecules bound per cell on one example of cells of the phenotype Lu(a-b-) with recessive inheritance was an average of around 200 in replicate determ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1987.tb04915.x

    authors: Merry AH,Gardner B,Parsons SF,Anstee DJ

    更新日期:1987-01-01 00:00:00

  • Development of a mitochondrial DNA real-time polymerase chain reaction assay for quality control of pathogen reduction with riboflavin and ultraviolet light.

    abstract:BACKGROUND AND OBJECTIVES:Transfusion is associated with a risk of infection and alloimmunization. Pathogen reduction using riboflavin and UV light (Mirasol treatment) inactivates pathogens and leucocytes. With increasing adoption of the technology in clinical use, regulatory agencies have recommended the introduction ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12173

    authors: Bakkour S,Chafets DM,Wen L,van der Meer PF,Mundt JM,Marschner S,Goodrich RP,Busch MP,Lee TH

    更新日期:2014-11-01 00:00:00

  • Increase in glycocalicin levels in platelet concentrates stored in plasma or synthetic medium for 8 days: comparison with other platelet activation markers.

    abstract:BACKGROUND AND OBJECTIVES:Glycocalicin (GC) is a proteolytic fragment of GpIb and can conveniently be measured in supernatants of platelet concentrates (PCs) by means of a sandwich ELISA. Because of the convenience of the assay and easy sample storage, we tested its suitability as a sensitive platelet activation parame...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1159/000031201

    authors: Kostelijk EH,Folman CC,Gouwerok CW,Kramer CM,Verhoeven AJ,de Korte D

    更新日期:2000-01-01 00:00:00

  • Prothrombin complex concentrates for clinical use.

    abstract::Prothrombin complex concentrates prepared for clinical use are reviewed with emphasis on frequently observed adverse reactions such as viral hepatitis and thromboembolic complications. Preparation procedures and quality control are described briefly, and the use of these concentrates in the treatment of hemophilia A p...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1981.tb01048.x

    authors: Chandra S,Brummelhuis HG

    更新日期:1981-11-01 00:00:00

  • Organizational models for health actions in the field of blood and blood products in Brazilian and Spanish regional contexts.

    abstract:BACKGROUND AND OBJECTIVES:This article aims to characterize some elements that define the organizational models of healthcare actions in the field of blood and blood products. MATERIALS AND METHODS:This exploratory and qualitative study was carried out based on a documentary survey complemented by interviews with key ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12665

    authors: Souza MKB

    更新日期:2018-05-21 00:00:00

  • Supernatants of stored polymorphonuclear neutrophils exhibit growth-promoting activity in several cell lines: perforin expression in polymorphonuclear neutrophils and its role in down-regulation of growth-promoting activity.

    abstract:BACKGROUND AND OBJECTIVES:Polymorphonuclear neutrophils (PMNs) play important roles in the host immune defence. This study was performed to identify roles of PMNs other than those already known. MATERIALS AND METHODS:PMNs were separated from the peripheral blood of healthy individuals and stored in vitro for 24 h in t...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1046/j.1423-0410.2002.00156.x

    authors: Nishimura M,Mitsunaga S,Juji T

    更新日期:2002-04-01 00:00:00

  • Reticulocyte count in red-blood-cell units stored in AS-1.

    abstract:BACKGROUND AND OBJECTIVES:Previous data that showed maintenance of reticulocyte percentage in whole blood stored in CPDA-1 have led to the assumption that reticulocyte maturation becomes arrested during refrigerated storage. However, reticulocyte behaviour in red-blood-cell units stored in additive solutions has not ye...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/vox.12011

    authors: Urbina A,Palomino F

    更新日期:2013-05-01 00:00:00

  • A 'new' allele, Kpc, at the Kell complex locus.

    abstract::Four Kp(a-b-) Japanese sisters, the product of a consanguineous mating, have otherwise normal Kell antigens. Kpc, a 'new' allele of Kpa and Kpb is the most probable background. ...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1979.tb04395.x

    authors: Yamaguchi H,Okubo Y,Seno T,Matsushita K,Daniels GL

    更新日期:1979-01-01 00:00:00

  • Population study of heterophile antibodies.

    abstract::Sera from 2,829 participants in a population health survey were tested for the presence of a heterophilic antibody, detectable by immunofluorescence. The antibody was found in 9.8% of the sera from women and in 12.4% of the sera from men. The age-specific prevalence of the antibody was relatively constant in women but...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1980.tb02973.x

    authors: Hawkins BR,Saueracker GC,Dawkins RL,Davey MG,O'Connor KJ

    更新日期:1980-12-01 00:00:00

  • Rapid thawing of fresh-frozen plasma with radio wave-based thawing technology and effects on coagulation factors during prolonged storage at 4 degrees C.

    abstract:BACKGROUND AND OBJECTIVES:With traditional techniques the thawing time for fresh-frozen plasma (FFP) is about 20-30 min. A new technology using radio waves, radio wave thawing device (RTD), was applied for thawing FFP. With this technology the thawing time can substantially be reduced. The new technique was compared to...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.2009.01175.x

    authors: Boström F,Ekemar L,Olsson D,Egberg N,Lundahl J

    更新日期:2009-07-01 00:00:00

  • Current problems and results in testing microaggregate filters.

    abstract::Most in vitro studies on microaggregate filters focus on the mechanical retention of microparticles. Data are based on bulk techniques such as differential dry weight and screen filtration pressure measurements or single-particle counting using resistance measurement (Coulter principle). Errors in measurements may res...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1979.tb02310.x

    authors: Eisert WG,Eckert G

    更新日期:1979-01-01 00:00:00

  • Perioperative red cell transfusion: evidence, guidelines and practice.

    abstract::Although we still do not know enough about the influence of anaemia and transfusion on outcomes for the surgical patient, it is possible to develop a general consensus about many aspects of management. A quality programme to improve consistency of practice in these consensus areas is feasible. (Table 6) This should be...

    journal_title:Vox sanguinis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1423-0410.1998.tb05393.x

    authors: McClelland B

    更新日期:1998-01-01 00:00:00

  • Peroxidative events in stored platelet concentrates.

    abstract::Changes in metabolic and functional activity of platelets stored as platelet concentrates in plastic bags highly permeable to gases were investigated. The following parameters were measured daily: pH, pO2, pCO2, HCO3, glucose, lactic acid, lactic dehydrogenase, cellular ATP and platelet aggregation induced by differen...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1989.tb03043.x

    authors: Fagiolo E,Lippa S,Mores N,Oradei A,Aureli V

    更新日期:1989-01-01 00:00:00

  • A chromatographic procedure for the purification of human plasma albumin.

    abstract::Albumin is obtainable from human blood plasma by an ion exchange chromatographic procedure in a yield of about 95% and a purity well above Pharmacopoeia requirements. Cryosupernatant, factor IX depleted plasma is precipitated with 12 and 25% w/v polyethylene glycol 4000. The second precipitate is dissolved to 8% w/v p...

    journal_title:Vox sanguinis

    pub_type: 杂志文章

    doi:10.1111/j.1423-0410.1977.tb02240.x

    authors: Curling JM,Berglöf J,Lindquist LO,Eriksson S

    更新日期:1977-08-01 00:00:00